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Had better understanding of the brain than anyone else up to the 19th century; discovered via surgical notes that prescribed treatments |
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1st known Egyptian healer |
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injury to one side of head causes pressure buildup on opposite side & skull, reluting in symptoms on same side as injury |
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Aristotle/Greek's perspective |
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"it's what's in your heart, not brain"; brain was seen as cooling mechanism for hot blood form heart |
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Medieval theories: hydraulic theory |
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brain is composed of ventricles filled with fluid |
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knew that cortex serves functions of memory & will but had no idea about localization of function. He was ignored because he was too advanced for his time. |
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phrenologist who believed the cortex was a set of organs, each with a different function, that gray matter is functioning neural tissue connected to white matter, and he gave a clear description of the corpus collosum. He knew the cortex was folded up to conserve space. |
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considered father of physiological psych; argued that laguage ability was localized to a specific region of brain; figured out the connection of loss of speech with left frontal lobe damage |
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Briefly describe two of the true discoveries made by Franz Joseph Gall |
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1. He talked about cortical regions of the brain, describing the corpus collosum fairly accurately- connective band between the hemispheres of the brain
2. Knew that cortex was folded up to conserve space |
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the skilled movements (playing sports, other complex tasks) |
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spinal cord is involved in: |
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relaying sensory to the brain, taking motor sensory commands from the brian to the muscles, and reflexes |
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the brain stem is composed of both the ___ and ____ |
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midbrain (mesencephalon) AND hindbrain |
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Nerves of the sympathetic nervous system: |
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1. cranial
2. cervical
3. Thoracic
4. Lumbar
5. Sacral |
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middle of the brain vs. towards the outside of the brain |
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major infolding of the cortex |
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sulcus is a much more deep infolding of the cortex than a fissure |
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outpouchings of the brain (opposite of fissures/sulci) |
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carrying signal from neuron to neuron |
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cell assembly level of neural aggregation; contains 2-3 neurons a piece |
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cell system stimulus loop that happens at cell assemblies level; Hebb thought this was the basis of a very brief memory; stops when one cell becomes refractory |
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neural aggregation: Minicolumns |
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level of neural aggregation containing about 100 neurons each; visible in stained brain slices; most often studied in primary visual cortex; called visual columns; can be thought of a feature detectors |
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neural aggregation: functional columns |
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collection of minicolumns; about 8000 neurons total (about 80 minicolumns in each functional column); |
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neural aggregation: cytoarchitectonic areas |
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based on layers of cells and how they're connected, there can be multiple patterns and multiple layers per pattern. people who study cytoarchitectonic areas look at the changes in shape & color and label boundaries of brain based on these changes. |
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cytoarchitectonic anatomist; produced a cytoarchitectonic areas map and identified about 50 areas per hemisphere; Broadmann's map is missing about 300 total areas |
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A representation of the body in the cortex, across a band of cortex tissue in front of central sulcus and across precentral gyrus. Little strips of cortex that corespond to parts on the body and cause stimulation in those parts. Important because it's all in one cytoarchitectonic area. Means "little man". |
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neural aggregations: lobules |
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different lobules involved in different functions; a small segment or lobe, especially one of the smaller divisions making up a lobe. |
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orbital frontal cortex location |
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damage to orbital frontal cortex causes |
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pseudopsychopathic behaviors - social inappropriateness |
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neural aggregation: lobes |
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4 ceberal lobes:
- Frontal lobe—conscious thought; damage can result in mood changes, social differences, etc. The frontal lobes are the most uniquely human of all the brain structures.
- Parietal lobe—plays important roles in integrating sensory information from various senses, and in the manipulation of objects; portions of the parietal lobe are involved with visuospatial processing
- Occipital lobe—sense of sight; lesions can produce hallucinations
- Temporal lobe—senses of smell and sound, as well as processing of complex stimuli like faces and scenary
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neural aggregation: cerebal halves |
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right is spatial, left is verbal/language; |
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basic logic used in PET scans and FMRI; the difference in brain activity in the scans can be cimputed & represented as a color-coded "difference images" that shows the areas of the brain that were most active during the experimental condition.
Difference images from several subjects can be added together, averaged, and used to make a "mean difference image" that shows the most active brain areas for all subjects in an experiment. Subtracts out visual activity not related to experiment. |
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problems with subtractive method |
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1. Averaging criticisms: activation varies throughout the brain; averaging them together can wash out your results
2. Appropriate control criticism: your choice of the control situation will affect how you read your results. Use multiple controls to fix this.
3. Home Simpson criticism: you may be thinking of other things that could cause activation other than what you're being tasked with. |
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activation in the image no necessary to the task (used in Homer Simspon criticism of subtractive imaging) |
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winnowing methods: conjunction analysis |
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use several tasks that are all believed to use the same mental process; when viewing difference images, the areas of activation they'll have in common are extremely likely to all be involved in this same task |
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winnowing methods: correlation to performance |
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if you have an area of the brain that is specifc to a task, when the subject is performing that task extremely well there should be a lot of activity in that area, and low activity when low performance occurs |
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cutaneous system, skin: epidermis |
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the outer layer made up of dead skin cells |
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cutaneous system, skin: dermis |
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below the epidermis and contains mechanoreceptors that respond to stimuli such as pressure, stretching, and vibration |
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Electroencephalography (EEG) , then separated into different frequency bands |
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- projects contralaterally (to opposite side of brain)
- has large-diameter neurons
- carried precision information about form, position, timing |
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- projects bilaterally (to both sides of brain)
- has small-diameter neurons
- carries less precise versions of form, position, timing
- also carries information about temperature and pain |
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left occipital lobe is active in |
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critical to reading visual word form |
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left angular gyrus / area 39 active in |
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connection from print to sound. |
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Neurons usually have how many synapses? |
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5,000-10,000 synapses a piece |
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small gap between synaptic knob and dendrite of neighboring cell. First named by Sherrington in 1897 |
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a brain0imaging technique in which a specialized x-ray image of the head is taken shortly after the cerbral blood vessels have been filled with a radiopaque dye via catheter |
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Computerized Axial Tomography (CAT or CT) |
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A noninvasive technique for examining brain structure in humans through computer analysis of x-ray absorption at several positions around the head |
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Magnetic Resonance Imaging (MRI) |
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non-invasive technique that uses magnetic energy to generate image that reveal some structural details in the living brain |
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Positron Emissions Tomography (PET) |
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scan technique for examining brain function by combining tomography with injections of radioactive substances used by the brain; PET maps radioactive tracers to produce images of brain activity.
Objective is to obtian images of brain's activity rather than structure |
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Functional Magentic Resonance Imaging (fMRI) |
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MRI that detects changes in blood flow and therefor identifies regions of the brainthat are particulary active during a given task; FMRIs use local changes in metabolism to identify active brain regions |
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uses near-infrared light to pass though into cortex and view the activity of cortical regions |
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Transcranial Magnetic Stimulation (TMS) |
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Localized, noninvasive stimulation of cortical neurons through the application of strong magnetic fields |
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Magnetoencephalography (MEG) |
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A passive and noninvasive functional brain-imaging technique that measures the tiny magnetis fields produced by active neurons, in order to identify regions of the brain that are particularly active during a given task.
Excellent for studying rapidly shifting patterns of brain activity in cortical circuits, especially when paired with MRI. |
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Information flows within a neuron by |
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Information flows between neurons by |
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The action potential is caused by this chemical state |
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the movement of sodium (NA+) into the cell through channels in the membrane |
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Event-related Potential (ERP) |
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measure changes resulting from discrete stimuli, such as light flashes or clicks. many ERPs are averaged to find a reliable estimate of stimulus-elicited brain activity. |
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the rules by which action potentials in a sensory system reflect a physical stimulus |
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the maximal rate of firing for a single nerve cell |
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about 1200 actoin potential per second, and most sensory fibers don't fire more than a few hundred action potentials per second |
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Sensory systems emphasize ______ because it is more likely to be significant for survival |
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sensory adaptation prevents |
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the nervous system from becoming overwhelmed by stimuli |
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the brain regions at the top of the brainstem that trade information with the cortex |
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Primary Somatosensory (S1) |
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The gyrus just posterior to the central sulcus where sensory receptors on the body surface are mapped. Primary cortex for receiving touch and pain information, in the parietal lobe. |
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delivers most touch stimuli via the dorsal columns of the spinal white matter to the brain; carries somatosensory info from the skin to the brain |
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Merzenich and Kenkins used a monkey and finger amputation to find that |
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cortical maps can change with experience |
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3 Ways pain helps us (Dennis & Melzack) |
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- Short-lasting pain causes us to withdraw from the source, often reflexively, thus preventing further damage
- Long-lasting pain promoted behaviors, such as sleep, inactivity, grooming, feeding, and drinking, that promote recuperation
- The expression of pain serves as a social signal in other animal species
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The human ear is specially shaped to capture this frequency because is has to do with this function |
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2000-5000 Hz because it's a frequency range important for speech perception |
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3 small bones (incus, malleus, and stapes) that transmit sounds across the middle ear, form the tympanic membrane to the oval window
malleus = hammer
incus = anvil
stapes = stirrup |
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The cohclea converts ___ to ____ |
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vibrational energy into waves of fluid |
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2 main theories how we discriminate pitch: |
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- Place Theory: argues that pitch is encoded in the physical location of the activated receptors along the basilar membrane
- Volley Theory: proposes that the frequency of auditory stimuli is directly encoded into the firing pattern of auditory neurons
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An anterior projection of the brain that ends in the upper nasal passages and, through smal openings in the skull, provides receptors for smell |
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Hecaen: elementary hallucinations |
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indistinct noises (hums, murmurs, etc)
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annoying
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usually perceived as not real
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