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Skin Infections
Dermatology
40
Dentistry
Professional
11/16/2013

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Term
Folliculitis
Definition

Pyoderma localized within hair follicle and the apocrine regions; lesions consist of small erythematous, sometimes pruritic papules often topped by a central pustule.

Agents: Staph aureus; pseudomonas aeruginosa; enterobacteriaceae (acne) Candida

Term
Foruncle
Definition
Deep inflammatory module, develops from preceding folliculitis
Term
Carbuncle
Definition
Process is more extensive, extending into the subcutaneous fat in areas covered by thick inelastic skin. Drain to the surface along hair follicles.
Term
Treatment for folliculitis
Definition
Local measures, saline compresses, topical antimicrobials
Term
Treatment for furuncle and carbuncle
Definition
Moist heat (promotes localization and drainage), antibiotics, surgical drainage
Term
Impetigo
Definition
Superficial infection of the skin, highly communicable, clinically and bacteriologically can be subdivided into two distinct subtypes (impetigo contagiosa, bullous impetigo), typically occurs in children and young adults, often begins as a single lesion but then multiple lesions develop
Term
Impetigo contagious
Definition

Begins as small vesicles that rapidly pustulate and readily rupture. With drying of the purulent discharge, characteristic thick, golden yellow crust are formed. Lesions remain superficial, no ulceration or infiltration

Common sites: exposed areas; pruritis is common

Term
Etiology of impetigo contagiosa
Definition
Previously most cases (80%) were caused by Strep pyogenes, recently only 20-30%, most common agentĀ  - Staph aureus; necessity to treat because of sequelae of S. pyogenes infections
Term
Pathogenesis of impetigo contagiosa
Definition
The bacteria enter the epidermis through breaks in the stratum corneum caused by trauma and produce infection
Term
Therapy for impetigo contagiosa
Definition
Presently penicillinase resistant penicillins (S. aureus), erythromycin, cephalosporin; Mupirocin, topically, effective when few lesions are present
Term
Bullous impetigo
Definition
Begins as vesicles, evolving into large bullae that persist for days. When the bulla ruptures it leaves an erythematous base with a varnish like thin brown crust.
Term
Differential diagnosis of bullous impetigo
Definition
Herpes virus infections, contact dermatitis, fungal infections
Term
Etiology of bullous impetigo
Definition
Staph aureus
Term
Pathogenesis of bullous impetigo
Definition
Staph toxins produced at the site of lesion cause the subcorneal cleave characteristic of bullous impetigo
Term
Therapy for bullous impetigo
Definition
Penicillinase resistant penicillins or erythromycin
Term
Acne definition
Definition
Inflammatory follicular, papular and pustular eruption involving a sebaceous apparatus.
Term
Mechanism of acne
Definition

Propionibacterium acnes (critical); blocked follicles become anaerobic culture medium filled with nutrients (lipids)

Free fatty acids --> retention hyperkeratosis --> microcomedo formation

Term
Treatment for acne
Definition
Benzoyl peroxide (Clearasil and ProActiv) Topical antibiotics - Clindamycin, erythromycin, tetracycline
Term
Definition of warts
Definition
Benign tumors of the skin and mucous membranes caused by infection of epidermal cells with papillomavirus
Term
Pathogenesis of warts
Definition
HPV infects and replicates in keratinizing cells in the epidermis; the presence of the virus stimulates epidermal proliferation, resulting in epidermal thickening and hyperkeratosis
Term
History of warts
Definition
Immunosuppression, working as a butcher/meat cutter
Term
Therapy of warts
Definition
Treatment of warts is nonspecific, destructive, and usually painful. The goal is destruction of the keratinocytes that are infected with HPV. There are a variety of physical (cryotherapy, desiccation and curettage, and excision); chemical (salicyclic acid, lactic acid, podophyllin, and tretinoin), and biologic (DNCB) modalities used to treat warts and the choice of therapy is determined by the number, size and location of the lesions.
Term
Definition of molluscum contagiosum
Definition
Viral infection of the skin w/ characteristic morphology
Term
Pathogenesis of molluscum contagiosum
Definition
Molluscum virus replicates in the cytoplasm of the keratinocyte, resulting in eosinophilic cytoplasmic inclusion bodies and proliferation of the epidermis
Term
History of molluscum contagiosum
Definition
Molluscum contagiosum is a common childhood disease
Term
Physical examination of molluscum contagiosum
Definition

The papules are 2-5 mm, hard, smooth, dome-shaped and flesh-colored or translucent

They have a central umbilication

Occur singly or in groups, most commonly on the trunk, face and extremities of children or on the genitalia of sexually active adults

Term
Differential diagnosis of molluscum contagiosum
Definition
Basal cell carcinoma
Term
Therapy of molluscum contagiosum
Definition
Curettage or cryotherapy w/ liquid nitrogen
Term
Fungal infections (mycoses)
Definition

Superficial infections (of concern because of their cosmetic appearance)

Cutaneous infections caused by dermatophytes, which are restricted to the keratinized tissues - the nails, hair and stratum corneum of the skin; subcutaneous infections; deep seated systemic infections that cause debilitating and fatal diseases

Candida infections

Term
Dermatophytoses definition
Definition
Infection of skin by fungi collectively called dermatophytes
Term
Pathogenesis of dermatophytoses
Definition

Dermatophytes grow on humans, animals, and exist in soil

They are keratinophilic (feed on keratin). They produce keratinases, a necessary requirement for their keratinophilia

Stratum corneum, hair and nails are substrates

Dermatophytes do not invade beyond the epidermis because of 1. their dependence on keratin for nutrition and 2. fungistatic properties of human serum; typically dermatophyte infections spread in a centrifugal pattern showing a "ringworm" appearance

Term
Tinea description
Definition
Used for infections. It is followed by a qualifying term that denotes the location of the infection
Term
Therapy for dermatophytes
Definition
Infections involving only limited areas - topical antifungal agents (until the infection is clinically clear and then for an additional 1-2 weeks); widespread disease or scalp disease: systemic therapy is indicated
Term
Athlete's foot
Definition
= ringworm of food; spread from human to human indirectly through contaminated floors, towels, combs, bed linens. Warmth and moisture required. In the Western World - 30-70% of population is infected, most cases are subclinical
Term
Symptoms of athlete's foot
Definition
from peeling and cracking of the skin to acute ulcerative form
Term
Chronically infected individuals with Athlete's foot
Definition
develop hypersensitivity to the fungus, an allergic response follows (vesicles on the hands, testing by a skin test)
Term
Definition of scabies
Definition
An infestation of the skin with Sarcoptes scabiei mite. It is acquired by close contact with an infected person
Term
History of scabies
Definition
Cardinal symptom is severe unrelenting pruritis, which is frequently more intense at night. Itching usually begins 1 month following infestation with the mite. It is due to sensitization to the mite protein
Term
Physical exam of scabies
Definition
Skin lesions consist of erythematous papules, pustules, vesicles (esp. in infants) and nodules; pathognomonic linear burrows, rarely longer than 1 cm are not seen in all patients; once pruritis devs, excoriations (=scratch marks) are seen in addition to the primary lesions; distribution of lesions is diffuse w/ greater concentrations on the hands and feet, particularly the interdigital webs, and in the body folds (axillae, groin and fingerwebs)
Term
Treatment scabies
Definition
All family members and close contacts must be treated, topical agents that kill mites and ova: permethrin, lindane, crotamiton and sulfer 5-10% in petrolatum; antihistamines are helpful for pruritis, esp at night.
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