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Systemic diseases/Exanthem&Enanthem
Dermatology
18
Dentistry
Professional
12/03/2013

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Cards

Term
Systemic Lupus
Definition
Skin & systemic symptoms; nasal and oral ulcers; red-violaceous rash-malar and other sun-exposed areas; alopecia, arthritis, serositis; immunologic (auto-immune)
Term
Neonatal lupus
Definition
Photosensitive cutaneous disease; shortly after birth, resolves in 4-6 mos; heart block usually permanent; Anti-Ro antibody leads to rash; mother may be asymptomatic
Term
Subcutaneous lupus
Definition
Skin: annular or papulosquamous; usually little scarring or atrophy; photosensitivity over 90%; Ro+; rarely severe systemic disease
Term
Dermatomyositis
Definition
Inflammatory myopathy and cutaneous findings; proximal symmetric muscle weakness (hard to reach arm over head and go upstairs); photo-related findings: heliotrope (flower, light violet color) rash and Gottron's papules (over knuckles) are pathogenesis; malar rash and poikilodema are common; hair loss; very steroid sensitive; internal malignancy (GI 6-60%); often misdiagnosed w/ lupus
Term
Progressive systemic sclerosis
Definition
Cutaneous and internal organ fibrosis; skin on hands tighten so much pt can't make fist, ulcers on knuckles; telangiectasia on face, will have trouble opening mouth; Raynaud's phenomenon; Women 15 times more affected; severe, disabling skin (sclerodactyly) esophageal trouble swallowing, kidney and lung; death more common pulmonary fibrosis
Term
Acanthosis Nigricans
Definition
Types: familial, endocrine, idiopathic, malignancy; elongation of rete ridges, folding of epi, hyperpigmentation very common
Term
Sarcoidosis:
Definition
Multisystem disorder; unknown cause; lungs (most common, lymph nodes, liver, spleen; skin papules, nodules, plaques, EN; lupus  pernio - papules around nasal ala; eyes - uveitis; reaction patterns usually want pts to be seen by ophthalmology
Term
Tuberous sclerosis
Definition
Auto dom, epilepsy 75%, mental retardation 50%; angiofibromas, ungual, ash leaf macules, shagreen patch; CNS, renal, cardiac, and pulmonary tumors; periungual fibromas - tubular sclerosis; angiofibromas presentation in TS
Term
Neurofibromatosis:
Definition
Much more common; freckling in NF, start earlyl and look like freckles; AD 4:10,000 many mutations; diagnostic criteria - 6 or more cafe-au-lait spots greater than 5 mm 2 or more NFs, axillary or inguinal freckling, optic gliomas or Lisch nodules; plexiform neuroma, button hole sign, intellectual handicap; many other organ systems may be involved
Term
Necrobiosis Lipoidica (yellowish color) diabecticorum
Definition
Very common rahs (very thin, inflammatory reddish border); assoc with microangiopathy of DM, 1/3 DM; 1/3 have glucose intolerance; 1/3 have normal glucose; good control of glucose does NOT help improve the skin
Term
Hand-foot-and-mouth disease
Definition
Caused by coxsackie virus; usually occurs in children less than 10 y/o; fever; short only 6 days, vesicular eruption, lesions often on lateral fingers and toes 1/ an elliptical; Enanthem: vesicles do rupture, most common location on lateral part of tongue
Term
Varicella
Definition
VZvirus, prodrome of fever, headache, and malaise; highly contagious; exanthem: tear-drop shaped vesicles on erythematous base, lesions can spread from trunk to extremities, lesions progress to pustules and later crusted lesions; Enanthem: vesicular lesions occur which may become pustular, can rupture and become more like ulcers
Term
Scarlet fever
Definition
Strep pyogenes, erythrogenic toxin produced, fever, incubation 2-5 days; exanthem: erythema accentuated in fold areas, Pastia's sign (petechiae), "Sand-paper" type eruption, desquamation; enanthem: pharyngitis, erythematous oropharynx, exudates, cervical lymphadenopathy, petechiae on soft palate, strawberry tongue
Term
Measles (Rubeola)
Definition
Paramyxovirus (RNA); highly contagious, prodrome of cough, coryza, conjunctivitis, and Koplik's spots; very high fever, incubation of 10-14 days; exanthem: maculopapular eruption beginning at scalp line and descending down the face; enanthem: Koplik's spots - white or bluish grey 1 mm in size buccal mucosa opposite lower molars most common; may see erythema on palate and posterior pharynx
Term
Infectious mononucleosis
Definition
EBV, Prodrome of headache, malaise, fever, and pharyngitis; incubation of 33-49 days; exanthem occurs in 35% of pats, accompanying strep pharyngitis in 20-25%; exanthem: erythematous maculopapular lesions, initially on trunk and then spreads, areas of confluence can occur, pruritis, fades in 3-4 days; enanthem: macules or petechiae of palate, erythema of oropharynx, findings of strep pharyngitis when present
Term
HSV
Definition

 

Exanthem: direct inoculation of any cutaneous surface; prodrome of itching, stinging, or burning, grouped vesicles with erythematous surround; many become vesiculopustular lesions; enanthem: vesciular lesions or oropharynx which may rupture, lesions more anterior than some other viruses, involvement of gum tissue, lymphadenopathy; diagnosis: tzanck smear, fluorescent antibody, culture

 

Term
Rocky Mountain fever
Definition
Caused by Rickettsia ricketsii, history of tick exposure; incubation 2-14 days; fever; severe headache, confusion, N&V; photophobia, exanthem: present in 90% of pts, erythematous macules and papules initially, later petechial or purpuric lesions; lesions initially on palms and soles then spread centrally
Term
Gianotti-Crosti syndrome
Definition
Associated w/ viral illness; virus associated exanthem; most often in children aged 2-6 generalized lymphadenopathy, infreq pruritic; clinical findings: papular lesions, urtical lesions, less often vesicular or papulovesicular, more concentrated on arms and legs, Koebner phenomenon
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