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Stroke
Lecture 6
34
Medical
Graduate
04/05/2011

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Cards

Term
CVA vs. TIA
Definition
CVA: sudden onset, rapidly progressing, lasts >24h; permanent damage
TIA: sudden onset, rapidly progressing, lasts <24h; symptoms resolve
Term
most common cause of infarction
Definition
atherothrombotic
Term
most common cause of stroke
Definition
infarction
Term
most common cause of intraparenchymal hemorrhage
Definition
hypertension
Term
most common cause of subarachnoid hemorrhage
Definition
ruptured aneurysm
Term
most common location for ruptured and non-ruptured aneurysms
Definition
ruptured - ACA; non-ruptured - MCA
Term
CADASIL stands for...
Definition
cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
Term
CAA stands for __ and is a cause of __ hemorrhage
Definition
cerebral amyloid angiopathy; intraparenchymal hemorrhage
Term
contralateral hemiplegia is caused by an infarction of the [MCA/ACA/PCA]
Definition
MCA
Term
distal contralateral leg weakness and sensory loss is caused by an infarction of the [MCA/ACA/PCA]
Definition
ACA
Term
contralateral homonymous hemianopsia is caused by an infarction in the [MCA/ACA/PCA]
Definition
PCA
Term
Gerstman syndrome is caused by an infarction in the...
Definition
angular gyrus
Term
agraphia, acalculia, finger agnosia, right to left confusion
Definition
Gerstmann syndrome
Term
occlusion of vertebral a. causes...
Definition
Wallenberg syndrome
Term
damage of spinal tract of trigeminal nerve affects...
Definition
ipsilateral pain and temp sensation on face and corneal reflex
Term
damage of anterolateral spinothalamic tract affects...
Definition
contralateral pain and temp sensation of limbs and trunk
Term
ipsilateral paralysis of soft palate, pharynx and larynx is caused by...
Definition
lesion in nucleus ambiguus
Term
gross and histological changes in infarction at 24h, 3d, 1wk, 2wk, and months
Definition

1-2d: pallor, red neurons

3-4d: maximal edema, risk of herniation, macrophages; cracking

5-7d: macrophages, astrocytosis, cysts; crumbling

>2 wk: liquefaction, macrophages

months: cysts, astrocytosis, macrophages; intact subpial rim

Term
tx for stroke
Definition
TPA, ASA within 3h; stent in 3-12h
Term
sources of embolic infarction
Definition
mural thrombus/valves, carotid plaque, aorta
Term
lacunar infarcts usually occur with __ hemorrhages
Definition
hypertensive hemorrhage
Term
lipohyalaniosis, hyalin sclerosis, fibrinoid necrosis, microemboli, microatherosclerosis
Definition
lacunar infarcts
Term
Binswanger's disease
Definition
medium size vessel; subcortical arteriosclerotic leukoencephalopathy; hypoperfusion of periventricular white matter
Term
HTN hemorrhage usually affects what parts of the brain?
Definition
basal ganglia, thalamus, pons, cerebellum
Term
CAA pathology
Definition
elderly pt with lobar hemorrhage and amyloid deposition
Term
AVM does not rupture -->
AVM ruptures -->
Definition
no rupture -> epilepsy; rupture -> hemorrhage
Term
AVM age range
Definition
20 year olds
Term
which tumor has highest risk of causing hemorrhage?
Definition
oligodendroglioma
Term
what tumor most commonly causes hemorrhage?
Definition
GBM
Term
saccular aneurysm age range
Definition
40-60yo
Term
headache + meningeal signs; ddx?
Definition
subarachnoid hemorrhage, meningitis with mass lesion
Term
risk factors for aneurysm formation
Definition
HTN, hypoplasia, ADPKD, collagen diseases, connective tissue diseases, AVM, elevated CAs
Term
histologically, aneurysm is made up of...
Definition
adventitia and intima only
Term
effects of global ischemic encephalopathy
Definition
respiratory brain, laminar cortical necrosis (3, 5, 6), "no flow" phenomenon, red neurons
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