Term
factors that affect a drug's ADME |
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Definition
-solubility -size -route of administration -functional groups |
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Term
drug characteristics that favor absorption |
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Definition
-uncharged -nonpolar -right pka and right ph -low mw -lipid soluble |
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Term
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Definition
drug is eliminated unchanged in urine, bile, exhaled air, sweat, breast milk, and saliva |
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Term
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Definition
drug is changed to facilitate elimination in urine and bile |
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Term
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Definition
removal of drug from plasma. sum of excretion and biotransformation. |
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Term
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Definition
drugs are foreign substances |
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Definition
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Definition
transferases, GSH conjugase, alcohol/aldehyde dehydrogenase, hydrolytic enzymes, and other oxidative enzymes |
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Term
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Definition
>40% of the same amino acids |
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Term
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Definition
> 60% of same amino acids |
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Term
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Definition
members of a subfamily that each have 60% of the same amino acids |
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Term
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Definition
phenobarbital, rifampin, tobacco |
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Definition
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Definition
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Definition
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Definition
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Definition
barbituates, rifampin, st. john's wort |
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Definition
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Definition
fluconazole, ketoconazole |
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Definition
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Definition
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Definition
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Term
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Definition
ketoconazole, itraconazole, fluconazole, cimetidine, grapefruit juice |
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