Shared Flashcard Set

Details

Systems Pharmacology
Effects of Agonists/Antagonists/Spare Receptors/QD Curves
11
Biology
Graduate
11/13/2011

Additional Biology Flashcards

 


 

Cards

Term
EC50
Definition
-concentration that produces 50% effect
-POTENCY
Term
Emax
Definition
-EFFICACY
Term
competitive antagonists shift DR curve
Definition
to the right WITHOUT affecting max response
Term
partial agonists can act as
Definition
antagonists
Term
spare receptors
Definition
-max effect does NOT require occupation of all receptors
Term
in the presence of spare receptors
Definition
Kd is greater than EC50
Term
potency and efficacy change with non competitive antagonists only
Definition
in the presence of spare receptors
Term
competitive antagonists change
Definition
potency only
Term
noncompetitive antagonists change
Definition
efficacy only
Term
irreversible active site antagonists change
Definition
efficacy only
Term
TI
Definition
TD50/ED50
Supporting users have an ad free experience!