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Systems 3
Adrenal axis drugs
9
Biology
Graduate
02/06/2013

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Term
fludrocortisone
Definition
-tx hypoaldosteronism
-SE HF, thrombophlebitis, secondary hypocortisolism, inc ICP
Term
spironolactone
Definition
-tx primary aldosteronism
-SE Gi bleed, agranulocytosis, SLE
-long half life
Term
eplerenone
Definition
-tx primary aldosteronism
-SE SE inc K, Gi bleed, agranulocytosis, SLE
-more selective
-shorter half life
Term
mitotane
Definition
-tx cushings syndrome unlabeled
-MOA adrenalcortical mitochondria tox
-SE visual disturbances, hemorrhagic cystitis
-long half life
-hepatic metabolism
-PO
Term
aminoglutethimide
Definition
-tx cushings syndrome LABELED
-MOA inhibits side chain cleavage enzyme
-SE cortisol insuff, agranulocytosis, leukopenia, neutropenia, pancytopenia
-hepatic metabolism
-PO
Term
ketoconazole
Definition
-tx cushings syndrome LABELED
-MOA inhibits side chain cleavage
-SE gynecomastia, dec libido
Term
metyrapone
Definition
-tx cushing syndrome and diagnostic of HPA axis
-SE cortisol insuff
Term
mifepristone
Definition
-tx life threatening glucocorticoid levels
-MOA progesterone R antagonist
-SE prolonged bleeding time, bacterial infections
Term
hydrocortison
Definition
-tx adrenal insuff
-need to dose adjust during times of stress
-SE immunosupp, cataracts , depression, euphoria, oesteoporosis, growth supp in kids, muscle atrophy
-PO IV IM
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