Term
| What are the three categories of hormones? |
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Definition
Peptides and proteins
Tyrosine derivatives
Steroids |
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Term
| What are the components of a signal recognition complex for protein hormone synthesis? |
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Definition
Signal peptide
Signal recognition particle
Docking protein
Signal sequence receptor |
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Term
| Movement of the secretory granules to cell surface, fusion with the plasma membrane, and release into the extracellular space is initiated by receptor-mediated events that result in increased what? |
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Definition
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Term
| What is the most common form of hormone regulation? |
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Definition
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Term
| What is the metabolic clearance rate (MCR)? |
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Definition
| The volume of plasma cleared of hormone per unit time |
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Term
| When is the influence of a hormone is greatest? |
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Definition
| When the receptors are undersaturated |
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Term
| What promotes the reassociation of the a-subunit of a G protein with its By-subunit? |
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Definition
| Hydrolysis of the bound GTP to GDP |
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Term
| What are the effects of Gs, Gi, Gq, and Gt? |
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Definition
Gs - stimulation of adenylyl cyclase
Gi - inhibition of adenylyl cyclase
Gq - stimulation of phospholipase C
Gt - activation of cGMP phosphodiesterase |
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Term
| PLCbeta can generate DAG from what two sources? Which one is probably more important? |
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Definition
Phosphoinositide PIPs and phosphatidylcholine PC
PC is probably more important, as their is much more PC than PIP2 |
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Term
| What happens when an EGF receptor becomes bound to its ligand? |
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Definition
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Term
| Structurally, what do steroid receptors contain? |
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Definition
A DNA binding domain with a zinc finger; 2 hormone binding domains; a hypervariable region between the NH2 terminus and the DNA binding domain
Steroid receptors are often found associated with heat shock protein 90 (HSP90) |
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