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Steps of Adrenergic Fxn
adrenergic neurotransmission
6
Medical
Graduate
08/27/2013
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Term

synthesis

 

 Definition

1. tyrosine enters

2. tyrosine hydroxylase converts it to DOPA

2. DOPA metabolized to DA (dopamine)
Term
storage in vesicles
 Definition

1. vesicle monamine transporter (VMAT) puts half of DA into storage vesicles

2. dopamine B-hydroxylase turns DA into NE

[3. EPI releasing cells also contain phenylethanolamine-N-methyltransferase to convert NE to EPI]
Term
release of catecholamines
 Definition

1. voltage dependant opening of Ca channels elevates intracellular Ca 

2. stimulates interaction of SNARE proteins to enable vesicle fusion with membrane and exocytosis
Term
binding of NT to post-syn or pre-syn sites
 Definition
NTs bind to rec's. Action of NT depends on the rec type, second messenger system, and machinery of cell type
Term
Termination of action
 Definition

1. reuptake

2. diffusion

3. metabolic transformation

    - MOA (monoamine oxidase)

    - COMT (catechol-o-methyltransferase) 

       
Term
whole shebang
 Definition

1. tyrosine-->DOPA (tyrosine hydroxylase)

2. DOPA-->DA

3. DA inside vesicle (VMAT)

4. DA-->NE (dopamine B-hydroxylase)

[5. NE-->EPI (phenylethanolamine-N-methyltransferase)]

6. volt gated Ca channels-->inc iCa++

7. activation of SNAREs

8. NT release/binding

9. termination

     a) re-uptake

     b) diffusion

     c) metabolism (MAO, COMT)
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