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SSRIs
Kaplan and Saddock, Synopsis of Psychiatry 10th ed., Section 36.29
6
Medical
Graduate
09/20/2013
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Term
Which one SSRI has not been approved by the FDA for the treatement of depression?
 Definition
Fluvoxamine
Term
If a patient does not respond to one SSRI, should a different class of drugs be tried?
 Definition
50% of people who respond poorly to one SSRI will respond to another SSRI. It may be prudent to try another SSRI first.
Term
What is the most common adverse effect associated with long-term SSRI treatement?
 Definition
Sexual dysfunction (anorgasmia, inhibited orgasm and/or decreased libido) - 50-80%
Term
What is the mechanism at the base of GI side effects of SSRIs?
 Definition
Effects on the serotonin 5HT3 receptor
Term
What are the five stages of serotonin syndrome?
 Definition

1. Diarrhea

2. Restlessness

3. Extreme agitation, hyperreflexia, autonomic instability

4. Myoclonus, seizures, hyperthermia, uncontrollable shivering, rigidity

5. Delirium, coma, status epilepticus, cardiovascular collapse, death
Term
Which SSRI is least likely to cause a withdrawal syndrome?
 Definition
Fluoxetine
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