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Spring 2009- Pharmacology lecture 1
test 1
22
Health Care
Professional
01/24/2009

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Cards

Term
Drug
Definition
A therapeutic agent other than food used in the prevention, diagosis, alleviation, treatment, or cure of disease in man  and animal
Term
Pharamacology
Definition
The study of drugs
Term
Receptors
Definition
Specific macromolecula components of a organism
Term
Describe the difference between chemical name, generic name, and trade name
Definition

Chem names: discribes its chemical make up

Generic Name: a single name determined by the US Adopted Name Council (written w/o capitalizing 1st letter)

Trade Name: Named by manufacture with  capitalizing letter

Term
Describe ADME
Definition

A-absorption

D-Distribution...liquid/tablets

M- Metabolism...liver

E- Excretion...kidney

Term
Describe chemical equivolency
Definition
Established chemical and physical standards establish regulatory agencies
Term
Biological equivalency
Definition
Drugs must measure the same in the body after comsumption.  There should be no difference between generic vs name brand drugs 
Term

Therapeutic Equivalency

Definition
Once in the body the name brand drug should have the same effect as the generic drug
Term
What is an Adverse Reaction?
Definition
Drugs that act on biological systems lack absolute specificity and act on many other tissues and organs besides their target organs.  And this results in undesirable and adverse drug reactions
Term
Compare Therapeutic vs. Adverse Effects
Definition

Therapeutic-clinically desirable effect of a drug

VS

Adverse-undesirable effects of a drug

Term
What are the 5 catagories of adverse drug effects
Definition

1. toxic reaction

  • predictable
  • dose related(OD)
  • acts on target organ

2. Side effects

  •  predictable
  • dose related
  • acts on all organs not just target organ

3.Idiosyncratic

  • genetically related abnormal response

4.Drug allergy

  • Not predictable
  • Not dose related

5.Interference with natural defense mechanism

Term
When are pregnant women more susceptible to drugs?
Definition
1st trimester
Term
Name 3  common dental drugs that are considered relatively safe?
Definition

lidocaine, penicillin, erythromycin

(generic names)

Term
What drugs should be avoided during pregnancy?
Definition
tetracycline, non-steroidal, anti-inflammatory, benzodiazepines
Term
Describe types of drug interactions.
Definition
  •  
    • Drug to drug
    • Drug to food
    • Drug to disease
    • (example Grapefruit and blood pressure drugs/statins)
Term
Classification of allergic reaction
Definition

Type I

  • Life threatening
  • IgE antibody

Type II

  • IgG or IgM antibodies

Type III

  • Serum sickness(heat in hands and feet)

Type IV

  • contact dermatitis(latex)
Term
Explain LD50 and ED50
Definition
  • LD: Lethal dose kills 50% of the animals tested on
  • ED:Median effective dose the dose required to produce a specified intensity
Term
What is therapeutic index
Definition
  •  
    • TI=LD50/ED50
    • The TI needs to be greater than 10 to be therapeutically safe

 

Term
What is teretogenia?
Definition
  •  
    • Tereto/genia=monster/formation
    •  caused by thalidomide leads to babies born with malformed limbs(phocomelia)
Term
What are the 3 parts of a prescription?
Definition

1.Heading

  • Name address& phone of prescriber
  • Name address age and phone of pt
  • Date written

2.Body

  • RX
  • name and dose size(tabs, capsules, mg/ml)
  • Disp: total amount
  • Sig: Directions(amount, time, frequency, route)

3.Closing

  • Prescribers signature
  • DEA # if RX a controlled substance
  • refill instruction
Term

Can schedule II drugs be called in by phone?

 

Definition

NO

An emerg script can be called in with enough meds for only a 72hr period

Term
Give an example of the 5 drug schedules
Definition

CI: LSD not prescribible

CII: demerol, ridalin no refill no phone in unless a emerg good for a 72 script

CIII: Vicoden can be refilled 1 in 6 months

CIV: Valium refill 1 in 6months

CV: antibotic

 

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