Term
| regulatory protein targets |
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Definition
-enzymes
-ion channel proteins
-receptor proteins
-transporters |
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Term
| non-specific interactions |
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Definition
-pH
-osmolarity
-surfactant (decreases ST)
-protein denaturation
-alter membrane fluidity
-selective toxicity |
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Term
| bonds usually involved in drug-receptor binding |
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Definition
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Term
| bonds NOT usually involved in drug receptor binding |
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Definition
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Term
|
Definition
-bind specifically
-receive/process extracellular signals
-role in intracellular communication via chemical messengers
-change activity of intracellular enzymes |
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|
Term
| cell biologist classification of receptors |
|
Definition
-enzyme ligand
-ligand-gated ion channels
-G-protein coupled
-nuclear receptors |
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Term
|
Definition
-1900s
-isolated muscle fibers
-2 compounds competing for a third unknown substrate |
|
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Term
|
Definition
-1st to use term "receptor"
-microbiologist
-stereoselectivity
-lock and key |
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Term
| binding properties of receptors |
|
Definition
-Drug specificity
-Reversibility
-Stereoselectivity
-Saturability
-Tissue Specificity |
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Term
|
Definition
| -chemicals that bind to receptors |
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Term
|
Definition
-how well a ligand binds to a receptor
-nothing to do with what effect the ligand has |
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Term
|
Definition
| measure of the effect produced after a ligand binds |
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Term
|
Definition
| a ligand is potent if it produces an effect at a low concentration |
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Term
| determines binding in the body |
|
Definition
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|
Term
| determines binding in a dish of cells |
|
Definition
-specificity
-solubility
-stability |
|
|
Term
| purpose of radioactive saturation bind study |
|
Definition
| -determine affinity and number of receptors |
|
|
Term
|
Definition
-dissociation constant
-measure of affinity (inversely)
-concentration of drug where 50% of receptors are complexed with drug |
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