Term
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Definition
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Definition
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Term
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Definition
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Term
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Definition
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Term
Phentolamine
Adrenergic activity? Blood pressure tracing before and after epinephrine? |
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Definition
ɑ1, ɑ2 antagonist
Blood pressure tracing: phentolamine
Vasodilation, decrease in B.P.
Blocks constriction by ɑ receptors maintained by E
Blood pressure tracing: epinephrine, phentolamine
Initial rise (?), decrease in blood pressure
Treatment for hypertension by vasodilation |
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Term
Phentolamine
Adverse effects? |
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Definition
| Orthohypotension Increased GI motility Nasal stuffiness |
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Term
Propanolol
Adrenergic effects? |
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Definition
Decrease in contractile force and heart rate
β1
Increase in blood pressure retained after epinephrine administration
ɑ1 vasoconstriction |
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Term
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Definition
β1, β2 antagonist
Highly susceptible to first pass effect, t1/2 = 4 hrs
Lipid soluble, plasma protein bound
Eliminated by hepatic metabolism |
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Term
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Definition
Hypertension by decreased heart rate and contractility and renin release
Arrhythmias, when used in combo with a vasodilator
Ischemic heart disease |
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Term
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Definition
Bronchoconstriction (β2 receptor block)
Congestive heart failure
Bradycardia
Rebound hypertension |
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Term
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Definition
β1 antagonist
Cardiac effect only |
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Term
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Definition
Partial β antagonist
Lesser bronchoconstriction
Less rebound hypertension
Less bradycardia |
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Term
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Definition
Renal elimination
t1/2 = 14-24 hrs |
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Term
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Definition
β1 antagonist
t1/2 = 10 mins |
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Term
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Definition
NE synthesis inhibitor (competitive)
Tyrosine hydroxylase
Tyr → DOPA → dopamine → NE |
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