Term
|
Definition
major component in many paints, laquers, glues, inks, cleaning liquids, metal degreasing, enamels, and dry cleaning |
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Term
|
Definition
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|
Term
What are the effects of inhaling butane, propane, or Freon? |
|
Definition
abnormal heart rhythms and the possibility of sudden death |
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Term
Family Rules for addressing addiction? |
|
Definition
serve to provide order, stability, consistency, and predictability. Restrict behavioral options.
-
Communication- to what extent, when, and how may family members communicate what they think and feel
-
Who can speak to whom in what fashion and about what?
-
Conventionalism- is one allowed to be different?
-
Values and spirituality
-
MORE_____
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|
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Term
|
Definition
- The addict's drug use is the most imporant thing in the family's life.
- The addict is not responsible for his or her behavior,and the drug isnot the cause of the family's problems.
- Status quo must be maintained at all times.
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|
Term
What are the common culprits in inhalant addiction? |
|
Definition
Industrial substances such as toulene, trichloroethylene, gasoline, butane, propane, and Freon |
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Term
|
Definition
Do we seek mates based on nuclear family dysfunction? We may look for people with weaknesses that accomodate our weaknesses. |
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|
Term
What is the effect of inhaling solvents? |
|
Definition
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|
Term
What are nitrites and what effect do they have for inhalers? |
|
Definition
- Nitroglycerin-based
- resultes in decreased BP, increased heart rate, sensations of warmth, euphoria, flushing, headache, enhanced orgasm
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Term
|
Definition
- secure attachment
- insecure attachment
- anxious/ambivalent
- disorganized
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Term
What are the six different ways that drugs can work on on neurotransmitters? |
|
Definition
1. Increasing the synthesis 2. Causing vesicles to leak 3. increasing release 4. decreasing reuptake 5. blocking the breakdown into inactive chemical 6. directly stimulating or blocking postsynaptic receptors |
|
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Term
|
Definition
The degree to which a drug perfers to bind to a particular receptor |
|
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Term
|
Definition
The tendency of a drug to activate the receptor |
|
|
Term
How do Koob and LeMoal (2001) conceptualize addiction? |
|
Definition
As a cycle of spiraling dysregulation of brain reward systems that progressively increases, resulting in the compulsive use and loss of control of drug taking. |
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Term
What drug has the largest medical and financial impact in the US? |
|
Definition
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|
Term
What is the most chemically addictive substance? |
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Definition
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|
Term
What types of drugs have shown the most increase over the past 5-10 years? |
|
Definition
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|
Term
What part of the brain is responsible for classical conditioning? |
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Definition
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|
Term
What is the function of the nucleus accumbens? |
|
Definition
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|
Term
What drug will cause the most significant neuro-trauma? |
|
Definition
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|
Term
|
Definition
1. nicotine 2. alcohol* 3. cannibis* 4. cocaine 5. amphetamine 6. LSD/Ecstasy/MDMA |
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|
Term
|
Definition
1. alcohol* 2. benzos 3. barbituates 4. cannibis* 5. opiates |
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|
Term
List the 3 GABA agonists. |
|
Definition
|
|
Term
|
Definition
alcohol cocaine amphetamine |
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|
Term
What are the receptor effects of cocaine> |
|
Definition
DA, 5HT, and NE agonist-block reuptake |
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|
Term
Describe the gender bias of substance abuse. |
|
Definition
SA is greater for makes but females experience greater physiological consequences in a shorter period of time. |
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|
Term
What is the projected cost of non-tobacco substance abuse yearly? |
|
Definition
|
|
Term
|
Definition
Nature appears to have stronger effect, particularly in males. |
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|
Term
Heritability is highest for___ |
|
Definition
cocaine or heroin addiction |
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|
Term
From where does the nucleus accumbens receive direct input? |
|
Definition
the ventraol tegmental area and the amygdala, hypothalamus, OFC, medial prefrontal cortex |
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|
Term
Where is the nucleus accumbens located? |
|
Definition
Rostral to the preoptic area of the hypothalamus, near septum, between the ventral portions of the caudate nucleus. |
|
|
Term
What does the nucleus accumbens do? |
|
Definition
mediates between the limbic structures(emotional) and striatum (motor response)
motivation toward objects and activities, avoiding danger, and seeking reward
important for placing value on environmental cues |
|
|
Term
Describe the Mesolimbic Dopaminergic Pathway (reward circuit) |
|
Definition
Ventral tegmental area--nucleus accumbens, prefrontal cortex, dorsal striatum |
|
|
Term
Decribe the Nigrostriatal Pathway |
|
Definition
substancia nigra--basal ganglia |
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|
Term
What is low 5HT associated with? |
|
Definition
depression and aggression |
|
|
Term
what is high 5HT associated with? |
|
Definition
psychotic symptoms and hallucinations |
|
|
Term
Identify the levels of SA treatment |
|
Definition
Level .5 IMPACT Level I Substance abuse (outpatient) Level II Intensive outpatient Level III Residential Level IV medical management (detox) |
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|
Term
Describe the DSM IV criteria for substance dependence |
|
Definition
3 in year
1. tolerance 2. withdrawal 3. consuming more of for longer period of time than intended 4. persistant desire or unsuccessful efforts to cutback 5. increased time spent acquiring substance or recovering from effects 6. giving up social, occupational, or recreational activities 7. continued use despite related physical or psychological problems |
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Term
What are the specifiers for Substance dependence according to the DSM IV |
|
Definition
with or without physiological dependence
Remission: Early (> 1 month) Sustained (> 1 year) Full (no use) Partial (continued use)
Environmental consideration |
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|
Term
Describe DSM IV criteria for substance abuse |
|
Definition
1 in year
1. failing in obligations 2. recurrent use in unsage situations 3. recurrent related legal problems 4. continued use despite social or interpersonal problems
NOT DEPENDENCE |
|
|
Term
What risk factors should be evaluated when considering substance abuse/dependence? |
|
Definition
Family history Gateway drugs Age of onset Blackouts Antisocial behavior Other Axis I or Axis II |
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|
Term
What contexual factors should be evaluated? |
|
Definition
Purpose Causality between use and problems Lifestyle Sabotaging original purpose? |
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|
Term
What are common comorbid conditions? |
|
Definition
Mood disorders Anxiety Disorders Personality Disorders ADHD Pain disorders |
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|
Term
How much of the variance does genetics account for in alcohol dependence? |
|
Definition
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|
Term
The disease model says alcohol dependence is ... |
|
Definition
genetic progressive fatal chronic |
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|
Term
Describe the Jellinick's phases of alcohol dependence |
|
Definition
Prodromal- Initial progression Increased tolerance; first blackout Increased sneaking, more blackouts, preoccupation, guilt, hurried ingestion
Crucial -impaired control; alibis, attempts to decrease guilt, aggression, unsuccessful attempts to quit, change in pattern of use, chemical-centered behavior, isolation, self-pity, geographic escape, resentment, family breakdown, medical care, morning use
Chronic_ - physical, emotional, and spiritual bankruptcy -prolonged binges and drug runs, protecting supply, lowering standards, decreased tolerance, withdrawal, compulsive use without euphoria, spiritual needs, rationalizationfails, admissiona and recovery |
|
|
Term
What is the overall heribililty of alcohol dependence? |
|
Definition
20-26% 30-36% in severe forms |
|
|
Term
what % if variance does environment account for in quantity, frequency, and density of drinking? |
|
Definition
|
|
Term
What is the heritability of alcohol dependence among treatment seeking women? |
|
Definition
|
|
Term
What are potential markers of alcohol dependence? |
|
Definition
aldehyde dehydrogenase (metabolizes alcohol in your system)
P3 event related potentials |
|
|
Term
What are alcohol and alcohol related conditions and their prevalence rates? |
|
Definition
Personality dx 15% Anxiety dx 11% Mood dx 9% alcohol dependence 4% drug dependence 1% |
|
|
Term
what has the greatest lifetime comorbidity among cannabis-dependents? |
|
Definition
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|
Term
What doubles the odds of experiencing a co-existing mood disorder? |
|
Definition
licit and illicit substance addiction together |
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|
Term
What % of adolescents with substance related disorder meet criteria for other disorders and what are the most common? |
|
Definition
60%; Conduct, ODD, Depression |
|
|
Term
What factors are included in the common factor model? |
|
Definition
genetic vulnerability antisocial PD DA dysfunction (mesolimbic pathway) poverty |
|
|
Term
What factors are involved in the multiformity model of comorbidity? |
|
Definition
heterogeneous, atypical forms of a disorder
degree of overlap among dxs (random) v more extreme forms of psych or SA disorder (extreme) |
|
|
Term
what factors are included in the 3 Independent Disorders model of comorbidity? |
|
Definition
comorbid condition is different than sole psychiatric or substance use DO |
|
|
Term
What factors are involved in the Causation/Reciprocal causation model of comorbidity? |
|
Definition
regardless of order of onset, do the separate DOs exacerbate one another? |
|
|
Term
What are features of dual diagnosis? |
|
Definition
antisocial features and supersensitivity to stress |
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|
Term
What has Clozapine been associated with? |
|
Definition
reductions in alcohol abuse |
|
|
Term
What are treatment considerations for dual diagnosis? |
|
Definition
integrated v sequential tx relationship v confrontation harm reduction v abstinence long-term, low intensity tx |
|
|
Term
What are objectives of SAMSHA? |
|
Definition
ID those with SA ASSESS full spectrum of problems PLAN appropriate interventions INVOLVE family and significant others EVALUATE effectiveness of interventions |
|
|
Term
What are dimensions related to level of care? |
|
Definition
Intoxication and withdrawal potential Biomedical conditions and complications emotional, behavioral, cognitive conditions and complications Readiness for change Relapse prevention Recovery environment |
|
|
Term
What contextual factors that SAMSHA evaluates? |
|
Definition
expectations for use internal triggers external triggers immediate reinforcers positive aspects of use negative aspects of use |
|
|
Term
Describe the CAGE screening criteria. |
|
Definition
need to Cut down? felt Annoyed with criticism of your drinking? felt Guilty about use? need an Eye-opener dose in the AM? |
|
|
Term
Describe the T-ACE screening criteria for pregnant women. |
|
Definition
Tolerance? Annoyed with criticism? need to Cut down? need an Eye opener? |
|
|
Term
Describe TWEAK screener for women. |
|
Definition
Tolerance? friends Worried? need an Eye opener dose in the AM? Amnesia? need to Kut down? |
|
|
Term
What are 3 quantity frequency questions? |
|
Definition
On average, how many DAYS/Wk do you drink alcohol?
How many drinks/day when you drink?
Max # drinks on any occassion in past month |
|
|
Term
Rapid Alcohol problems screen |
|
Definition
Do you sometimes take a drink in the morning when you first get up? During the past year, has a friend or family member ever told you about things you said or did while you were drinking that you could not remember? During the past year, have you failed to do what was normally expected of you because of drinking? During the past year, have you had a feeling of guilt or remorse after drinking? During the past year, have you lost friends or girlfriends or boyfriends because of drinking? |
|
|
Term
|
Definition
MAST/BMAST- (Brief) Michigan Alcoholism Screening Test: 25 and 10-item versions AUDIT- Alcohol Use Disorders Identification Test: 10-item screen. 3 on consumption; 7 on impact DAST/ DAST 10- Drug Abuse Screening Test. 10 and 20 item versions SASSI- Adolescent Substance Abuse Subtle Screening Inventory. Multiple versions |
|
|
Term
|
Definition
DAST 10 NIDA Modified ASSIST: NIDA Modified Alcohol, Smoking and Substance Use Involvement Screening (Comprehensive) CRAFFT Quiz: Designed for adolescents. 7- item SA screen. |
|
|
Term
Most common hallucinogens? |
|
Definition
LSD and mushrooms (psilocybin) |
|
|
Term
Effects of hallucinagens? |
|
Definition
Alter consciousness without excessive delirium, sedation, excitation, or cognitive impairment |
|
|
Term
How are hallucinagens typically adminstered? |
|
Definition
|
|
Term
Which processes are effected by hallucinagen intoxication? |
|
Definition
Somatic Perceptual Psychic Cognitive Autonomic |
|
|
Term
Health benefits of moderate ETOH use |
|
Definition
stress reduction protecive factor against coronary artery disease and cancer in men lower risk of cardiovascular disease in women |
|
|
Term
Women who drink an average of 3-9 drinks of ETOH weekly are at greater risk for ___? When does the risk reach 40% |
|
Definition
breast cancer; 1-2 drinks daily |
|
|
Term
Adolescents who abuse alcohol are more vulnerable to dysfunction in what areas of the brain when compared to adults? |
|
Definition
Frontal lobe and hippicampus |
|
|
Term
adolescents are more or less sensitive to the sedative effects of alcohol? |
|
Definition
|
|
Term
individuals who begin drink at what point have higher risk? |
|
Definition
|
|
Term
What are risk factors that are greater among women who abuse alcohol? |
|
Definition
breast cancer, hypertension, liver and pancreatic damage, cognitive dysfunction |
|
|
Term
What is the difference in BAC for women compared to men of similar weight and what are some reasons women obtain higher BAC? |
|
Definition
25-30% higher BAC different lipid distribution less ADH than men, less metabolization birth control pils slow down elimination of etoh |
|
|
Term
What is the only form on alcohol that can be comsumed without being toxic? |
|
Definition
|
|
Term
What is the ethanol content of common drinks? |
|
Definition
beer 3-7% wine 8-14% fortified wine 17-22% liquor 40%+ |
|
|
Term
____ of etoh ingested is absorved through the stomach; ___ in the instestines. |
|
Definition
|
|
Term
what is the most powerful influence on absorption? |
|
Definition
the presence of absence of food in the stomach |
|
|
Term
As concentration of etoh _____, absorption ______ and BAC _______. |
|
Definition
increases, increases, increases |
|
|
Term
How does alcohol distributed thoughout the body impact absorption? |
|
Definition
the more muscle and fat to absorb etoh, the slower the increase in BAC but the longer it remains in the tissues before elimination.
etoh passes freely from mother to fetus and fetus may achieve higher BAC |
|
|
Term
etoh passes freely from mother to fetus and fetus may achieve higher or lower BAC? |
|
Definition
|
|
Term
How much of etoh is metabolized prior to excretion? |
|
Definition
|
|
Term
How much of etoh is eliminated unchanged through the lungs or urine? |
|
Definition
|
|
Term
Where is most alcohol metabolized? |
|
Definition
|
|
Term
|
Definition
alcohol dehydrogenase (ADH) breaks it down into acetaldehyde which is broken down into acetate which is excreted. |
|
|
Term
What happens when acetaldehyde does not repidly metabolize? |
|
Definition
It becomes toxic and causes acute nausea |
|
|
Term
|
Definition
It cause acetaldehyde to accumulate with consumption of etoh causing nausea |
|
|
Term
The rate of etoh metabolize is ______ |
|
Definition
|
|
Term
1 oz whiskey is metabolized in _____ |
|
Definition
|
|
Term
BAC does not rise significantly unless more than _____ drink is consumed per _______ |
|
Definition
|
|
Term
How does metabolism of etoh effect other drugs? |
|
Definition
It increases enzymes to metabolize etoh which also metabolize other drugs making them less effective or more toxic |
|
|
Term
|
Definition
metabolic tolerance to etoh causes tolerance to other drugs |
|
|
Term
How is a person effected with a BAC of up to .10 (4oz/hr)? |
|
Definition
positve subjective effects may impact judgment, fine motor coordination, reaction time |
|
|
Term
How is a person effected with a BAC between .10-.30 (48oz/hr)? |
|
Definition
decreased motor coordination and reflexes staggering slurred speech |
|
|
Term
How is a person effected with a BAC between .30-.40 (192oz/hr)? |
|
Definition
impaired voluntary response stimulation hyper or hypothermia anesthesia |
|
|
Term
How is a person effected with a BAC between .40-.60 (384oz/hr)? |
|
Definition
impaired sensation, movement, and self-protective reflexes
comatose |
|
|
Term
How is a person effected with a BAC above .60(1020 oz/hr)? |
|
Definition
decreased breathing and cardiac function death |
|
|
Term
genetic risk for alcohol dependence is greater for men or women? |
|
Definition
|
|
Term
males of __% risk of alcohol dependence in their lifetime v __% risk for women. |
|
Definition
|
|
Term
What is the difference between Type I and Type II alcoholism? |
|
Definition
Type II is less common, occurs only in men, and is characterized by adolescent onset, aggression, legal problems, and use of other drugs |
|
|
Term
|
Definition
impact of alcohol on brain wherewith only some cell groups are stimulated with low doses but the firing rate decreases with increased consumption.
It may also produce inhibitory neurons that provide a net effect of stimulation at lower doses. |
|
|
Term
etoh _____ the ______ effect of GABA receptors and ________ the _______ effect of glutamate receptors. |
|
Definition
increases, inhibitory decreases, excitatory |
|
|
Term
How does suppression of glutamate activity effect the brain? |
|
Definition
It inhibits NMDA receptors which are important for forming new memories (blackouts) |
|
|
Term
What % of college students endorse a history of blackouts? |
|
Definition
|
|
Term
What is one explanation for blackouts? |
|
Definition
etoh suppresses glutamate activity inhibiting NMDA receptors which are important for forming new memories. |
|
|
Term
Acute effects of alcohol use and their causes? |
|
Definition
hangovers- etoh effect on blood vessels and fluid
GI upset- toxic by-products of etoh elimination and irritation to stomach
hippocampal neuronla loss among binging adolescent animals |
|
|
Term
What are chronic alcohol effects? |
|
Definition
dysfunctions of the brain,liver, and digestive system. Skin, peripheral neuropathy, endrocrine, and hypertension conditions, FAS |
|
|
Term
What are some medical diagnostics to assess alcohol abuse? |
|
Definition
Liver function tests Mean corpuscular volume blood pressure physical exam (MSE, neuro, liver palpitation) abdominal sonogram |
|
|
Term
What are regions of the brain that are vulnerable to alcohol abuse? |
|
Definition
frontal lobe- exectutive functioning hippocampus- memory cerebellum- wide based gait mammillary bodies- beneath hypothalamus. lesions consistent with nutritional deficit and Korsakoff's syndrome |
|
|
Term
What are some neuroimaging correlates with alcohol dependence? |
|
Definition
increased ventricle size white matter disease atrophy in frontal, temporal, parietal lobes and cerebellum
**covaries with age |
|
|
Term
How many drinks per day are associated with moderate deficits equivalent to alcohol dependent persons? |
|
Definition
|
|
Term
How long does it take cognitive deficits to resolve? |
|
Definition
|
|
Term
Cognitive functioning is related more to ___ than ____ history of drinking. |
|
Definition
|
|
Term
Adolescents are more affected by ____ drinking but older adults with long drinking history have more significant ____ and _____ |
|
Definition
binge; cognitive deficits and medical complications |
|
|
Term
What % of long term alcohol abusing men report reduced libido? |
|
Definition
|
|
Term
What are sexual affects of long term alcohol abuse in men? |
|
Definition
erectile dysfunction decreased sperm count decreased semen production feminization in extreme cases testicular atrophy |
|
|
Term
|
Definition
used in making rope, cloth, paper |
|
|
Term
|
Definition
cultivated for psychoactive properties |
|
|
Term
Where is highest THC content found in plant? |
|
Definition
in the resinated flower tops or buds; not leaves |
|
|
Term
How is the marijuana drug formed? |
|
Definition
at maturation, cannabidiolic acid (CBDA) is converted to cannabidiol (CBD) then to THC and finally cannabinoid |
|
|
Term
What determines potency of MJ? |
|
Definition
the extent to which CBD is converted to THC. THe higher the rate of THC to CBD and CBN, the greater the pure drug effect |
|
|
Term
What happens when MJ plant is harvested beyond peak THC ratio |
|
Definition
it has a more sedating effect |
|
|
Term
How has the potency of MJ changed over the last 40 years? |
|
Definition
|
|
Term
What is Low-grade content MJ? |
|
Definition
1-3% THC. mixture of leaves and stems |
|
|
Term
What is High grade content MJ? |
|
Definition
female plans. fertilized plants typically have 7-8% THC. Unfertilized plants do not produce seeds and are the most potent (7-20% (hashish) ) |
|
|
Term
What drug has highest THC content? |
|
Definition
|
|
Term
More THC is absorbed through ____ smoking than _____ smoking. |
|
Definition
|
|
Term
THC absorption is slower when THC products are ____ |
|
Definition
|
|
Term
THC is rapidly absorbed by blood in the ___ |
|
Definition
|
|
Term
_____ of THC is still present in the blood ___ hours after smoking |
|
Definition
|
|
Term
___% of THC and its metabolites may remain in teh body a full ___ after smotking. |
|
Definition
|
|
Term
Where are cannabinoid receptors concentrated? |
|
Definition
In the hippocampus and less so in the cerebellum and basal ganglia |
|
|
Term
How does MJ effect memory? |
|
Definition
It may suppress activity of hippocampal cells and hinder acquisition of new memories |
|
|
Term
THC disrupts memory far more in adolescents or adults? |
|
Definition
|
|
Term
What are subjective effects of THC intoxication? |
|
Definition
relaxation mood elevation sedation stimulation silliness sensory enhancement contemplative silence |
|
|
Term
What are cognitive effects of THC intoxication? |
|
Definition
diminished memory while drug is still active altered sense of time/altered attention decreased problem solving/mental flexibilty in chronic users paranoid ideation (contextual)
*long-term effects may be age dependent but more dependent on age of onset |
|
|
Term
What are behavioral effects of THC intoxication? |
|
Definition
hunger decreased aggression amotivation impaired concentration and driving correction
*earlier use = higher risk for psyc sxs later |
|
|
Term
What are some physiological effects of THC intoxication? |
|
Definition
increased heart rate decreased sperm count, erectile dysfunction, increased prolactin irregular mensus |
|
|
Term
What are some effects MJ use may have on other parts of the body? |
|
Definition
may decrease immunological functioning chronic bronchitis lung cancer (esp with tobacco use) |
|
|
Term
Why are MJ smokers at risk for developing lung cancer? |
|
Definition
they inhale less smoke but higher levels of CO and tar |
|
|
Term
What % of MJ users develop dependency? |
|
Definition
|
|
Term
What are acute presentations of inhalant abuse? |
|
Definition
cardiac DO hypoxia/anoxia ataxia encephalopathy neuropathy metabolic DO degenerative DO demyelinating DO nutritional DO |
|
|
Term
What are chronic problems related to inhalant abuse? |
|
Definition
brain, liver, renal, and adrenal toxicity neuropathies cardiac problems blood DO muscle weakness movement DO embryonic DO respiratory problems |
|
|
Term
What are common high efficacy opiates? |
|
Definition
Morphine Dilaudid Demerol Fentanyl |
|
|
Term
When are high efficacy opiates prescribed? |
|
Definition
surgery of palliative care |
|
|
Term
What are common medium efficacy opiates? |
|
Definition
Vicodin Oxycontin Percocet Darvocet |
|
|
Term
What are common low efficacy opiates? |
|
Definition
codeine lomotil (diarrhea) |
|
|
Term
|
Definition
cite of neurotransmitter action for opiates. affect pain and breathing. CNS and GI tract |
|
|
Term
|
Definition
Mu Delta Kappa (no euphoria) |
|
|
Term
What are drug effects of ecstasy? |
|
Definition
enhanced somatosensation, stimulation, interpersonal satisfaction, empathy and decreased aggression |
|
|
Term
What are risks of ecstasy use? |
|
Definition
risks are secondary to deydration and hyperthermia
cardic complications
seizures
5HT suppression
depression and memory dysfunction |
|
|
Term
For what are amphetamines prescribed? |
|
Definition
narcolepsy, ADHD, weight loss, performance enhancement, chronic fatigue, depression |
|
|
Term
How do amphetamines work in the brain? |
|
Definition
They stimulate release of NE, DA and 5HT |
|
|
Term
WHere is cocaine metabolized? |
|
Definition
|
|
Term
What are some frequently prescribed hypnotics? |
|
Definition
|
|
Term
What % of US population abuse substances? |
|
Definition
|
|
Term
What % of ppl are effected bu SA in US? |
|
Definition
|
|
Term
What % children are exposed to etoh abuse or dependence? |
|
Definition
|
|
Term
How many 12yo+ dependent in US? |
|
Definition
|
|
Term
Describe categories of family boundaries. |
|
Definition
diffuse/enmeshed clear rigid disengaged |
|
|
Term
What are the 8 dynamics of addiction according to Platinga? |
|
Definition
1. Repetitive habit forming behavior 2. negative effects 3. vow to stop 4. attempt to relieve distress with more addictive behavior 5. deterioration of relationships 6. obsession 7. compulsion 8. pulling others into web |
|
|