Term
|
Definition
-1st line
-MOA depends on drug
-AS A GROUP BLOCK FEWER D2 AND MORE 5HT2A
-can alleviate negative symptoms
-LESS propensity to produce motor SE and hyperprolactinemia
-LOWER affinity for muscarinic, adrenergic, and histamine receptors than typicals |
|
|
Term
| D2 and 5-HT receptor occupancy |
|
Definition
|
|
Term
|
Definition
-clozapine
-olanzapine
-risperidone |
|
|
Term
|
Definition
-proven to be effective with suicidal behavior
-D4, 5-HT2A, H1
-WEIGHT GAIN IS COMMON
-RISK OF SEIZURES AND AGRANULOCYTOSIS LIMITS USE
-CYP1A2 (SMOKING) |
|
|
Term
|
Definition
-5-HT2A, 5-HT2c,D1-4
-SEDATION, ORTHOSTATIC HYPOTENSION AND WEIGHT GAIN ARE COMMON
also used to treat acute manic episodes and off label use to PREVENT pyschosis
-CYP1A2 |
|
|
Term
|
Definition
-5-HT2A
-low doses (less than 8 mg, see EPS?) |
|
|
