Erythema Infectiosum (Fifths Disease)

Fetal hydrops fetalis, miscarriage

Transient aplastic crisis (TAC)

Arthralgia, Arthritis

Virus assoc. hemophagocytic syndrome

Spread by respiratory droplets, blood

Seasonal -late winter/early spring

fever

hydrops fetalis, TAC, hemophagocytic

virus targets RBC precursors in bone marrow

p-antigen that virus attaches to and you get transient depletion

immune complexes

rash, arthritis, arthralgia

fever and pruritic rash, arthalgia

2 stages fever -> rash

viremia

Increased IgM and IgG, leukocytes = rash + arthralgia

rash prior to immune response

No bone marrow infection

Infection in capillary endothelial cells

viremia, fever, rash - same time

transpacental transmission

greatest chance b/t 11 - 23 wks gestation

fatality rate 50%

anemia, cardiac failure, death

follows B19 infection of pts w/ sickle cell disease

TX: transfusion

Clinical symptoms - "lacelike" rash

IgM ELISA

PCR - only during fever

Bone marrow path (aplastic crisis) -normoblasts

causative agents of benign tumors (warts)

responsible for 95% of malignant cervical carcinoma

Papovaviruses w/ subgroups

Papilloma

Polyoma - BK (kidney infection subclinical); JC (encephalomyelitis)

circular dsDNA

overlaping genes disrupt p53/Rb

dry skin warts:

common, plantar, flat

EV, bowenoid

Condylomas

(mucocutaneous warts)

highest potential for malignancy

laryngeal warts CD 6,11

bowenoid papulosis CD 16,18

intermediately malignant

cervical dysplasia

viral replication house within epidermis

have to have cut, bruise, scrap- has to get to basal layer where cells w/ receptor are. Basal layer - no viral replication/express.

Basal layer transforms self - expression

Prickle cell layer - full viral gene expression