Term
|
Definition
usually catalase positive
mostly reside on skin and mucosa |
|
|
Term
|
Definition
found in nasal passages of around 50% of population
reproductive tracts of women
can cause mild skin infections to sepsis
growth on most media, anaerobic/aerobic |
|
|
Term
|
Definition
resistant to most beta lactam antibiotics - methicillin
has PBP2A - penicillin binding protein - binds to rings not allowing antibiotic binding
5% of population w S.aureus are asymptomatic carriers
systemic - spesis-bacteraemia-minigitis
bone/joint - septic arthritis
pneumonia
skin/soft tissue - impetigo,cellulitis,necrotising facilitis
treatment:
-clindamycin
-tetracycline |
|
|
Term
| S.aureus virulence factors |
|
Definition
enzymes - secreted
exotoxins - secreted
invasins - secreted
adhesins - membrane bound |
|
|
Term
|
Definition
protein a - binds protein
fibronectin binding proteins
collagen binding proteins
capsular polysaccharides |
|
|
Term
|
Definition
super antigens
-staph exotoxins (ETs)
-TSST1
cytolytic toxins
-produce pores
Leukocidins
-PVL |
|
|
Term
|
Definition
Panton valentine leukocidin
2 protein subunits that produce pores
targets WBC, macrophages, monocytes
only in 5% of sa isolates |
|
|
Term
|
Definition
lipases
nucleases
proteases
coagulase |
|
|
Term
|
Definition
slow growing morphological variants
in persistant and relapsing infections
auxotrophic - produces the organic metabolites it needs to grow |
|
|
Term
|
Definition
encourages clotting in host
fibrin coated sa more resistant to phagocytosis |
|
|
Term
|
Definition
swabs from multiple body regions
selective chromogenic agar
all inpatients screened and carriers are treated with antimicrobial bath |
|
|
Term
|
Definition
staph or strep associated
bodies reaction to toxin send it into shock
life threatening
starts with flu like symptoms + nausea
proresses to high fever, hypotension, organ failure
50% associated with tampon usage
50% -soft tissue infection/ post reparatory viral pneumonia |
|
|
Term
|
Definition
supportive measures
targeted antibody therapy
requires ICU
5-20% mortality |
|
|
Term
|
Definition
staphylococcal scalded skin syndrome
wide spread blister type of impetigo
painful blisters
can spread systemically
can effect immunocompromised individuals
blistering produced by exfoliative toxin a and b |
|
|
Term
|
Definition
irritability/poor feeding
not wanting to be held
patchy painful rash
fever
large fragile blisters
sloughing of skin
large areas of exposed and raw skin |
|
|
Term
|
Definition
ETA & ETB
5% of sa strains
ETA encoded on chromosomes
ETB encoded on plasmid
proteases attack DMG1
DMG1= keratinocyte involved in cell to cell attachment
levels of DMG1 decrease with age explaining the prevalence in children
toxins produced in exponential phase of growth
excreted and absorbed into systemic system
diffuse through dermal capillaries
attack DMG1
DMG3 in deeper layers of skin protects these layers |
|
|
Term
|
Definition
co infections - pneumonia/sepsis
localised immunosupression
fluid loss from exposed skin
septic arthritis |
|
|
Term
|
Definition
antibiotics
supportive treatment of wounds |
|
|
