Term
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Definition
-conjugation reactions (compound is joined to a molecule)
-makes more water soluble
-maybe conjugation enzymes exhibit polymorphisms |
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Term
| most drugs metabolized by |
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Definition
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Term
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Definition
-UGTs
-liver and intestinal epithelia
-UDPGA is cofactor
-prefers OH, NH2, COOH |
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Term
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Definition
-SULTs
-liver cytosol
-prefs OH groups
-lesser group - NH2
-PAPS is cofactor |
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Term
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Definition
-NAT
-in liver
-prefers primary NH2
-Acetyl CoA is cofactor
-DECREASE water solubility
-products undergo hydrolysis before elimination |
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Term
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Definition
-ONS methyltransferase
-OH, NH2, SH
-SAM-e is cofactor
-common with NE,DA
-DECREASE water solubility |
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Term
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Definition
-two steps two enzymes
-COOH
-"activated" by combining with ATP and acetyl CoA (acyl CoA synthetase)
-CoA derivatives are conjugated with glycine or glutamine (N-acyltransferases)
-very water soluble product |
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Term
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Definition
-GST
-electrophilic groups
-very important for detoxification of toxicants and carcinogens |
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Term
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Definition
-major pathway UGT,ST detoxification
-minor pathway CYP2E1, forms NAPQI, GST detoxifies |
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Term
| cases of liver failure caused by acetaminophen |
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Definition
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Term
| antidote for liver poisoning |
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Definition
| N-acetyl cysteine (Mucomyst) |
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Term
| examples of activation by conjugation |
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Definition
-morphine
-minoxidil
-procalnamide |
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Term
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Definition
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