Term
| what is the diff b/t substance abuse and addiction |
|
Definition
subs. abuse is a social judgement placed on the drug (illegal drugs)
Addiction is a feeling that MUST be continually administered |
|
|
Term
| diff b/t addiction and physical depend. |
|
Definition
addiction- perception of satisfaction
phys dependence- neurobiological adaptation w/intense withdrawal symptoms |
|
|
Term
| Where is dopamine synthesized and released to? |
|
Definition
ventral tegmental area
nucleu accumbens and prefrontal cortex |
|
|
Term
| Final common pathway for drug seekers |
|
Definition
| prefrontal-->nuc. accumbens-->ventral pallidium |
|
|
Term
| what is the major active chemical in marijuana |
|
Definition
|
|
Term
| THC does what to reward system |
|
Definition
| activates it by increasing dopa release |
|
|
Term
| Where are cannabinoid receptors located? |
|
Definition
area of memory
perception
fine motor coordination
pain sensation |
|
|
Term
|
Definition
| enhance synaptic activity of biological amines (nor ep, dopa, and ser) |
|
|
Term
| Chronic use of meth leads to |
|
Definition
|
|
Term
|
Definition
increase wakefulness
increased phys activity
decreased appetite
euphoria |
|
|
Term
| Alcohol severely affects this receptor |
|
Definition
NMDA- responsible for cell growth, memory and seizure threshold.
135% ethanol inhibits receptors
alcohol-cerebral cortex |
|
|
Term
| Ethanol withdrawal can cause |
|
Definition
|
|
Term
| alcohol causes brain infarctions how? |
|
Definition
occlusion of cerebral arterioles and capillaries
Also big change in blood platelet adhesion |
|
|
Term
|
Definition
31% impaired judgement
62 legally impaired
124 Under influence
186 near comatose |
|
|
Term
| 3 hallmarks of chronic alcohol |
|
Definition
alcoholism
tolerance
physical dependence |
|
|
Term
| Wernicke's encephalopathy |
|
Definition
degenerative disease
brown mammillary bodies
mental confusion |
|
|
Term
|
Definition
severe memory loss
lesion in dorsomedial nucleus of thalamus |
|
|
Term
| Alcoholic Cerebellar degeneration |
|
Definition
ataxia of gait
atrophy of cerebellum |
|
|
Term
| This pathway is vulnerable to Ecstacy |
|
Definition
| Serotonin in cerebral cortex |
|
|
Term
| adverse effects of ecstacy |
|
Definition
clouded thinking
hyperthermia
disturbed behavior
jaw clenching |
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