Term
|
Definition
INH 300 qd x9m with 10-50mg Vit. B6
INH 900 BIW x9m by DOT with Vit. B6
RIF 600 QD x4m when INH resistance or intolerance suspected |
|
|
Term
|
Definition
INH, RIF, PZA, EMB QD x2m then
INH, RIF QD x4m |
|
|
Term
| # of drugs to add to a failing regimen |
|
Definition
| >1 - never add a single drug to a failing regimen |
|
|
Term
|
Definition
| Direct Observation Therapy - basically imprison person to ensure therapy adherence |
|
|
Term
|
Definition
| INH, PZA, ethionamide, cycloserine |
|
|
Term
|
Definition
INH and EMB with B6
RIF - meh (rarely causes birth defects) |
|
|
Term
|
Definition
INH and RIF require no changes
others require dose modification |
|
|
Term
| Isoniazid (INH) counseling points |
|
Definition
take on empty stomach
watch for signs of liver damage (yellowing skin, dark urine) |
|
|
Term
Rigampin (RIF) counseling points
(usual dose) |
|
Definition
10mg/kg (600mg)
take on empty stomach
decrease OC effectiveness
colors bodily fluids reddish-orange
watch for signs of liver damage (yellow skin, dark urine) |
|
|
Term
|
Definition
|
|
Term
| Pyrazinamide counseling points |
|
Definition
never monotherapy
w/ or w/o food
watch for liver damage (yellow skin, dark urine) |
|
|
Term
| Ethambutol counseling points |
|
Definition
take with food
may cause red-green color blindness - call MD
can be d/c'ed prn if SE or pt improving |
|
|
Term
| High prevalence of resistance areas (5) |
|
Definition
| NYC, Mexico, Asia, Baltic countries, former Soviet states |
|
|
Term
| Cases where resistance is suspected (7) |
|
Definition
pts who have received prior TB treatment
Patients from areas of high resistance
homeless, institutionalized, IV drug users, HIV+
+AFB smear after 1-2 months of therapy
+cultures after 2-4 months of therapy
pts who relapse
pts known to be exposed to MDR-TB |
|
|
Term
| Bedaquiline (indication, warning) |
|
Definition
indicated for INH or RIF resistant TB
QT prolongation |
|
|
