Term
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Definition
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Term
| Microscopic Morphorlogical Appearance of Staphlococcus |
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Definition
gram positive cocci
non-spore formers (can survive in relatively harsh condition)
non-motile
usually no capsule (aureus has capsule) |
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Term
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Definition
virulence factor- protein toxin
lyse RBC cells by disrupting cell membrane |
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Term
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Definition
virulence factor-protein toxin
lyses white blood cells by disrupting cell membrane |
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Term
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Definition
virulence factor- protein toxin
food poisoning |
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Term
| Toxic shock syndrome (TSST-1) |
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Definition
virulence factor- protein toxin
stimulates production of interleukin (IL-1) by macrophages resulting in fever induction |
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Term
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Definition
virulence factor - enzymes
plasma clotting protein; converts fibrinogen to fibrin
-coats bacteria with fibrin and prevents phagocytosis
-aids in attachment |
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Term
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Definition
virulence factor - enzymes
digests fibrinogen (fibrin clots) |
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Term
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Definition
virulence factor - enzyme
"spreading factor"
digests hyaluronic acid round host cells: promotes invation |
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Term
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Definition
virulence factor - enzyme
degrades lipids: allows bacteria to colonize oily skin
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Term
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Definition
virulence factor - enzyme
hydrolyzes penicillin; drug resistance
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Term
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Definition
virulence factor - enzyme
degrades H2O2; a toxic metabolic end product
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Term
exfoliatin
or
epidermolytoc toxin |
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Definition
virulence factor - enzyme
protease that causes peeling of superficial skin layers by dissolving intracellular bridges
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Term
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Definition
virulence factor- structural surface component
surface component linked to peptidoglycan layer of cell wall;
inhibits antibody-mediated clearance of bacteria by binding to IgG (non competitively binds-> decreases antibody immunity) |
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Term
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Definition
virulence factor- structural surface component
binds to tissue components; cell adhesion |
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Term
staphylococcus aureus
carriage location?
carriage rate? |
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Definition
major pathogen of genus staphylococcus
anterior noses, nasopharynx and skin
30-50% of healthy adults |
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Term
virulence factors/ species identification of
staphylococcus aureus |
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Definition
coagulase positive
hemolysin
leukocidin
protein A
capsule |
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Term
| toxins of staphylococcus aureus |
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Definition
hemolysin, leukodin
enterotoxin
exfoliatin or epidermolytic toxin |
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Term
| superficial infections caused by staphylococcus aureus |
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Definition
| localized cutaneous infections |
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Term
| toxigenic infections of staphylococcus aureus |
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Definition
staphylococcal scalded skin syndrome SSSS
(by exfolatin)
toxic shock syndrome TSTT-1
gastrointestinal disease (by enterotoxin) |
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Term
superficial cutaneous infections
symptoms, pathogenesis
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Definition
pyodermic infection
systemic infections
pimples, boils, carbuncles and impetigo
symptom: pus formation, staphylococcus,
pyogenic cocci |
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Term
| staphylococci invades skin at |
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Definition
sebaceous gland opening
hair folicle
wound |
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Term
| primary infection sites for steph. aureus |
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Definition
| faces, back of neck, buttocks |
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Term
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Definition
| edema, erythema, pain, pus |
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Term
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Definition
| elderly and young children with poor hygiene |
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Term
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Definition
exfolatin or epidermolytic toxin
spreads epidermal layer from the dermis, blistering and peeling of the skin, exposed red under layer
looks like burned skin |
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Term
mode of infection of SSSS
(how it starts, how it progresses) |
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Definition
syndrome begins as an erythema around the mouth and nose
spreads rapidly to infect skin of the neck, trunk and extremities |
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Term
|
Definition
infants, young children <4 yr
neonatal infection |
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Term
| primary infected sites of SSSS |
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Definition
umbilical cord and eyes
low mortality rate |
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Term
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Definition
| secondary infection of the denuded skin by other bacterial pathogens |
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Term
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Definition
| topical antibiotic- mupirocin |
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Term
| incidence of infection of Toxic Shock Syndrome |
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Definition
| usage of super absorbent vaginal tampons that was cellulose based |
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Term
| virulent feature of Toxic Shock Syndrome |
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Definition
toxic shock syndrome toxin
TSST-1 |
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Term
| mode of infection of Toxic Shock Syndrome |
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Definition
super absorbant brands strongly bind to Mg++ ions
low concentration of Mg++ triggers TSST-1 production which is absorbed into the bloodstream
TSST-1 that stimulates T-lymphocytes to produce cytokines intravascularly resulting in endothelial cell damage-shock and multi-system organ failure |
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Term
| 10 days later of Toxic Shock Syndrome |
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Definition
hands and soles of feet develop a sunburn-like rash which results in a peeling of the skin
"strawberry tongue" |
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Term
| severe symptoms of Toxic Shock Syndrome |
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Definition
| shock and multi-organ failure |
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Term
| death rate of Toxic Shock Syndrome |
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Definition
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Term
| source contamination of food poisoning |
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Definition
| staphylococcal lesions of skin contaminates food then food is left unrefrigerated, room temperature grows s. aureus--> production of enterotoxin |
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Term
| virulence factor of food poisoning |
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Definition
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Term
| coagulase negative staphlococcus |
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Definition
s. epidermis
s. saprophyticus |
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Term
| route of infection of coagulase negative s.epidermis |
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Definition
surgical procedures that involve the insertion of foreign bodies- heart, catheter, etc
attachment of bacteria to foreign body |
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Term
| infections of s. epidermis |
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Definition
| endocarditis, urinary tract infection, wound infection |
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Term
| bacterial sensitivity or resistance to antibiotic |
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Definition
novobiocin
s.epidermis: sensitive (no growth)
s. saphrophyticus: resistant (growth)
under novobiocin disk |
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Term
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Definition
MASA
methicillin resistant s.aureus |
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