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Systems Pharmacology
Signal Transduction GPCRs
7
Biology
Graduate
11/13/2011
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Term
GPCRs
 Definition
-7 alpha helices
-involved in vision, smell, behavior,immune system, ANS
Term
G protein basics
 Definition
-heterotrimeric
-alpha
-beta,gamma
Term
Gs
 Definition
-stimulatory
-activates Ca and AC
-stimulates cAMP formation
-ex. beta-andrenergic receptor
Term
Gi
 Definition
-inhibitory
-inhibits AC
-inhibits cAMP formation
-activates K+ channels
-opioid receptors
Term
Gq
 Definition
-activates PLC
-increases Ca
Term
G0
 Definition
inhibits Ca
Term
G12/13
 Definition
diverse ion transporter interactions
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