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Swedish Paramedicine
Cell structures and function: 225
126
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Professional
07/02/2011

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Term
Membrane
Definition
Contains Cellular contents; regulates what enters and leaves the cell
Term
Cytoplasm
Definition
Surrounds and supports organelles; medium through which nutrients and waste move
Term
Nucleus
Definition
Contains genetic information; control center of the cell
Term
endoplasmic reticulum
Definition
Chain of canals and sacs that wind through the cytoplasm; moves substances and proteins through the cell. Contains ribosomes where protein is synthesized
Term
Mitochondria
Definition
Convert energy in nutrients to ATP (power plant of the cell)
Term
Golgi Apparatus
Definition
Packages protein in membrane; puts the finishing touches on protein
Term
Ribosomes
Definition
Site of protein synthesis, are the structures that make ER rough as opposed to smooth.
Term
Lysosomes
Definition
"Housekeeping" within the cell; digests cell waste through powerful enzymes
Term
Cytoskeleton
Definition
provides intracellular shape and support
Term
Centrioles
Definition
Help separate the chromosomes during mitosis
Term
Diffusion
Definition
The process of particles moving from an area of higher concentration to an area of lower concentration along a concentration gradient
Term
Facilitated diffusion
Definition
Passive transport where particles move from high to low concentration, However; in this type the molecule cannot enter the cell without the assistance of a carrier protein
Term
Osmosis
Definition
Passive transport in which the particles do not transfer but the fluid (solvent) does
Term
What is the universal solvent
Definition
water
Term
Tonicity
Definition
the ability to draw or give water
Term
osmotic gradient
Definition
The difference in concentrations from one side of a selectively permeable membrane to the other
Term
Active transport
Definition
Ions and molecules move against their concentration gradient, through the use of energy
Term
Differentiation
Definition
the process by which a cell becomes specialized for a specific purpose
Term
What are the four types of tissue found in the body
Definition
epithelial, connective, muscle, nervous
Term
Epithelial
Definition
Classified by shape, this tissue type has four functions and is found on the surface of the body and the interior of hollow organs
Term
What are the four functions of epithelial cells
Definition
protection (skin), absorption (small intestine lining), secretion (exocrine,endocrine), excretion (sweat)
Term
Connective Tissue
Definition
the most abundant type of tissue in the body, separated by a matrix
Term
What are the seven subcategores of Connective tissue
Definition
adipose, areolar, fibrous (tendons/ligaments), Cartilage (chondrocytes), Bone, Blood, Hemopoietic
Term
What are the three types of muscle tissue
Definition
Smooth, Cardiac, skeletal
Term
What are the four basic properties of muscle tissue
Definition
Excitablility (respond to a stimulus); Contractility(actively shorten in length); Conductivity(Conduct an impulse); elasticity(ability to lengthen)
Term
Neuron
Definition
One of two types of nerve cells, conducting cells of nervous tissue. (dendrites, axon, cell body)
Term
Neuroglia
Definition
Supporting structure of nervous tissue that does not conduct an impulse
Term
atrophy
Definition
the shrinkage of cells; i.e. when the uterus shrinks after birth, or when arm muscles shrink in a cast
Term
hypertrophy
Definition
refers to the increase in the size of a cell, tissue, or organ. Happens in response to an increase in workload (weight lifting)
Term
Hyperplasia
Definition
the result of cellular division that occurs to increase the number of a specific type of cell, can be because of normal growth or tumors
Term
Dysplasia
Definition
Sometimes referred to as atypical or abnormal hyperplasia, cells take on an abnormal shape, size, and organization as a result of ongoing irritation or inflammation
Term
Metaplasia
Definition
the transformation of one type of mature differentiated cell into another type of mature differentiated cell. i.e. the change that occurs in the trachea of long term smokers
Term
Hypoxia
Definition
The most common and most studied type of cell injury
Term
Virulence
Definition
The term used to refer to the relative patho genicity of an infectious agent, aka, the relative ability of the agent to damage the host.
Term
normal flora
Definition
a type of non-threatening bacteria found in the body, necessary for function
Term
Crenation
Definition
when cells shrink because water is being sucked out of them.
Term
Sodium
Definition
primary extracellular cation
Term
What is the normal range for end-tidal CO2
Definition
33-43
Term
How do viruses differ from bacteria
Definition
They survive and replicate by takin over the metabolic machinery of the host cell. They hide inside the cell and do not produce endo/exo toxins
Term
mycoses
Definition
diseases caused by fungi
Term
Parasite
Definition
plant or animal that grows, feeds, and is sheltered on or in another plant or animal, can be endo (within), ie ringworm, or ecto(outside), ie ticks
Term
prion
Definition
infectious agent composed only of protein, ie, madcow disease.; effect structure of brain or nervous tissue
Term
apoptosis
Definition
The preprogrammed death of a cell
Term
Gram negative vs gram positive
Definition
refers to whether or not a bacteria has an outer protective layer on the cell wall. Gram + has no outer membrane, Gram - has an outer membrane
Term
endo vs exo toxins
Definition
endo toxins are produced by gram negative bacteria, exo toxins are produced by gram positive bacteria, endoxins are considered pyrogenic because their release cause a fever
Term
virions
Definition
small particles of viruses
Term
Capsid
Definition
protein coat that surrounds a virus, may or may not have a surrounding envelope.
Term
Sickle cell anemia
Definition
shape of a cell that was adapted for malaria
Term
prodromium
Definition
The initial phase of illness when you first feel symptoms
Term
Interferon
Definition
protein released in response to a virus that tells other cells to put up a barrier to the virus.
Term
Hydrostatic pressure
Definition
the pressure exerted by a fluid because of its weight
Term
Oncotic pressure
Definition
the pressure exerted by the concentration of a particular solute
Term
Starling's hypothesis
Definition
Net filtration=forces favoring filtration-forces opposing filtration
Term
lymphedema
Definition
when the lymphatic pathways are blocked and the fluid is returned to the interstitial space
Term
pitting edema
Definition
when you push on edema and measure the depth and time of pit formation.
Term
chloride
Definition
major extracellular anion
Term
Normal level of sodium concentration in the body
Definition
135-145 mEq/L
Term
aldosterone
Definition
released in response to low sodium or high potassium, increases the reabsorption of sodium through distal tubules of the nephron, while ensuring potassium is secreted.
Term
action of renin
Definition
renin released in reponse to decreased blood flow, converts angiotensinogen to angiotensin I, AngioI converted to Angiotensin II in the lungs by ACE. AngioII causes release of aldosterone and ADH.
Term
Natriuetic peptides
Definition
hormones that control volume and sodium levels
Term
what are the four primary electrolytes in the body
Definition
magnesium, sodium, calcium, potassium
Term
two causes of sodium imbalances
Definition
Hyponatremia: low sodium, SS: lethargy, apathy, confusion, headache, seizures. Hypernatremia: high sodium SS: irritability, tremors, stupor, delirium, seizures, coma
Term
hyperkalemia
Definition
most often caused by the failure of the body to eliminate potassium. (renal failure) SS: vague muscle weakness, tetany, fatigue, n/d. dysrhythmias, bradycardia, peaked T waves, widening QRS
Term
Hypokalemia
Definition
caused often by diuretics,
Term
Normal levels for Potassium
Definition
3.5-5.0mEq/L
Term
normal levels for calcium
Definition
4.5-5.5mEq/L
Term
Causes for metabolic acidosis:
Definition
Acids: lactic acidosis, diabetic ketoacidosis, renal failure. Bases: diarrhea and vomiting
Term
Causes for metabolic alkalosis:
Definition
most commonly caused by excessive vomiting and long term diuretic use
Term
signs and symptoms of metabolic acidosis
Definition
indicative of or related to whatever is causing the acidosis
Term
S/S of metabolic alkalosis
Definition
non specific related to electrolyte imbalance
Term
Respiratory acidosis S/S
Definition
respiratory insufficiency, usually related to hypoxia
Term
Respiratory alkalosis S/S
Definition
paresthesia, circumoral numbness, chest tightness, dizziness, confusion, tetany
Term
incidence
Definition
the fraction of a population that contracts a disease in a given time frame
Term
prevalence
Definition
the fraction of a population that currently has a disease
Term
mortality
Definition
the number of people who have died in a given period
Term
Fick Principle
Definition
O2 available is proportional to the amount of hemoglobin, cardiac output and the ability of the pulmonary system to load the hemoglobin with oxygen
Term
Primary immune response
Definition
when the body forms antibodies in response to an antigen
Term
secondary immune response
Definition
the memory of the immune system, elevated levels of antibodies
Term
humoral mediated immunity
Definition
a result of the differentiation of lymphocytes into b cells, which are then activated by helper t cells
Term
cell mediated immunity
Definition
a resul of the differentiation of lymphocytes into T-cells
Term
haptens
Definition
little tiny protein molecules, for example pet dander, hay
Term
diapedesis
Definition
exudate squeezing through openings in endothelial walls
Term
immunogen
Definition
an antigen that initiates an immune response, foreign enough, heavy enough (100,000)
Term
what is the universal donor
Definition
O, has no antigens
Term
what is the universal recipient
Definition
AB, has both antigens
Term
plasmablasts
Definition
the functional unit of the humoral immune response
Term
what shape is a coccus bacteria
Definition
round
Term
what shape is a rod/baccilus bacteria
Definition
columnar
Term
what shape are spirrilum bacteria
Definition
spiral shaped
Term
which immunoglobin is the most prevalent in the body is responsible for memory formation
Definition
IgG
Term
Which immunoglobin is the biggest and first to respond
Definition
IgM
Term
Which immunoglobin is responsible for the allergic response
Definition
IgE
Term
What are the four stages of inflammatory response
Definition
acute inflammation, chronic inflammation, granuloma formation, healing
Term
Mast cells do two things, they are
Definition
degranulation, synthesis of chemical mediators
Term
what are the three things that stimulate degranulation
Definition
physical injury, chemical agents, immunological processes
Term
chemotaxis
Definition
the attraction of white blood cells
Term
margination
Definition
when phagocytes become sticky and adhere to the cell wall
Term
what is the order of the clotting cascade
Definition
factor x activated by thromboplastin-prothrombin-thrombin (clotting) - fibrinogen-fibrin
Term
bradykinin
Definition
performs the same function as the histamine response only slower
Term
saponification
Definition
fatty acids combine with electrolytes to form soap
Term
what are the three types of gangrenous necrosis
Definition
dry, wet, gaseous
Term
how does edema prevent nutrient transfer
Definition
It is a physical block
Term
What are two alternative names for the kreb cycle
Definition
tricarboxylic cycle, citric acid cycle
Term
hemolytic anemia
Definition
shock that results from the destruction of red blood cells
Term
shock
Definition
inadequate tissue perfusion
Term
preload
Definition
the amount of blood in the ventricles before contraction
Term
ischemic phase of shock
Definition
when the body contricts the capillaries, therefore stopping blood from going in or out, also called selective perfusion
Term
turgor
Definition
elasticity of the skin
Term
stagnant phase of shock
Definition
when the postcapillary sphincters are still shut and the precapillary sphincters open during decompensated shock
Term
Disseminated intravascular coagulation
Definition
when the clotting factors of the body are used up from stagnant RBC's and the body bleeds in many places
Term
washout phase
Definition
when the post capillary sphincters open as a result of metabolic acidosis, dumping potassium and acid into the blood
Term
Beck's triad
Definition
a classic s/s of cardiac tamponade: JVD, hypotension, muffled heart sounds
Term
exsanguination
Definition
when you have lost all of your blood volume
Term
res ipsa loquitor
Definition
an act is so obvious it speaks for itself
Term
gillion beret
Definition
virus that starts in the toes and moves upward
Term
Holman sign
Definition
DVT, causes pain in the calf
Term
thoracic outlet syndrome
Definition
caused by deceleration
Term
keloid
Definition
scar disorder that is very painful
Term
tacticle fremitus
Definition
vibrations felt when someone talks through touch
Term
helix
Definition
outer ring of cartilage around the ear
Term
hyphema
Definition
blood in the ocula
Term
purpura
Definition
blanching/purpling of the skin
Term
korotdoff sounds
Definition
blood rubbing against arterial walls
Term
addisons disease
Definition
adrenal insufficiency
Term
hirsutism
Definition
male pattern hair growth on the women folk
Term
borborygmus
Definition
hyperactivity of the bowel associated with gastroenteritis
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