Term
| what is the basic structure of a catechoalmine |
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Definition
| it is a aromatic phenylethylamine with two hydroxyl groups |
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Term
| primary mechanism for clearing catecholamines from synapse is |
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Definition
| diffusion away. Then reuptake and metabolism |
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Term
| COMT is found the in cytoplasm or plasma |
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Definition
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Term
| do MAO or COMT methylate NE and EPI |
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Definition
| COMT methylates. While MAO deaminates |
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Term
| the principal end metabolite of EPI and NE is |
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Definition
| 3 methoxy - 4- hydroxmandelic acid AKA VMA or vanillymandelic acid |
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Term
| Describe the steps of tyrosine to NE |
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Definition
Tyrosine broken down by hydroxylase to DOPA
DOPA broken down by L aromatic acid decarboxylase to dopamine
Dopamine broken down in the vesicle by Beta hydroxylase to NE |
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Term
| Are alpha 2 on the presynapse positive or negative feedback |
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Definition
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Term
| Which receptor Alpha 1,2 or beta 1,2 is responsible for hyperpolarization of membranes in CNS and platelet aggregation |
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Definition
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Term
| why is profound rebound hypotension associated with chronic clonidine use |
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Definition
| chronic alpha 2 agonism causes dilation which is countered by the body producing more renin and angiotensin. When you remove the drug like clonidine then you shift the balance. |
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Term
| presence of ____ converts NE to EPI |
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Definition
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Term
| does dopamine or dobutamine have more arrythmias associated with it |
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Definition
| dobutamine more than dopamine |
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Term
| treat bronchospasms with what type of receptor drug |
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Definition
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Term
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Definition
| works by inhibiting phosphodiesterase. That enzyme is normally used to break down cAMP. So if we inhibit this enzyme then there is MORE cAMP. Which means more adrenergic effect. |
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Term
| milirinone acts on what receptors |
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Definition
| stimulates B1 and Beta 2. |
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Term
| SNS nerves come from what parts of spine |
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Definition
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Term
| the vagus nerve is responsible for what % of all parasympathetic activity |
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Definition
| 75% of all PNS is from vagus nerve |
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Term
| what are the two types of nicotinic recpetors and what are the difference between them |
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Definition
Nn: found at all autonomic ganglia
Nm: found at the neurmusclar junciton |
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Term
| Muscarininc receptors found a neural tissue are this subtype |
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Definition
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Term
| AcH is in what chemistry class |
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Definition
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Term
| Breakdown of AcH results in what two products |
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Definition
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Term
| mneumonic for lots of AcH |
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Definition
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Term
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Definition
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Term
| dopamine cahnged to NE by |
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Definition
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Term
| insulin secretion is pns or sns |
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Definition
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Term
| piloerection is SNS or PNS |
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Definition
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Term
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Definition
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Term
| the uterus is contracted or relaxed by the SNS |
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Definition
| relaxed. HENCE WHY beta 2 agonist are TOCOLYTIC |
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Term
| Sweat glands are serviced by SNS or PNS? Why neurotransmiter is used |
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Definition
| by SNS but acetylcholine is released! |
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Term
| Liver stimulus by SNS vs PNS results in |
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Definition
SNS: glycogenolysis
PNS: glycogen synthesis |
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Term
| does PNS or SNS release insulin |
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Definition
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