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SPM--Unit 1--Fever-Chronic & Relapsing Fevers
bacteria & protozoa that commonly cause recurrent & relapsing fevers
102
Medical
Graduate
08/27/2010

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Term
What's the gram stain for Ehrlichia chaffeinsis (Monocytic ehrlichiosis)?
Definition
Gram Negative but stain poorly
Term
What's the gram stain for Rickettsiae rickettsii (Rocky mountain spotted fever)?
Definition
Gram Negative but stain poorly
Term
What's the gram stain for Coxiella burnetti (Q fever)?
Definition
Gram Negative but stain poorly
Term
What's the gram stain for Brucella melitensis (Brucellosis, undulating fever)?
Definition
Gram negative
Term
What's the gram stain for Bartonella (Trench Fever, Cat Scratch Fever)?
Definition
Gram negative
Term
What's the gram stain for Borellia burgdorferi (Lyme disease)?
Definition
Gram Negative structure but too thin to detect
Term
What's the gram stain for Borreliae recurrentis and Borrelia Hermsii (relapsing fever)?
Definition
Gram Negative structure but too thin to detect
Term
What's the cell shape for Rickettsiae rickettsii (Rocky Mountain spotted fever)?
Definition
Rod-like coccobacilli--an intermediate shape between coccus (spherical) and bacillus (elongated)
Term
What's the cell shape of Ehrlichia chaffeinsis (monocyte ehrlichosis)?
Definition
Rod-like coccobacilli--an intermediate shape between coccus (spherical) and bacillus (elongated)
Term
What's the cell shape of Coxiella burnetti?
Definition
Rod-like coccobacilli--an intermediate shape between coccus (spherical) and bacillus (elongated)
Term
What's the cell shape of Brucella melitensis (brucellosis, undulant fever)?
Definition
small coccobacilli----an intermediate shape between coccus (spherical) and bacillus (elongated)
Term
What's the cell shape of bartonella(trench fever; cat scratch fever)?
Definition
rods
Term
What's the cell shape of Borellia burgdorferi (Lyme disease)?
Definition
spirochetes
Term
What's the cell shape of borrelia recurrentis (epidemic relapsing fever)?
Definition
spirochetes
Term
What's the cell shape of Borellia Hemsii (endemic relapsing fever)?
Definition
spirochete
Term
What are the growth requirements of Ricketsiae rickettsii (Rocky Mountain spotted fever)?
Definition
Intracellular; endotheliall cells; Require tissue culture or embryonated eggs
Term
What are the growth requirements of Erlichia chaffeinsis (monocytic ehrlichiosis)?
Definition
Intracellular: Monocytes and Mononuclear phagocytes; Can be cultured in mammalian cell lines
Term
What are the growth requirements of Coxiella burnetti (Q fever)?
Definition
Intracellular
Term
What are the growth requirements of Brucella melitensis (brucellosis; undulant fever)?
Definition
Aerobic and Intracellular
Term
What are the growth requirements of Bartonella (trench fever; cat scratch fever)?
Definition
aerobic
Term
What are the growth requirements of the Borrelia genera of bacteria (lyme disease, endemic relapsing fever, epidemic relapsing fever)?
Definition
Borellia have complex nutritional needs. They require N-acetylglucoseamine, long chain fatty acids , glucose, amino acids and other additive to the media for growth
Term
Very high fever and headache. Can also be associated with malaise, muscle aches nausea, macular rash on ankles and wrists.
Definition
Rocky Mountain Fever (Rickettsia ricketsii
Term
the most constant symptom is pain in the legs. sudden onset of high fever, severe headache, pain on moving the eyeballs, soreness of the muscles of the legs and back, and frequently increased sensitivity of the shins. Fever is relapsing—the initial fever is usually followed in a few days by a single, short rise but there may be many relapses between periods without fever.
Definition
Trench fever (bartonella)
Term
tender and swollen regional lymph nodes. There may be a papule at the site of initial infection. While some patients have fever and other systemic symptoms, many do not. Other associated complaints include headache, chills, backache and abdominal pain.
Definition
Cat scratch fever (bartonella)
Term
3 stages:
Stage 1, Localized infection: Erythema migrans (spreading target-like) rash ( 3 to 32 days after bite) + Flu-like symptoms
Stage 2, Disseminated disease: arthritis (damage to the points), arthralgia (joint pain), cardiac complications, neurological complications
Stage 3, Chronic symptoms occur in the third stage
Relapsing 3-6 day fever at 1 week intervals
Definition
Lyme Disease (Borellia burgdorferi)
Term
3-7 days of chills and high fever possibly with splenomegaly
Occurs amid poor living conditions, famine and war in the developing world
Definition
epidemic relapsing fever (Borreliae recurrentis)
Term
3-7 days of chills and high fever possibly with splenomegaly
Found in developed and developed nations
Definition
endemic relapsing fever (Borrelia Hermsii)
Term
Initially non specific: malaise, chills, sweats, fatigue weakness, myalgias (muscle pain), weight loss, arthralgias (joint pains) and dry cough. All patients have a fever which becomes intermittent.
Definition
brucellosis, aka undulant fever (Brucella melitensis)
Term
Months of fevers, night sweats, cough, fatigue. (65% fatal)
Definition
Chronic Q fever
Term
What bacteria causes Rocky mountain spotted fever?
Definition
Rickesttiae Rickettsii
Term
What illness does Rickettisae Rickettsii cause?
Definition
Rocky mountain spotted fever
Term
What bacterial causes monocyte erlichosis?
Definition
Ehrlichia chaffeinsis
Term
What disease does ehrlichia chaffeinsis cause?
Definition
monocyte erlichosis
Term
What 2 illnesses does Coxiella burnetti cause?
Definition
Acute Q fever & chronic Q fever
Term
What bacteria causes undulant fever?
Definition
Brucella melitensis
Term
What illness does burcella melitensis cause?
Definition
undulant fever (aka brucellosis)
Term
What genus of bacteria causes trench fever & cat scratch fever?
Definition
Bartonella
Term
What 2 illnesses does Bartonella cause?
Definition
trench fever
cat scratch fever
Term
What bacteria causes Lyme disease?
Definition
Borellia burgdorferi
Term
What illness does Borellia burgdorferi cause?
Definition
Lyme disease
Term
What bacteria causes epidemic relapsing fever?
Definition
Borellia recurrentis
Term
What illness does Borellia recurrentis cause?
Definition
epidemic relapsing fever
Term
What bacteria causes endemic relapsing fever?
Definition
Borellia Hermsii
Term
What illness does Borellia Hermsii cause?
Definition
endemic relapsing fever
Term
Is Rickettsiae Rickettsii's (Rocky Mountain Spotted fever) metabolism aerobic/anerobic/etc.?
Definition
aerobic
Term
Is Ehrlichia chaffeinsis's (monocyte ehrlichosis) metabolism aerobic/anaerobic/etc.?
Definition
aerobic
Term
Is Coxiella burnetti's (Q fever) metabolism aerobic/anerobic/etc.?
Definition
aerobic
Term
Is Brucella melitensis's (undulant fever, aka brucellosis) metabolism aerobic/anaerobic/etc.?
Definition
Brucella melitensis does not metabolize carbohydrates (but it is aerobic for other reasons).
Term
Are the Borellia genus of bacteria's (Lyme disease, endemic relapsing fever, epidemic relapsing fever) metabolism aerobic/anaerobic/etc.?
Definition
Micro-aerophilic
Term
What is the arthropod vector Rickettsiae rickettsii (Rocky Mountain Spotted Fever)?
Definition
American dog tick
Term
What is the arthropod vector of Ehrlichia chaffeinsis (monocytic ehrlichosis)?
Definition
Lone Star Tick
Term
What is the arthropod vector of Coxiella burnetti (Q fever)?
Definition
no arthropod vector
Term
What is the arthropod vector of Brucella melitensis (undulant fever; brucellosis)?
Definition
no arthropod vector
Term
What is the arthropod vector of Bartonella (trench fever; cat scratch fever)?
Definition
sand flies, lice, fleas
Term
What is the arthropod vector of Borellia burgdorferi (Lyme disease)?
Definition
Ixodes ticks
Term
What is the arthropod vector of Borellia recurrentis (epidemic relapsing fever)?
Definition
lice
Term
What is the arthropod vector of Borellia Hermsii (endemic relapsing fever)?
Definition
ticks
Term
How do you get Brucella melitensis (undulant fever; brucellosis)
Definition
by inhaling dried milk, urine, feces, or placenta from infected (mostly) hoofed animals (Mnemonic: ungulants give you undulant fever)
Term
How do you get Coxiella burnetti (Q fever)?
Definition
by inhaling dried milk, urine, feces, or placenta from infected cattle, sheep, or goats
Term
What's the recurrence pattern for Rickettsiae Rickettsii (Rocky Mountain Spotted Fever)?
Definition
can recur after years of being dormant
Term
What's the recurrence pattern for Coxiella burnetti (Q fever)?
Definition
recurs months to years later in patients with heart valve disease
Term
What's the recurrence pattern of Brucella melitensis (undulating fever; brucellosis)
Definition
continuous, undulating fever (gets better & worse without ever quite going away)
Term
What's the recurrence pattern of the species of Bartonella that causes trench fever?
Definition
5-day intervals of fever & recovery (relapsing)
Term
What is the recurrence pattern of Borellia recurrentis (epidemic relapsing fever)?
Definition
3-6 day fevers at 1 week intervals. Can relapse as many as 10 times.
Term
What is the recurrence pattern of endemic relapsing fever (Borellia Hermsii)
Definition
3-6 day fevers at 1 week intervals. Relapses a few times; sometimes only once.
Term
In what geographical region are you most likely to catch Rickettsiae Rickettsii (Rocky Mountain Spotted Fever)?
Definition
South Central US
Term
In what geographical region are you most likely to catch Ehrlichia chaffeinsis (monocytic ehrlichosis)?
Definition
Southeastern & Eastern US
Europe
Term
In what geographical region are you most likely to catch Coxiella burnetti (Q fever)?
Definition
anywhere in the world except New Zealand
Term
In what geographical region are you most likely to catch Brucella melitensis (undulating fever; brucellosis)?
Definition
worldwide
in the US, it's especially prevalent in California & Texas
Term
In what geographical region are you most likely to catch Borellia burgdorferi (Lyme disease)?
Definition
worldwide, especially Northern hemisphere temperate regions
Term
In what geographical region are you most likely to catch Borellia recurrentis (epidemic relapsing fever)?
Definition
Ethiopia, Rwanda, Andean foothills, and to some extent in Europe
mostly occurs in places experiencing warfare, famine, & bad living conditions
Term
In what geographical region are you most likely to catch Borellia Hermsii (endemic relapsing fever)?
Definition
worldwide
In the US, it's mostly in the west
Term
What is serology?
Definition
diagnosis of disease by identifying antibodies in blood serum
Term
How do you diagnose Rickettsiae Rickettsii (Rocky Mountain Spotted Fever)?
Definition
serology
Term
How do you diagnose Ehrlichia chafereinsis (monocytic ehrlichosis)?
Definition
DNA amplification & serology
Term
How do you diagnose Coxiella burnetti (Q fever)?
Definition
serology
Term
What is cross-reactivity?
Definition
the reaction between an antigen and an antibody which was generated against a different but similar antigen
Term
How do you diagnose Brucella melitensis (undulating fever; brucellosis)?
Definition
serology, but there is significant cross-reactivity (that is, other diseases may give a false positive for Brucella melitensis)
Term
How do you diagnose Bartonella (trench fever & cat scratch fever)?
Definition
clinically & with serology
Term
How do you diagnose Bartonella (trench fever & cat scratch fever)?
Definition
clinically & with serology
Term
How do you diagnose Borellia burgdorferi (Lyme disease)?
Definition
serology only (not microscopy b/c spirochetes of B. burgdorferi enter connective tissue immediately and thus are not found by microscopy of blood)
Term
How do you diagnose Borellia recurrentis (epidemic relapsing fever)?
Definition
microscopy only (not serology b/c of antigenic variation)
Term
How do you diagnose Borellia Hermsii (endemic relapsing fever)?
Definition
microscopy only (not serology b/c of antigenic variation)
Term
What four protozoa cause malaria-like illnesses?
Definition
plasmodium vivax, plasmodium ovale, plasmodium malaeriae, plasmodium falciparum
Term
What are the hosts of the plasmodium (malaria) protozoa?
Definition
mosquitoes, animals, & humans
Term
Which plasmodium accounts for 80% of malaria?
Definition
plasmodium vivax
Term
Which plasmodium only accounts for 15% of malaria, but causes the worst form of malaria?
Definition
plasmodium falciparum
Term
What is the pattern of fever recurrence caused by plasmodium vivax?
Definition
48-hour (2-day) cycle
Term
What is the pattern of fever recurrence caused by plasmodium ovale?
Definition
72-hour (3-day) cycle
Term
What is the pattern of fever recurrence caused by plasmodium malariae?
Definition
72-hour (3-day) cycle
Term
What is the pattern of fever recurrence caused by plasmodium falciparum?
Definition
no recurrence; consistent high fever
Term
Which plasmodium protozoa causes the least severe form of malaria?
Definition
plasmodium malariae
Term
In what geographical region are you most likely to catch plasmodium vivax?
Definition
Asia, Latin America, some parts of Africa
Term
In what geographical region are you most likely to catch plasmodium ovale?
Definition
tropical africa
Term
In what geographical region are you most likely to catch plasmodium malariae?
Definition
worldwide
Term
In what geographical region are you most likely to catch plasmodium falciparum?
Definition
sub-Saharan Africa
Term
What are the target cells of plasmodium vivax?
Definition
only YOUNG RBCs
Term
What are the target cells of plasmodium ovale?
Definition
all RBCs
Term
What are the target cells of plasmodium malariae?
Definition
only MATURE RBCs
Term
What are the target cells of plasmodium falciparum?
Definition
all RBCs
Term
What form (life stage) of plasmodium infects humans?
Definition
sporozoite
Term
What form (life stage) of plasmodium infects mosquitos?
Definition
gametocyte
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