Term
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Definition
| unspecialized cells capable of renewing them-selves through cell division after long period of inactivity |
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Term
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Definition
| under certain physiologic or experimental conditions they can be induced to become tissue-or-organ-specific cells with special functions |
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Term
| embryonic stem cells (ES) |
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Definition
| derived from pre-implantation or peri-implantation embryos; PLURIpotent, self-renew in culture, differentiate into ectoderm, mesoderm and endoderm cells in vivo |
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Term
| Hematopoetic stem cells (HSCs) |
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Definition
| self-renew in bone marrow and produce entire blood system |
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Term
| "stemness" characteristics |
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Definition
| sense a broad range of growth factors and signaling molecules, express genes that are involved in regulating cell cycle and quiescence, can express downstream signaling components to respond to these signals |
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Term
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Definition
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Term
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Definition
| ability of a single cell to divide and produce all the differentiated cells in an organism including extra-embryonic tissues |
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Term
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Definition
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Term
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Definition
| stem cell that has the potential to differentiate into any of the three germ layers (endoderm, mesoderm, ectoderm) |
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Term
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Definition
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Term
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Definition
| have the potential to give rise to cells from multiple lineages |
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Term
| hematopoietic progenitors |
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Definition
| also called colony forming units that have limited self-renewal and differentiation; unipotent (CFU-E) and oligopotent (CFU-GM) |
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Term
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Definition
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Term
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Definition
| different host and recipient, requires a matched donor can have severe side effects (GVHD and transplant rejection) |
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Term
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Definition
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Term
| imperfect markers for human HSCs |
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Definition
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Term
| enritchment of human HSCs (cannot purify) |
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Definition
| CD34 antibody-based magnetic enritchment |
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