Shared Flashcard Set

Details

Title

Systems Pharmacology

Description

Drug Metabolism Overview

Total Cards

Subject

Biology

Level

Graduate

Created

10/21/2011

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Additional Biology Flashcards

Term

excretion

Definition

-drug eliminated unchanged

Term

biotransformation

Definition

drug is changed to facilitate elimination

Term

total clearance

Definition

-removal of drug from plasma
-sum of excretion and biotransformation

Term

where drugs are mostly metabolized

Definition

liver

Term

chemical properties of a clinically useful drug

Definition

-stable dosage form
-not substrate for first pass metabolism
-low plasma protein binding
-soluble
-low MW
-effective and safe