Term
| What word defines a period of active demyelination often referred to as a "flare-up"? |
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Definition
Exarcebation: period of active demyelination aka flare-up
*Onset of neurological symptoms from several hours to a few days*
*Exarcebation may last up to 6-8 weeks & resolves over 2-3 months* |
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Term
| What term describes the period between exarcebations or also to defined complete disapperance of the disease? |
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Definition
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Term
| What is the average rate of exarcebations for people with MS? |
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Definition
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Term
| What is an active plaque? |
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Definition
| Active plaque = macrophage and lymphocytes attack oligodendrocytes |
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Term
| What is an inactive plaque? |
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Definition
| Inactive plaque = demyelinated axon with gliosis (astroctyes) filling gap (harder) |
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Term
| Where are plaques more likely to be found? |
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Definition
| Although random, plaques tend to be more dense around BV and ventricles |
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Term
| What do macrophage and lymphocytes target? |
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Definition
Myelin basic protein
*macrophage and lymphocyte attack and mistake this as an antigen* |
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Term
How long does demyelination take?
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Definition
1-2 weeks
*transmission in other parts of CNS is dependant on timely stimulus appropriate signals on affected pathways; demyelination = transmission is ineffective* |
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