Shared Flashcard Set

Details

TB drugs
PIER SEA
7
Medical
Professional
04/26/2013

Additional Medical Flashcards

 


 

Cards

Term
isoniazid
Definition
Interferes with Mycolic acid synthesis via enyol reductase

(also used prophylactically health care/HIV)

may cause neuritis (give B6), hepatitis
Term
rifampin
Definition
DNA dependant RNA polymerase
Revs up CYP450s, turns urine orange

drug of choice meningtiococcal infections
Term
pyrazinamide
Definition
unknown mechanism, resembles nicotine
may cause hepatitis
Term
ethambutol
Definition
unknown mechanism,
may cause optic neuritis
Term
streptomycin
Definition
protein synthesis (aminoglycoside)
renal impairment and ototoxicity
Term
ethionamide
Definition
enoyl reductase/mycolic acid synthesis
may cause GI anorexia/nausea/vomiting
Term
Active TB
Definition
PIER
Pyrazinamide, isoniazid, ethambutol, rifampin

all are bacteriocidal rapidly growing, all are bacteriostatic slow growing
ALL CAUSE HEPATITIS TO SOME DEGREE

SEA (Strepto, ethionamide, A-p-aminosalicate)
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