Term
| classification of streptococci is done by looking at |
|
Definition
hemolytic pattern
alpha: producing hydrogen peroxide
none (gamma)
beta: completely lysing blood cell |
|
|
Term
beta hemolytic pattern is further classified into__
based on __ |
|
Definition
Lancefield groups
group-sepcific carbohydrate
this binds to specific antigen on bacteria surface |
|
|
Term
| lancefield grop A represntative species is/are |
|
Definition
|
|
Term
lancefield group A s. pyogenes
localized infections include |
|
Definition
pharyngitis "strep throat"
impetigo (superficial skin infection)
cellulitis/ erysipelas (deeper skin infection)
skin/soft tissue infection
scarlet fever rash
|
|
|
Term
lancefield group A s. pyogenes
invasice infections include |
|
Definition
necrotizing fasciitis
"flesh-eating infections"
bacteremia
steptococcal toxic chock syndrome
|
|
|
Term
| symptoms of s. pyogenes incfections are/is |
|
Definition
asymptomatic colonization is common
in respitory tract, nouth, skin |
|
|
Term
| risk group for s. pyogenes: |
|
Definition
|
|
Term
| transmission method for s. pyogenes |
|
Definition
| vis droplets in a shared environment |
|
|
Term
| major virulent factor of steptococci |
|
Definition
M protein
(anti-phagocytic) |
|
|
Term
| what is the function of capsule in s. pyogenes? |
|
Definition
virulent factor
protects against complement-mediated phagocytic killing |
|
|
Term
one of the hemolysins
family of large, growing toxins
cholesterol-dependent
pore forming
oxygen-labile hemolysin |
|
Definition
|
|
Term
| upon cholesterol binding, pore is formed by ___ |
|
Definition
|
|
Term
one of the Hemolysins
oxygen-sable hemolysin (responsible for beta-hemolysis)
non-immunogenic
|
|
Definition
|
|
Term
|
Definition
streptolysin O
streptolysin S |
|
|
Term
| superanigens involved in scarlet fever rash |
|
Definition
SpeA and C
tjey are pyrogenic exotoxins (erythrogenic toxins)
toxic activation of immune system! |
|
|
Term
|
Definition
colonization
local infection/invasion
dissemination/invasive disease
|
|
|
Term
| major virulent factors that is involved in pathogenesis are |
|
Definition
Hyaluronic acid capsule (anti-phagocytic)
SLO (resist ingestion during colonization)
M protein (anti-phagocytic) |
|
|
Term
|
Definition
rapid strep antigen detection test : detects group A carbohydrate
only 75% sensitive
culture on blood agar (beta hemolytic colonies) |
|
|
Term
|
Definition
|
|
Term
| any vaccines for s. pyogenes? |
|
Definition
|
|
Term
| hemolytic pattetn for s. pneumoniae |
|
Definition
alpha-hemolytic
(no streptococcal antigen) |
|
|
Term
| charactristics of s. pneumoniae |
|
Definition
gram positive, alpha-hemolytic
bile sensitive
opotochin-sensitive
diplococcus |
|
|
Term
| symptoms of s. pneumoniae |
|
Definition
asymptomatic carrier/colonization
|
|
|
Term
| localized infection of s. pneumoniae |
|
Definition
pneumonia (mostly elderly)
otitis media (mostly children) |
|
|
Term
| invasive infection of s. pneumoniae |
|
Definition
bacteremia/ sepsis
meningitis |
|
|
Term
| transmission of s. pneumoniae |
|
Definition
via droplet
exclussively human pathogen
|
|
|
Term
| leading vaccin-preventable killer of children |
|
Definition
| invasive pneumococcal disease |
|
|
Term
| diagnosis of pneumonia is popularly done by |
|
Definition
|
|
Term
| other diagnostic methods? |
|
Definition
microscopy from source (gram+ cocci)
bile sensitive and optochin sensitive |
|
|
Term
| treatment for s. pneumoniae? |
|
Definition
penicillin
(antibiotic resistance rising) |
|
|
Term
| are there vaccines for s. pneumoniae? |
|
Definition
yes
prevnar, polysacchride conjugate vaccins (2000) |
|
|
Term
| group B representative species |
|
Definition
|
|
Term
| s. agalactiae infections include |
|
Definition
neonatal pneumonia
sepsis |
|
|
Term
| virulence factors for s. agalactiae |
|
Definition
| capsule, beta-hemolysin, adhesin, Cda peptidase |
|
|
Term
| s. mutans, mitis, salvivarius, thermophilus, sanguinis are |
|
Definition
virudans group
(no antigen) |
|
|
Term
| viridans streptococcus infections include |
|
Definition
|
|
Term
| diagnosis of viridans streptococcus |
|
Definition
alpha-hemolytic
optichin-resistant
bile-resistant |
|
|
Term
|
Definition
|
|
