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skin cancer
skin cancer
41
Medical
Undergraduate 2
05/20/2009

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Cards

Term
epidemiology of melanoma
Definition
qld highest rate in the world, 5 cause of cancer deaths, 5 % of skin cancers, morality stablising, 10yr survival 92%
Term
risk factors for melanoma
Definition
family history, fair skin, dysplasitic naevus, exposure to UV light,
Term
evaluting a pigmented lesion
Definition
change - assymetery, border, colour, diameter <6mm, Elevation. Seven point list - Major - change in size, shape, colour. Minor - size >6mm, itch, crusing, inflammation
Term
DDx of pigmented lesion
Definition
pigmented BCC, seborrheic keratosis, solar keratosis, dermatofibroma, lentigo, freckle, Non-pigmented lesions, heamangioma
Term
Prognostic indicatiors
Definition
Breslows thickness, clarkes levels, ulceration, lymph node status, age, metastatis, low mitotic rate, infiltrating lymphocytes sex,
Term
Breslows thickness
Definition
T1 <1mm, T2 1-2mm, T3 2-4, T4>4
Term
clarkes levels
Definition
1. melanoma in situ, 2. invasion of the papillary dermis, 3 tumour filling the papillary dermis, 4 tumour invasion of the reticular dermis, 5 tumor invading the SC fat
Term
treatment of melanoma
Definition
Excision (2mm) punch or shave biopsy. Resection margins - insitu 0.5cm, Invasive 1-2cm.
Term
type of melanoma
Definition
superficial spreading, Nodular, lentigo maligna, Acral lentiginous, amelanotic, desmoplastic
Term
risk factors for non melanoma
Definition
UV exposure, fair skin, radiation, HPV infection, Genetic, chronic inflammatory lesions, immunosuppression
Term
SCC precursors
Definition
solar keratosis
Term
types of pigmented lesions
Definition
freckle, lentigo, benign melanocytic naevus (junctional, compound, intradermal), spitz naevus, halo naevus, congenital naevus,
Term
dysplastic naevus
Definition
variable colour, border, larger. no differentiation, atypical proliferation, difficult to distinguish from melanoma initu. may occr in familias yndromes. increased risk of melanoma
Term
growth of melanoma
Definition
atypical melanocyte hyperplasia, melanoma in situ, predominant radial phase (lymphatic responce), vertical phase into the reticular dermis and beyond, metastasis
Term
seborrheic keratosis
Definition
proliferation of keratonocytes, common in elderly, well demarcated raised plaque with stuck on appearance, confused with melanoma, benign
Term
solar keratosis
Definition
premalignant dysplastic lesion, rough scaling, pooly demarcated plaques with parakerotic scale. related to excessive skin exposure
Term
basal cell carcinom
Definition
most commonn skin cancer, tumor of basaloid cells, result from sun damage, appear as pearly noduel with telangiectasia and rolled border. locally agressive ulcerate and bleed, very rarely metastasise
Term
cataract
Definition
lens opacity causing gradual loss of vision cause - Age, congenital, DM, corticosteroids, uveitis, trauma. present with gradually deminishing vision, loss of red reflex
Term
glaucoma
Definition
slowly progressive optic neuropathy due to raised ocular pressure. unknown cause, usually asymptomatic. presentation at routine screeing or enlargement of the cup to disk ration of fundoscopy
Term
macular degeneration
Definition
gradual bilateral loss of central vision. cause age
Term
diabetic retinopathy
Definition
affects most diabetics, causes proliferation of vessel and leads to blindness from vitreos haemorrage, retinal detachment and glaucoma
Term
Bad red eye symptoms
Definition
pain, photophobia, poor vision, pus, pupil abnormality
Term
patterns of visual field loss
Definition
optic nerve - loss of vision in one eye, RAPD. Chiasm - Bitemporal hemianopia. Retrochiasma - homonymous heminaopia
Term
what is a birth cohort
Definition
group of people born in the same are who faced same societal circumtances
Term
psychosocial factors afecting the aging process
Definition
prosonality traits, anxiety and depression, stress, social support
Term
Dr role in assessing driving
Definition
identification of at risk drivers, warings of affect of disease on driving, medical assessment of drivers.
Term
High risk motor vechile groups
Definition
epilepsy, alcohol abuse, dementia, psychiatric disorder, sleep apnoea, youth,
Term
asessment of elderly drivers
Definition
age 75, visual and medical tests every five years. consider physical and cognitive ability required to drive
Term
types of prevention
Definition
primary - prevent the occurance, secondary - early recognition of disease or risk factors, tertiary - reducing the complications of the disease
Term
High risk strategy
Definition
adanvtages- cause and effect, avoids unaffected, good cost benefit. Disadvatage - limited to health care model, inability to predict high risk, small ability of change, doesnt target underlying problem
Term
Mass strategy
Definition
advantage - large scale effect, addresses underlying social causes, Disadvantages - difficult to persuade entire population, expensive, not inline with political paradigms
Term
population attributable risk
Definition
measure of disease burden. the percentage reduction in disease if there was no exposure at all. combines relative risk with prevelance
Term
ideal screening program
Definition
1. right disease - severe, common, public health issue, good understanging of history, long lead time. 2 Right test - accurate, reliable, safe, accepable, simple, cheap. 3 Right program - effective, cheap, able to cope with increase in disease
Term
harms of screening
Definition
false positive, false negatives, inconsiquential diagnosis, labelling the diseased
Term
layers of the eyeball
Definition
1. sclera and cornea. 2. choroid, cilliary muscle, iris. 3. retina
Term
extraocular muscles and nerves
Definition
SO4, LR6, RES3
Term
UV damage and skin cancer
Definition
chronic UVA exposure creates reactive oxigen species and damage to chromophores as well as inducing immune supression by langerhans cell depletion. creation of pyrmidine dimers causing DNA mutation an dskin cancer
Term
UV damage and skin cancer
Definition
chronic UVA exposure creates reactive oxigen species and damage to chromophores as well as inducing immune supression by langerhans cell depletion. creation of pyrmidine dimers causing DNA mutation an dskin cancer
Term
treatment options for SCC
Definition
excision, cryosurgery, lymph node dissection, systemic chmotherapy
Term
treatment of a BCC
Definition
electrodessication ad curettage, excision, cryosurger, radiation, fopical 5FU, aldara
Term
classification of neoplasms
Definition
type, histological grade - differentiation, mitosis, pleomorphiss, lymphocytic infiltration. Stage - TMN system
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