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Term 1, Histology Lecture 1
Epithelium and Glands
58
Medical
Graduate
09/13/2009

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Term
Six characteristics of epithelium
Definition
1. It lines the internal body surface
and covers the external
2. Can consist of one layer (simple) or
more (startified) arranged into
sheets
3. is contiguous, having little
intercellular space between cells
4. is avascular
5. composed of polarized epithelial
cells, specialized to perform a
variety of vectoral fxns
6. is separated from the underlying
connective tissue by a filamentous
layer of basement membrane
Term
Epithelia is characterized by these two aspects
Definition
It is classified by:
- the number of cell layers and
- the shape of the superficial cell layer
Term
The nine types of epithelium
Definition
1. Simple squamous
2. Simple cuboidal
3. Simple columnar
4. Stratified squamous non-keratinized
5. Stratified squamous keratinized
6. Stratified cuboidal
7. Stratified columnar
8. Pseudostratified
9. Transitional
Term
Simple squamous epithelium consists of these types of cells
Definition
This epithelium has a single layer of flattened cells
Term
Simple squamous epithelium can often be found at these locations
Definition
It is the endothelium of blood vessels and lines the pleural, peritoneal and other serous cavities
Term
General locations of simple cuboidal epithelium
Definition
is found lining small ducts and tubules that have secretory, excretory or absorptive function
Term
General locations of simple columnar epithelium
Definition
It is found lining the absorptive surfaces and secretory surfaces
Term
An important characteristic of
Stratified squamous non-keratinized epithelium
Definition
Its superficial layer has flat nucleated cells
Term
An important characteristic of
Stratified squamous keratinized epithelium
Definition
Its most superficial layer has lost its nuclei and is filled with keratin
Term
Stratified squamous non-keratinized epithelium is usually found here
Definition
lining most internal body surfaces such as the mouth, esophagous and vagina
Term
Stratified squamous keratinized epithelium is usually found here
Definition
the skin
Term
Stratified cuboidal epithelium is usually found here
Definition
It lines the ducts of sweat glands
Term
Typical locations of Stratified columnar epithelium
Definition
Can be found i large excretory ducts of some glands and in the urethra
Term
Important characteristic of pseudostratified epithelium
Definition
Nuclei of cells are not all in the same plane though every cell is resting on a basement membrane. Not all cells will extend up to the lumen
Term
Morphology of transitional epithelium
Definition
A stratified epithelium whose superficial cells, when relaxed, are dome shaped and bule into the lumen
Term
Between the lateral surface of epithelial cells are these specializations
Definition
Junctional complexes
Term
Junctional complexes are seen as these under a light microscope
Definition
They are seen as a terminal bar
Term
The 3 components of junction complexes
Definition
Zonula adherens, ZOnula occludens and Macula Adherens
Term
Another term for Zonula occludens
Definition
Tight junctions are another name
Term
Function of Zonula occludens
Definition
They serve to prevent the entrance/exit of substances into the intercellular space from the lumen
Term
This determines the leakiness of zonula occludens
Definition
The complexity and number o strands comprising the junction from the apical to basal direction
Term
Zonula occludens form this
Definition
a zone around the entire apical perimeter of adjacent plasma membranes
Term
Another term for Zonula Adherens
Definition
AN intermediate junction or Belt desmosome
Term
Location of Zonular adherens
Definition
They extend around the perimeter of the epithelial cell, just under the zonula occludens
Term
Zonula adherens allow separation between cells at this distance
Definition
They allow separation of 10-20nm between of cells
Term
Zonula adherens have these structures on their cytoplasmic surface
Definition
They have actin filaments extending into the termnal web
Term
Structure and location of Macula adherens
Definition
These are focal and disk-shaped and located between the lateral sides of epithelial cells
Term
Another term for Macula adherens
Definition
They are also called desmosomes
Term
Macula adherens allow seperation of epithelial cells at this distance
Definition
These allow separation of epithelial cells at 15-30nm.
Term
Other terms for Gap Junction
Definition
They are also called a Communicating Junction or a Nexus
Term
Gap Junctions contain these subunits and with this type of arrangement
Definition
Opposing plasma membranes contain subunits of COnnexin arranged radially around a central canal
Term
Role of gap junction
Definition
It permits the passage of small molecules and ions between cells
Term
Function of Lateral interdigitations
Definition
They are fingerlike projections that interlock adjacent epithelial cells
Term
Two characteristics of the basal lamina
Definition
It is acellular and is produced by the epithelium resting on it
Term
The composition of Basal Lamina
Definition
It is comprised of Type IV collagen, laminin and proteoglycan
Term
The two zones of the basal lamina
Definition
The lamina rare/lucida and the lamina densa
Term
The two components of the basement membrane
Definition
Basal lamina and reticular lamina
Term
Function of the hemidesmosome
Definition
It attaches cells to the underlying basal lamina
Term
Purpose of Microvilli
Definition
It extends into the lumen and increases the absorptive surface area of cells
Term
Microvilli are characterized by these molecules
Definition
They have a glycocalyx coat on their exterior surface
Term
Microvilli contain these types of filaments
Definition
They contain 30 longitudinally arranged actin filaments extending into the terminal web of the apical cytoplasm
Term
Def of Cilia
Definition
Actively motile specializations that transport substances along their surface
Term
Cilia contain this functional unit
Definition
The axoneme
Term
COmponents of teh axoneme
Definition
It contains 9 pairs of doublet microtubules uniformly spaced around a single pair of microtubules
Term
The arms of cilia contain this molecule
Definition
They contain a dynein ATPase
Term
This is at the base of each cilium
Definition
A basal body is found here
Term
The structure of a basal body
Definition
They have 9 triplet microtubules radially arranged
Term
Three major types of glandular epithelium
Definition
Two major types are exocrine, endocrine and paracrine
Term
The origin of glandular epithelium
Definition
They originate from lining epithelium and penetrate the connective tissue to form secretory units
Term
Two fxnal characteristics of endocrine glandular epithelium
Definition
They lack ducts and release their contents into the bloodstream
Term
Two fxnal characteristics of endocrine glandular epithelium
Definition
They lack ducts and release their contents into the bloodstream
Term
Two subcategories of multicellular exocrine glands
Definition
Simple and Compound glands
Term
The shape classifications of multicellular exocrine glands
Definition
- Acinar (sac-like)
- Alveolar (flask-like)
- Tubule (either straight, coiled or branched)
Term
4 ways of describing the location of ducts within glands
Definition
- interlobar (btwn lobes)
- intralobar (w/in lobes)
- interlobular (btwn lobules)
- intralobular (w/in lobules)
Term
3 types of secretions by exocrine glands
Definition
mucous, serous and mixed
Term
serous secretions are describes as this
Definition
these secretions are water and rich in enzymes
Term
Three methods of secretions by exocrine glands
Definition
Mericrine (exocytosis), apocrine and holocrine
Term
Three types of apical surface specializations in epithelium
Definition
Microvilli, stereo cilia and cilia
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