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Definition
first line TB drug; cidal in growing org, narrow Mech: activated by mycobacterial catalase peroxidase->INH forms complex with NAD and NADP. INH-NAD->inhib mycolic acid syn. INH-NADP->inhib mycobact DHF Reductase Tox: INH neuropathy, hepatotox
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Definition
1st line TB drug Mech: binds mycobact RNA pol-> inhib transcription (Euk RNAP not affected) Induces P450 enzymes->increase metab of OC, hormones, coumadin
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Term
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Definition
1st line TB drug Mech: Inhib FA Synthetase 1-> inhib building blocks for mycolic acid synthesis-> inhib wall formation Wide distrib., hydrol/oxid in liver, renal elim Tox: flushing, transient arthralgia, gout, hepato
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Definition
1st line TB drug, static Mech: Inhib arabinogalactan syn and disrupts mycolic acid attachment in mycobact. cell wall Wide distrib, including CNS; renal elim Tox: optic neuritis, loss of visual acuity, loss of abil to perceive green
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Term
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Definition
Nucleoside RTI, Anti-AIDS Mech: AZT is phosphorylated by TK->AZT-TP->selective for HIV-RT; chain terminator Tox: bone marrow suppression, granulocytopenia, anemia, neurotox, N,V, headache, insomnia, myalgia
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Term
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Definition
Mech: RTI, chain terminator after uptake/Pation in host Contraindicated w/ AZT--antagonistic Tox: 20% periph neuropathy, 1% pancreatitis (incr w/ ddl), lactic acidosis
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Term
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Definition
Mech: RTI, DNA Chain terminator after cellular phosphorylation; some selectivity for HIV-RT and mitochondrial DNAP Can be used in place of AZT Tox: periph neuropathy, pancreatitis, neutropenia, steatosis, hepatotox.
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Term
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Definition
Mech: RTI, chain terminator Less active, less toxic than AZT Resistance arises, with cross resistance to ddI, abacavir; prevents resistance to AZT Used for HIB, hep B/C
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Term
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Definition
Mech: Guanosine nt analog, potent RTI, chain terminator; Metab by etoh dehydrog, elim urine Penetrates CNS Tox: Hypersensitivity rxns, fever, rash, Resp
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Term
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Definition
Mech: Pated to triphospate-> nt RTI; incorporated as chain terminator; weak inhib host DNAP Used in combo but not w/ tenofovir/abacavir/3TC Effective in resistant HIV strains 1 daily dose Tox: reduced
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Term
| Nevirapine, delavirdine, efavirenz |
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Definition
NNRTI Mech: metab in liver by P450 leading to induction or acute competition(nevirapine induces, delavirdine inhib P450 enzymes) Combine with NRTIs Cross res occurs bet NNRTIs Tox: Fever, nausea, CNS, hepato, rash
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Term
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Definition
Saquin-, indin-, riton-, nelfin-, ampren-, atazan-, tipran-, darun-, fosampren-, topin-avir Mech: prevent cleavage of HIV protein precursors by HIV encoded aspartate proteases Metab by hepatic P450 enzymes Tox: NVD, ab pain, incr liver enzymes, diabetes, incr cholesterol, renal failure
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Term
| Enfuvirtide (Fuzeon, T-20) |
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Definition
Entry Inhibitor Mech: Binds HIV surface prot gp41, precents binding to T-cells at CD4 Tox: NVD, neuropathy, insomnia, fatigue, depression
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