Term
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Definition
-introduce a new functional group
-facilitate phase 2
-lipid soluble to more water soluble (facilitates elimination)
-most catalyzed by microsomal enzymes
-most occur in hepatocytes |
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Term
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Definition
-mixed function oxidases
-CP450 enzymes
-FMO (Flavin monooxygenase) |
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Term
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Definition
| oxidation of alcohols and deamination reactions |
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Term
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Definition
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Term
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Definition
-absorbance peak at 450 nm
-reduced CYP450 complexed with carbon monoxide |
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Term
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Definition
-CP450 protein
-NADPH-CYP450 reductase
-phospholipids |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
| -members of a subfamily that each have 60% of same amino acids |
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Term
| number of CYP450 families and functional genes in humans |
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Definition
-18 families
-57 functional genes |
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Term
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Definition
-1,2,3 contain most important ones
-MW is 45-60kDa
-2+ enzymes can catalyze the same type of reaction |
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Term
| most clinically used drugs metabolized by |
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Definition
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Term
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Definition
-important in steroid (Fatty) biosynthesis (CYP2 too)
-fatty acid metabolism
-bile acid biosynthesis
-Vit. D degradation |
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Term
| drugs that inhibit CYPs can also disrupt |
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Definition
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