Term
| What is the average Alveolar Oxygen Partial Pressure? |
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Definition
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Term
| What two factors can affect the concentration gradient of oxygen from atmosphere to blood? |
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Definition
1. Total Barometric Pressure
2. Partial Pressure of oxygen will vary as a function of its percentage composition (humid vs. dry air) |
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Term
| What are two factors that affect the rate of diffusion? |
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Definition
1. Driving Force or differences in partial pressure of oxygen between two compartments.
2. Nature of the barrier that oxygen must diffuse across. |
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Term
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Definition
States that flow of any gas is related to its diffusing capacity (DL) in the barrier and its concentration gradient across the barrier (P1 - P2).
V = (DL) * (P1 - P2) |
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Term
| What are the components of the Diffusion Capacity? |
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Definition
1. molecular weight of the gas
2. solubility in water |
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Term
1. What is pulmonary transit time?
2. What is the time for saturation of capillary blood with oxygen? |
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Definition
1. 0.75 seconds
2. 0.25 seconds |
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Term
| How many ml of O2 will dissolve in each 100ml of blood per 100mHg of pressure? |
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Definition
| 0.003 ml - Obviously not enough to deliver the appropriate amount of O2 to tissues. |
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Term
| What is the delivery of O2 to tissues with hemoglobin? |
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Definition
| With cardiac output of 500ml/min O2 delivery will be appoximately 1000ml of O2/min |
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Term
| What is the average blood hemoglobin concentration? |
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Definition
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Term
| How much O2 can one gram of hemoglobin bind? |
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Definition
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Term
| Affinity of Hb for O2 is less as the curve shifts to the _______. |
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Definition
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Term
| Moderate shifts to the right of the Hb curve lead to (increased/decreased) oxygen unloading in the tissues. |
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Definition
| increased. This is because Hb has a lower affinity for O2 as the curve shifts to the right. However, as long as alveolar PO2 is above 70, the slightly less affinity does not affect loading in lungs due to the sigmoid shape of the curve. |
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Term
| What are some of the factors that affect affinity of Hb for O2? |
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Definition
Temperature - higher temperature shifts curve right
pH - lower pH shifts curve to the right
2,3 DPG - more shifts curve to right
Carbon Dioxide - more shifts curve towards right
Genetics
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Term
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Definition
| Another heme monomer that does not demonstrate cooperativity with regard to oxygen affinity. |
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Term
| T/F: Carbon Monoxide has a greater affinity for hemoglobin than Oxygen? |
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Definition
| True. Thus CO decreases the delivery of oxygen to the tissues. |
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Term
| What is hyperoxia and what are some negative affects of it? |
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Definition
Too much oxygen delivery.
Superoxide formation. |
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Term
| Where is erythropoeitin formed? |
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Definition
| Formed in the kidneys in response to stimuli related to the oxygen carrying capacity of blood. |
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Term
| What is the timeline for RBC replacement in response to EPO? |
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Definition
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