Term
|
Definition
| Normal size cells, low reticulocytes, low serum iron |
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Term
|
Definition
| High Ferratin, High hepcidin |
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Term
|
Definition
| Microcytic anemia, target cells, basophilic stippling, normal or slightly raised Fe, raised ferritin |
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Term
|
Definition
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|
Term
| 30-300 for women, 15-200 for men |
|
Definition
| Ferritin reference ranges |
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Term
|
Definition
| Biochemical defect in DNA synthesis causes impaired cell division, but cytoplasm still orderly |
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Term
|
Definition
| Autoimmune gastritis followed by gastric atrophy causes... |
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Term
|
Definition
| Antibodies to parietal cells and IF found in peripheral blood |
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Term
|
Definition
| Low HCL in stomach, low IF |
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Term
|
Definition
| Tests for IF deficiency vs. malabsorbtion |
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Term
|
Definition
| Low RBC lifespan, low haptoglobin, high bilirubin, high LDH |
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Term
|
Definition
| Low serum B12, high Methylmalonic acid, high homocystiene |
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Term
|
Definition
| breakdown product of protoporphyrin |
|
|
Term
1. Hgb-Haptoglobin
2. Hgb-albumin (Methemalbumin)
3. Hgb |
|
Definition
| Three things appearing in urine with increasing levels of hemolysis |
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Term
|
Definition
| Hemolytic anemia targeting P antigen (globoside) |
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|
Term
|
Definition
| erythema infectiosum (fifth disease- "slapped face") |
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Term
|
Definition
| Increased osmotic fragility (RBCs lyse when exposed to hypotonic solutions) |
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|
Term
| Autohemolysis test- culture cells 48 hours and see if they autohemolyze |
|
Definition
| Test used to diagnose hereditary spherocytosis |
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Term
|
Definition
| RBC inclusions from precipitates. "Pitted" by spleen (chunk of RBC removed- RBC may turn into spherocyte) |
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Term
|
Definition
| Increases level of fetal Hemoglobin F- in treatment of Sickle Cell or malaria |
|
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Term
|
Definition
| danger posed by platelets, neutrophils, dehydration in sickle cell |
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|
Term
|
Definition
| worst complication of sickle cell |
|
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Term
|
Definition
| Splenomegaly, retinopathy, aseptic necrosis of bone |
|
|
Term
| Warm autoantibody hemolytic anemia (IgG) |
|
Definition
Fc receptor mediated (RES) destruction
Low levels of C3b inactivated to C3d
Extravascular hemolysis |
|
|
Term
| Cold agglutinin hemolytic anemia (IgM) |
|
Definition
Agglutination of RBC in cold (4°C)
Complement fixation → Cell lysis
Intravascular hemolysis |
|
|
Term
| Direct antiglobulin test (Coombs' test) |
|
Definition
| Test for autoimmune hemolytic anemia |
|
|
Term
| Indirect antiglobulin test (Coombs' test) |
|
Definition
|
|
Term
| Chronic cold agglutinin disease (CAD) |
|
Definition
| Direct Coombs' test positive for complement and negative for IgG. High reticulocytes |
|
|
Term
| Cold agglutinin disease (CAD) |
|
Definition
| Mild anemia, high reticulocytes, agglutination visible to naked eye |
|
|
Term
| Microangiopathic hemolytic anemia (MAHA) |
|
Definition
| RBC Schistocytes on Peripheral blood smear |
|
|
Term
|
Definition
| Exposed under high shear. Binds GP1b |
|
|
Term
|
Definition
| Bound by fibrinogen to begin platelet aggregation |
|
|
Term
| Platelets <50% or 100,000 with no other cause of thromboctyopenia other than heparin. Discontinue heparin IMMEDIATELY!! |
|
Definition
| Clinical diagnosis of HIT |
|
|
Term
| Ideopathic Thrombocytopenic Purpura (ITP) |
|
Definition
| Autoimmune IgG against platelet glycoproteins. |
|
|
Term
| Thrombic Thrombocytopenic Purpura (TTP) |
|
Definition
| MAHA, thrombocytopenia, fever, renal abnormalities, CNS in YOUNG WOMAN (mostly) |
|
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Term
|
Definition
| test for intrinsic pathway |
|
|
Term
|
Definition
| Autosomal dominant, mucocutaneous bleeding (bruising, epistaxis, menorrhagia), prolonged PTT |
|
|
Term
|
Definition
| Most common inherited coagulopathy |
|
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Term
|
Definition
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|
Term
|
Definition
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|
Term
|
Definition
| Vitamin K dependent coagulation factors |
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Term
|
Definition
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