Term
|
Definition
-D2 RECEPTOR ANTAGONISM
-responsible for therapeutic effect and adverse effects
-antagonism of 5-HT, cholinergic, histamine and adrenergic receptors
-do not know if blockade of these receptors contributes to alleviation of symptoms |
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Term
| D2 blockade and clinical potency |
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Definition
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Term
|
Definition
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|
Term
| which causes anticholinergic SE |
|
Definition
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Term
|
Definition
-derived from antihistamines
-minor modification of promethazine
-differ in structure of amino side chain |
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Term
|
Definition
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Term
|
Definition
| medium potency CARDIOTOXICITY |
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Term
|
Definition
| -high potency, inc EPS, dec sedation and hypotension |
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|
Term
| which phenothiazine has EPS |
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Definition
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Term
| which phenothiazine antipsychotic has anticholinergic SE |
|
Definition
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Term
|
Definition
-chlorpromazine
-thioridazine
-fluphenazine
-trifluoperazine
-prochloperazine |
|
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Term
|
Definition
-aliphatic
-binds D2 M1
-many SE
-othostatic hypotension, anticholinergic SE
-1st antipsychotic |
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Term
|
Definition
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Term
|
Definition
-piperazine
-D2
-IM injection
-sesame oil vehicle |
|
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Term
|
Definition
-piperazine
-highest incidence of EPS |
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Term
|
Definition
|
|
Term
|
Definition
-haloperidol
-derived from meperidine
-D2>D1=D4>alpha1>5HT2 |
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