Shared Flashcard Set

Details

Smoking Cessation
Longo
43
Bartending
12th Grade
06/18/2014

Additional Bartending Flashcards

 


 

Cards

Term
What is the cause of the majority of ADRs in smoking (including CA)?
Definition
Toxins (not nicotine)
Term
Quitting for how long will lead to significant decrease in risk of CVD?
Definition
1-3 years
Term
What 4 things are smoking related factors that lead to CVD?
Definition
Increased thrombogenesis, CO, Oxidative damage, Hyperlipidemia
Term
What is the greatest ADR of nicotine?
Definition
Addiction
Term
T or F: Nicotine is depressant and not a stimulant.
Definition
False it is both
Term
Where is nicotine absorbed when smoked?
Definition
Both the mouth and the respiratory tract.
Term
Nicotine binds to ______ receptors in CNS, RS, NS and ______?
Definition
Nicotinic, Autonomic Ganglia
Term
Nicotine has ___ chronotropic and ____ ionotropic effects on the CV system?
Definition
Positive,positive
Term
What does nicotine increase in the CV system?
Definition
Cardiac output and BP
Term
ADRs and MOA of buproprion?
Definition
Seizure Risk with doses >450mg/day or 150mg at 1 time. Insomnia, dry mouth. MOA is weak inhibitor of NE, Ser and Dopa uptake
Term
Buproprion and nicotine patch have what ADR when combined?
Definition
increased risk of HTN
Term
Buproprion dose/instructions
Definition
Start 2 wx before quitting. 150mg PO qAM x 3 days, then 150mg BID x 7-12 weeks. May use up to 6 mo.
Term
Varenicline (Chantix): Cat? MOA?
Definition
Cat: C. MOA: Partial nicotinic,ACH receptor agonist. Reduces cravings
Term
Varenicline (Chantix): Common ADRS and precautions
Definition
common GI probs, sleep disturbances (abnormal dreams). Take with full glass of water.
Term
Which first line pill for smoking sessation is associated with behavioral/psych ADRS
Definition
Varenicline
Term
Varenicline dosing/instructions
Definition
Start 1 wk before quitting and continue for 12 weeks. If quits continue for 12 more weeks. Dose: Days 1-3 0.5 mg PO QD. Day 4 0.5 mg PO BID. Day 8 and on 1mg PO BID
Term
Two second line agents used to quit smoking but not FDA approved
Definition
Clonidine and nortriptyline
Term
What is the best way to increase success with quitting smoking?
Definition
Pharm therapies w/ counseling or behavioral therapy
Term
Different effects of nic on resp systems (high dose vs low dose)
Definition
Low dose increases respirations by activating chemoreceptors in aortic arch and carotid bodies. High dose dose it by directly stimulating resp center. Toxic dose leads to respirtory depression by inhibiting resp centers in breain stem and acting on NMJ
Term
Nicotines actions on CNS cause
Definition
Appetite supression, mild euphoria, increased memory, concentration and arousal, tremors, convulsions, NV
Term
BBB and placenta / nicotine
Definition
Nic cross BBB and placenta
Term
What induces nicotine metabloism?
Definition
The tar from smoking via CYP450
Term
nicotine can induce metabolism of what 4 things?
Definition
Opioids, BDZ, Beta Blockers and Theophyline
Term
The three methods of quitting?
Definition
Aversion therapy (common w/ accupunture or hypnosis). Abrupt Withdrawl, NRT
Term
The 5 As for patient willing to quit smoking
Definition
Ask, Advice, Assess, Assist,Arrange
Term
The 5 Rs for patients not interested in quitting smoking
Definition
Relevence (determine benefits), Risk, Rewards, Roadblocks, Repetiton (nag them)
Term
To decrease addiction NRT administration of nicotine differs from cigarettes how?
Definition
The dose is lower and given more gradually.
Term
Which NRT is most similar to cigarettes when it comes to amount of nicotine in blood?
Definition
4mg Gum
Term
Safety of NRT in CVD?
Definition
NRT is safe in CVD even w/ smoking combo
Term
T or f: NRT increases risk of acute MI
Definition
False it does not.
Term
Nic gum dosing/duration?
Definition
For someone that smokes less than 24 cigs a day it is 2mg x24 max. For someone that smokes more its 4mg x 24 max. Max duration is 12 weeks.
Term
Nic gum ADRs
Definition
Dyspepsia, oral sores.
Term
Nic Inhaler doses and ADR
Definition
6-16 cartridges/day x 6mo. ADR: mouth/throat irritation
Term
Nic inhaller instructions
Definition
Best effects with continuous frequent puffing for 20 min
Term
Nic Nasal spray dose/duration/Adr
Definition
1-2 sprays per house (2 sprays=1mg). Max = 5 mg (10 sprays) per hour or 40 sprays per day. Durration: 3-6mo. ADRs=Nasal irritation
Term
Nic Patch Dosing:
Definition
21mg/24 hours x 4 weeks. Then 14 mg/24hrs x 2 weeks, then 7mg/24 x 2 weeks.
Term
Which patch comes in what alternative doses?
Definition
Nicotrol comes in 15mg, 10mg, 5mg
Term
ADRs of Nicotine patches
Definition
local skin reaction, insomnia, vivid dreams, vasospasm at the site of the patch
Term
How do you determine the dose to give of nicotine lozanges?
Definition
A smoker that needs a cig within 30 min of waking is given 4mg lozenge, if they don’t need it that early they get 2 mg lozenge
Term
Nicotine lozange dose schedule
Definition
1 lozange q 1-2 hours x 6wx, then decrease to every 2-4 hours for 3 weeks, and finally every 4-8 for the last 3 weeks.
Term
Effects of nicotine on fetus?
Definition
It may be a teratogen, can lead to obstretrical complications and possibly SIDS. Thought the benefits of NRT outweight the risks so pts are advised to proceed.
Term
NRT can be combined with what drug to reduce cravings?
Definition
Buproprion
Term
Which drug concidered to be first line is still not part of the official guidelines?
Definition
Varenicline
Supporting users have an ad free experience!