Term
What are host factors of the skin? |
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Definition
- Surface is dry, not conducive to growth - Renewal of epidermidis - Sebaceous secretion - FFA **disruption by puncture or abrasion, DIABETES |
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Term
What factors predispose for skin infections? |
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Definition
- High bacteria conc - Excessive moisture - Inadequate blood supply - Presence of bacterial nutrients - Corneal layer disruption |
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Term
What pathogens cause soft tissue infections? |
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Definition
- S. Aureus and S. pyogenes are the majority - May be MRSA - P. Aerug - Enterococci or E. coli *** Usually gram(+)!! |
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Term
What are primary infections? |
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Definition
Not caused by underlying disease or deep wounds: - Erysipelas - S. pyogenes - Impetigo - S. aureus, S. pyogenes - Cellulitis - S. pyogenes - Necrotizing fasciitis - 2 types * Type I - Anaerobes * Type II - S. pyogenes |
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Term
What are the 2 types of skin infections? |
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Definition
- Uncomplicated - Superficial, usually gram(+) - cellulitis, impetigo, abcess, furuncles - Complicated - gram(+) or (-) - ulcers, fasciitis, Cellulitis, or gangrene |
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Term
How is MSSA-caused skin infections treated? |
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Definition
1st choice - Nafcillin or a 1st gen Cef (Cephalexin or Cefazolin) Can also use Clinda, Diclox, or bactrim |
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Term
What are treatment options for MRSA-caused skin infections? |
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Definition
- Standard: Vancomycin - Linezolid - serotonin syndrome, platelets, optic neuropathy - Daptomycin/Cubicin - Causes Rhabdo! - Tigecycline/Tigracil - A static drug - Ceftaroline - no Pseudomonal activity |
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Term
How is Community acquired MRSA skin infection treated? |
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Definition
Reserve newer antibiotics for deep seated infections - go with bactrim or tetras |
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Term
What is the best way to treat decolonized MRSA? |
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Definition
Mupirocin BID x5 + Chlorhexidine baths |
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Term
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Definition
An acute infection affecting the epidermis and dermis that can move to the fascia --> abscess, osteomyelitis, septic arthritis, thrombophlebitis **S. pyogenes, S. aureus, H. influenzae (1-5) |
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Term
What type of cellulitis often has mixed infection? |
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Definition
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Term
How does cellulitis present? |
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Definition
- Area feels hot and warm - Lesions - may be extensive - Fluid gram stain often negative |
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Term
How is cellulitis treated? |
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Definition
- Staph - Dicloxillin (mild), Bactrim (moderate), Nafcillin (severe) - Strep - PCN - Gram(-) - Cefuroxime - Polymicrobe - AMG + nafcillin **w/ anaerobes - clinda or metronidazole **Tx as a staph infection unless documented strep!! |
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Term
How is MRSA treated for skin infections? |
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Definition
- Incision and drainage is necessary - Purulent - Clinda, Bactrim, tetra - Non-purulent - beta lactam or clinda |
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Term
What is necrotizing fasciitis? |
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Definition
A highly lethal soft tissue infection - Initially hot, no sharp margins - bullae filled with liquid --> gangrene **HAVE to do surgical exploration |
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Term
What are the 2 types of necrotizing fasciitis? |
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Definition
Type I - after trauma and IVDA - caused by anaerobes Type II - S. pyogenes, more virulent **Tx: Clindamycin most effective for type 2. Otherwise broad spectrum |
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Term
What is clostridial myonecrosis? |
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Definition
Gas gangrene - involves skeletal muscle Caused by Clostridium perfringens **Tx: PCN + clinda + hyperbaric O2 |
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Term
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Definition
Nonbullous form - most common, caused by S. pyogenes. Bullous - in kids, S. Aureus HIGHLY contagious - lesions --> itchy blisters. Diagnosis by culture |
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Term
What drugs treat impetigo? |
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Definition
- Dicloxillin, Cephalexin, Cefadroxil, Clinda x7-10 days - PCN injection - Mupirocin oint - Clinda in PCN allergy |
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Term
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Definition
St. Anthony's fire - in the very young and very old. Lesions bright red w/ edema. Caused by S. pyogenes **Tx: PCN or clinda |
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Term
What is folliculitis/furuncles/carbuncles? |
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Definition
- Folliculitis - Caused by S. aureus or by P. aerug from swimming. Self limiting, can use warm compresses. - Furuncles - A red nodule spreads to dermis. May need to drain. TX: Diclox or Clinda - Carbuncles - Extends to subcutaneous, fever. Same tx. |
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Term
What causes diabetic foot? |
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Definition
- Neuropathy - absence of pain, dry cracked skin - Angiopathy/ischemia - ischemia breaks down skin - Immune defects - impaired phagocytosis = susceptible to infection. Normal humoral |
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Term
What pathogens are involved in diabetic foot? |
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Definition
Polymicrobic! Often has anaerobes Staph and Strep + gram(-) (E.coli,Klebsiella, proteus, P. aerug) + Anaerobes (Bacteroides) |
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Term
What is the main complication from diabetic foot? |
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Definition
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Term
What should NOT be done when collecting diabetic foot cultures? |
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Definition
- Culture uninfected lesions - Obtain culture without first debriding wound - Obtain culture by swabbing wound **Has to be deep wound culture |
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Term
How is diabetic foot empirically treated? |
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Definition
- Mild - Cephalexin or Augmentin - Moderate - Ampi/sulbactam or Ertapenem or Imipenem, Vanc for MRSA, Zosyn for Pseudomonas |
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Term
How are dog bites treated? |
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Definition
80% of all animal bites - caused by Pasteurella multocida **Tx with Augmentin, bactrim in PCN allergy. Cat bites have more risk of osteomyelitis |
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Term
What is found in human bites? |
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Definition
Higher risk of infection by strep, staph, Eikenella, Anaerobes **Aggressive irrigation and debridement - Augmentin, Doxy, diclox, PCN. **Serious infection: cefoxitin, Ampi/sul, ertapenem **PCN allergy: Metronidazole or Clinda |
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