Term
VTE: What makes up Virchow's Triad of factors contributing to thrombosis? |
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Definition
Hypercoagulbility Hemostasis Vessell Wall Injury |
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Term
| Drug Treatments for VTE (5)? |
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Definition
Unfractionated heparin (UFH) Low-molecular weight heparin (LMWH)
Anti Xa Inhibitor
Direct thrombin inhibitors
Vitamin K antagonists
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Term
VTE and Unfractionated Heparin: 1) Anticoagulant effect medicated through a specific pentasaccharide sequence that binds _____which increases it’s affinity for factor IIa (thrombin), IXa, Xa and XIIa by up to 1000 fold 2) Side Effects of Heparin 3) Things to Monitor? |
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Definition
1) Antithrombin 2) Bleeding (2% – 4%) , Heparin Induced Thrombocytopenia, Osteoporosis , alopecia, suppressed aldosterone production 3) aPTT (activated partial thromboplastin time)
ACT (activated clotting time)
Anti-factor Xa activity
Plasma heparin concentrations
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Term
VTE and Low Weight Heparin: 1) Advantages over Unfractionated Heparin? 2) |
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Definition
1) Advantages over UFH
Predictable anticoagulation dose response
Improved subQ bioavailability
Dose-independent clearance
Longer biologic t1/2
Reduced need for routine laboratory monitoring |
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