Term
|
Definition
-rifampin
-barbituates
-tobacco
-ethanol
-St. John's wort |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| competitive inhibition is _____ dependent |
|
Definition
| concentration and affinity |
|
|
Term
|
Definition
-cimetidine
-fluconazole
-grapefruit juice |
|
|
Term
| grapefruit juice inhibits |
|
Definition
|
|
Term
| Asians are poor metabolizers of |
|
Definition
|
|
Term
|
Definition
-metabolizes 15% of clinically useful drugs (Omeprazole,Diazepam)
-drugs should be prescribed initially in lower doses
-polymorphed form helps trest ulcers |
|
|
Term
|
Definition
-metabolizes nicotine
-activates carcinogens in tobacco smoke
-Asians may have less activity |
|
|
Term
|
Definition
-78 variants
-range from poor to ultra rapid
-20% of clinically useful drugs
-antidepressants
-antipsychotics
-beta blockers
-codeine (prodrug of morphine) |
|
|
Term
|
Definition
|
|
Term
|
Definition
-UGT
-accumulation of bilirubin |
|
|
Term
|
Definition
| -CYP1A2 (petroleum, charcoal foods,cigarette smoke) |
|
|
