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Systems Pharmacology II
Parasympathetic NS
16
Biology
Graduate
01/29/2012

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Term
role of PSNS
Definition
-promotes maintenance activities and conserves body energy
-pupils are constricted for close vision
Term
PSNS innervate blood vessels?
Definition
-no!
-indirect mechanism
Term
muscarinic receptors
Definition
-GPCRs
Term
Gq
Definition
-M1,M3,M5
Term
Gi
Definition
M2,M4
Term
Ach is made from
Definition
-acetyl CoA and choline by ChAT
Term
Ach is degraded by
Definition
AChE into acetate and choline
Term
choline is transported back to presynaptic neuron via
Definition
HAChT
Term
cell make its own choline?
Definition
NO
Term
blocking Ach
Definition
-block transport of choline
-block entry of Ach
-Botox blocks Ca
Term
page 15?
Definition
Term
what happens when a postsynaptic nicotinic receptor is constantly activated?
Definition
-desensitization and upregulation
Term
nicotinic receptor binding and channel opening
Definition
-channel opening/closing are much SLOWER than Ach binding
-can have 2 Ach bound and be closed
-reversal of desensitization is time dependent
Term
location of M2
Definition
heart
Term
location of M3
Definition
smooth muscle and glands
Term
eye?
Definition
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