Term
| What is the rate limiting enzyme in the synthesis of catecholamines? |
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Definition
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Term
| What enzyme converts dopamine to NE, and where is it located? |
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Definition
Dopamine hydroxylase
in the vesicle |
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Term
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Definition
| is within the vesicle to help package and sort the catecholamines |
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Term
| How do recycled catecholamines get brought back into the vesicles? |
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Definition
secondary active transport
Hydrogen exchange secondary to an H atpase |
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Term
| What is the affinity and capacity for UPTAKE 1 and 2? |
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Definition
UPTAKE 1 has high affinity low capacity
UPTAKE 2 has low affinity high capacity |
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Term
| What catecholamines does UPTAKE 1 and UPTAKE 2 prefer? |
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Definition
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Term
| What two enzymes metabolize catecholamines? |
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Definition
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Term
| What G protein and secondary messenger system does alpha 1 work through? |
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Definition
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Term
| What G protein does alpha 2 work through? |
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Definition
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Term
| What G protein do B1 and B2 both work through? |
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Definition
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Term
| What is the non neural beta receptor? |
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Definition
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Term
| What two G proteins does B3 work by? |
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Definition
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Term
What catecholamine do all the receptors except B3 have a high affinity for?
What is it for B3? |
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Definition
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Term
| What process happens to the receptors in the heart of a CHF patient? |
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Definition
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Term
| What enzyme phosphorylates GCPR during desensitization? |
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Definition
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Term
| What happens to the efficiency of the heart when catecholamines are increased? |
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Definition
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Term
| Name three states in which catecholamines would be in high concentration? |
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Definition
cocaine
severe anxiety
pheochromocytoma |
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Term
| What two instances can the adernergic receptors of the heart be supersensitive? |
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Definition
post MI
using general anesthetics |
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Term
| What three mechanisms lead to the downward spiral in CHF? |
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Definition
ventricular enlargement
ventricular dysfunction
chronic vasoconstriction |
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Term
| What is the best B blocker to treat CHF and why? |
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Definition
| carvedilol b/c it works against B1 B2 and a1 so get less vasoconstriction |
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