Term
1)protection 2)sensation 3)thermoregulation 4)metabolic functions |
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Definition
list the four main functions of skin |
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Term
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Definition
what is the largest organ of the body and what percent body mass does it take up? |
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Term
epidermis, dermis, hypodermis (subcutis) |
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Definition
name the 3 layers of skin |
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Term
1)UV, 2)mechanical, 3) chemical, & 4)thermal insult. 5) Prevents dehydration 6) Barrier to microbes |
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Definition
what does skin protect against? |
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Term
skin senses: pressure pain and temperature |
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Definition
what is the largest sense organ in the body, what does it sense? |
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Term
insulation via Sub Q fat heat loss facilitated by sweat glands & dermal capillary network |
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Definition
how does skin thermoregulate? |
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Term
energy stored in subQfat (triglycerides) Vitamin D synth'd in skin with sunlight maintains homeostasis excretory fxn: sweating immune defense |
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Definition
what are the metabolic functions of skin? |
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Term
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Definition
consists of keratinized, stratified squamous epithelium |
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Term
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Definition
normal epidermis cells called this |
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Term
thickness of EPIdermis, not all 3 layers |
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Definition
what does thick/thin skin depend on? |
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Term
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Definition
what range can skin vary in thickness from? |
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Term
volar soles, and palmar surfaces |
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Definition
where is thick skin found |
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Term
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Definition
does thick skin have hair? |
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Term
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Definition
thick skin has a thick highly _____ layer |
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Term
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Definition
most of the body is covered in _____(thick/thin) skin with _____ keratinized epidermis |
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Term
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Definition
are there blood vessels in the epidermis or its basement membrane? |
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Term
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Definition
are there blood vessels in the epidermis or its basement membrane? |
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Term
dermis (supplies the epidermis) & hypodermis |
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Definition
what layer are the blood vessels found in skin? |
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Term
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Definition
layer of skin composed of dense irregular collagenous connective tissue interspersed with elastic fibers |
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Term
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Definition
what type of collagen is found in the dermis |
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Term
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Definition
progressive damage to elastic fibers in this layer(from sunlight) causes aging and loss of skin tone |
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Term
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Definition
highly vascular layer of skin with many sensory receptors |
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Term
papillary layer, deep reticular layer |
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Definition
name the 2 layers of the dermis |
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Term
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Definition
relatively thin layer that interdigitates with the epidermis corrugations increase surface area for attachement and prevent shear and mechanical abrasion |
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Term
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Definition
epidermal projections into dermis |
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Term
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Definition
dermal projections into the epidermis |
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Term
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Definition
large dermal ridges in thick skin |
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Term
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Definition
what is the name of the study of fingerprints? |
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Term
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Definition
thicker and less cellular layer of dermis |
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Term
reticular layer of dermis |
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Definition
what layer of the skin contains hair follicles, sweat, and sebaceous glands? |
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Term
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Definition
thick collagen bundles and elastin fibers in reticular layer form lines of tension called ____ |
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Term
incisions made parallel to the lines cut between the collagen bundles and leave less scarring when they heal |
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Definition
what is clinically significant about Langer's lines? |
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Term
subpapillary plexi, cutaneous plexi, subcutaneous plexi |
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Definition
name the 3 vascular plexi in skin |
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Term
subpap-at junction or papillary and reticular dermis
cut-located at junction of reticular layer and hypodermis
sub Q-deep in hypodermis |
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Definition
where are the subpapillary plexi, cutaneous plexi, and subcutaneous plexi found? |
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Term
subcutaneous plexi, fingertips and ears |
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Definition
which vascular plexi of the skin is used in thermoregulation, and where in the body? |
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Term
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Definition
thickened regions of smooth muscle in wall of arterioles surrounded by CT capsule |
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Term
re-route blood from atrial to venous circulation by bypassing the capillary bed
=AV shunt |
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Definition
what do glomus bodies do? |
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Term
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Definition
layer of loose, irregular CT and adipose |
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Term
subcutis, superficial fascia, panniculus adiposus |
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Definition
other names for the hypodermis |
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Term
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Definition
how long does it take a skin cell to travel from the deep germinal layer, mature, and be sloughed off(desquamated)? |
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Term
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Definition
what disease causes immature, irregular keratinocytes that mature in only 1 wk |
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Term
absence of a granular layer, abnormal keratohyaline and tonofibrils |
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Definition
in psoriasis, besides the lifespan of the skin cells, what is irregular about them? |
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Term
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Definition
what shape are the cells of the stratum basale? |
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Term
BM: hemidesmosomes dermis: anchoring filaments and microfibrils |
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Definition
how is the stratum germinativum anchored to the basement membrane? the dermis? |
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Term
stratum basale/germinativum |
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Definition
mitotically dividing layer of skin cells bound to the basement membrane |
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Term
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Definition
prickle cell layer, cells look spiny |
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Term
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Definition
thickest layer of epidermis in thin skin |
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Term
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Definition
polyhedral cells with prominent intercellular bridges(desmosomes), numerous cytoplasmic processes and lateral folding of the cell membrane to help anchor the cells tight |
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Term
cytokeratin, forms tonofilaments which aggregates into tonofibrils that anchor onto desmosomes |
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Definition
what is the predominant cell product of stratum spinosum, and what does it form? |
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Term
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Definition
characterized by cells containing basphillic keratohyaline granules |
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Term
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Definition
non-membrane bound electron dense granules |
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Term
keratinohyaline granules and tonofibrils |
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Definition
Keratinization of cells represents an interaction between _____ and ______ |
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Term
rupture of lysosomal granules |
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Definition
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|
Term
rupture of keratohyalin granules and polymerization of their contents |
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Definition
in keratinization, what does lysosomal granules rupturing cause? |
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Term
a matrix of tonofibrils of cytokeratin forms (rebar) which creates an amorphous mass of mature keratin |
|
Definition
in keratinization, what happens after the keratinohyaline granules rupture? |
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|
Term
when all the other junk ruptures, so do the lysosymes and the keratinocytes die and lose their nuclei |
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Definition
when mature keratin is made, what happens to the cells that made it? |
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Term
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Definition
contain glyoclipids, provide waterproofing coat for skin cells |
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Term
granular layer, yes membrane bound granules |
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Definition
where are lamellar bodies found? are the membrane bound? |
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Term
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Definition
cells of the granular layer mature to form a mature layer of keratinized cells with a ______ coating on the surface of the epidermis |
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Term
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Definition
layer only present in thick skin |
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Term
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Definition
homogenous, COMPACT layer of enucleate cells |
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Term
between stratum germinativum and stratum corneum |
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Definition
where is the stratum lucidum found |
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Term
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Definition
thickest layer of epidermis in thick skin |
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Term
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Definition
most superficial layer of skin, contains flattened, enucleate dead cell remnants, called squames |
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Term
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Definition
what is the stratum corneum composed of primarily |
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Term
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Definition
acts as a hydrophobic barrier and prevents dessication of the top layer of skin |
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Term
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Definition
another name for exfoliation |
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Term
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Definition
component of dandruff, house dust and bath tub rings |
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Term
exfoliated cervical epitheilal cells ->done to detect cervical cancer |
|
Definition
what is examined in pap smears? |
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|
Term
neuroectodermal (neural crest cells) -dendritic cells present in the epidermis |
|
Definition
what is the origin of melanocytes |
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Term
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Definition
where are melanocytes found? |
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|
Term
Morrow said in lab there might be 1 every 10 dermal papilla, relatively few |
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Definition
how common are melanocytes |
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Term
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Definition
where do the extensive cytoplasmic processes of melanocytes extend into? |
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Term
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Definition
responsible for production of melanin-skin pigment |
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|
Term
its released from the melanocytes (so they look pale) and taken up by surrounding epidermal cells |
|
Definition
what happens to melanin once it is made? |
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Term
|
Definition
what are the 2 types of melanin? |
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Term
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Definition
brown/black pigment found in dark haired individuals |
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Term
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Definition
red to yellow pigment found in individuals with red or blonde hair |
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Term
no, we just have variable rates of production and degradation by lysosomal enzymes
ex: light skinned produces less pigment or digest pigment faster. dark skinned people produce and retain more pigment longer |
|
Definition
do black people have more melanocytes than white people? explain. |
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Term
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Definition
autoimmune disease that causes destruction of melanocytes leading to depigmentation |
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|
Term
MSH (melanocyte stimulating hormone) a petuitary hormone |
|
Definition
what controls melanin synthesis |
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Term
|
Definition
what a.a. is the precursor melanin |
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Term
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Definition
tyrosine is oxidized to _______ by tyrosinase located in what organelles? |
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Term
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Definition
where is DOPA converted to melanin |
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Term
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Definition
in albanism, what enzyme is lacking? |
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Term
yes but they do not mature |
|
Definition
do premelanosomes form in albinos? |
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Term
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Definition
what can be used as a marker to differentiate melanocytes from keratinocytes containing phagocytosed melanin |
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Term
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Definition
what is used in distunguishing tumor types (melanoma vs squamous cell carcinoma) |
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|
Term
1) dna sunscreen, inhibits mutagenesis 2) uv exposure stimulates melanin synth =tanning 3) necessary for normal neural development |
|
Definition
what are the 3 reasons melanin is made? |
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|
Term
they are deaf, they don't have melanin to direct their neurons |
|
Definition
what is true about most cats with blue eyes? why? |
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Term
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Definition
fixed tissue macrophages, phagocytic antigen presenting cells |
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Term
Langerhans cells, looks like a tennis racket, not sure what they do :) |
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Definition
where are birbeck granules, where are they found? what do they do? |
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Term
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Definition
where are Langerhans cells located |
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Term
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Definition
involved in contact allergic dermatitis, contain abundant cytoplasmic extensions |
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Term
Langerhans cells, eats up pigment quite proud of itself (that is not phagocytized), then dies, barfs it up, and another one eats the pigment causing the tatoo to blur/fade |
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Definition
what cells are involved in tatooing? how? |
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Term
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Definition
embryological outgrowths of epidermis |
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Term
hair, nails, sebaceous glands, sweat glands, horns |
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Definition
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Term
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Definition
cyllindical downgrowth of epithelium surrounded by collagen sheats |
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Term
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Definition
what is the hair shaft produced by? |
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Term
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Definition
where does hair growth occur? |
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Term
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Definition
the deep terminal expansion of follicle |
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Term
actively dividing epithelial cells homologous to stratum basale |
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Definition
what lines the hair bulb? |
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Term
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Definition
what is the vascular core at the base of the bulb |
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|
Term
ridges that stick up into the epidermis, also the thing at the base of the hair shaft |
|
Definition
what is/are dermal papilla |
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Term
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Definition
the dermal papilla (on the hair shaft) is a finger like invagination of ____ containing blood vessels |
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Term
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Definition
in hair growth as the epithelial cells lining the hair bulb mature, they fill it with ______ arranged in parallel bundles |
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Term
hard k has more di-sulfide bonds and cross-linkages |
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Definition
what is the difference between hard and soft keratin? |
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Term
melanocytes nearby the hair follicle produce melanin which is incoporated into the cortex |
|
Definition
how do hair cells get pigment? |
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Term
outer cortex and inner medulla |
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Definition
what does the hair shaft consist of? (2 parts) |
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Term
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Definition
what covers the shaft of the hair, made of overlapping keratin plates to prevent matting |
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Term
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Definition
separates the hair bulb from surrounding dermis |
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Term
internal and external root sheath |
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Definition
developing hair is surrounded and protected by ______ and ______ which line the hair follicle |
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|
Term
decreased melanocyte production of melanin causes air bubbles in the hair shaft and separation of the fibers |
|
Definition
how do gray hairs happen? |
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|
Term
protection and thermoregulation |
|
Definition
what is the purpose of hair? |
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Term
|
Definition
where is hair not found on humans? |
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Term
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Definition
name for the growth phase of hair |
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Term
|
Definition
name for the resting phase of hair |
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Term
|
Definition
name for follicle atrophy |
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|
Term
dormant telogen follicles (they retired and went to Florida) |
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Definition
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|
Term
fine body hair in women and children, similar to soft undercoat in many mammals |
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Definition
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Term
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Definition
outer hair coat of most mammals is compose of this |
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Term
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Definition
in males at puberty, vellus hair is replaced by coarse _____ hairs similar to guard hairs or hair on scalp |
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Term
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Definition
most common form of hair loss, affecting 30-40% of adults--genetic and androgen dependent |
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Term
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Definition
affected individuals of androgenic allopecia have high levels of _______ the enzyme that converts testosterone to dihydroxytestosterone -> follicular atrophy |
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Term
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Definition
what shape are the hairs of people with: 1) straight hair 2) wavy hair 3) curly hair |
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Term
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Definition
bundles of smooth muscle cells that attach to hair follicle and sheath and insert on epidermal ridges |
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Term
piloerection-sympathetic stimulation due to cold/fear/aggression |
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Definition
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Term
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Definition
flattened nails are unique to ___ |
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Term
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Definition
nails consist of a _____ that rests on stratified squamous epithelium of nail bed |
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Term
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Definition
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Term
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Definition
part of nail that extends into dermis, attaches to periosteum of distal phalynx |
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Term
proliferation and differentiation at nail root in germinative zone of nail matrix |
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Definition
nail growth occurs by what mechanism? |
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Term
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Definition
underlies lunula, covered by superficial cuticle |
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Term
|
Definition
white crescent at base of nail |
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Term
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Definition
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Term
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Definition
as epithelial cells mature they fill with keratin and die, forming the ______ |
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Term
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Definition
nail plate consists of densely packed parallel _______ _____ filaments embedded in amorphous matrix |
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Term
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Definition
____ slides over the underlying nail bed as it grows |
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Term
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Definition
alveolar holocrine glands consisting of branched ascini |
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Term
outgrowths of the external root sheath |
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Definition
sebaceous glands are one or more glands associated with each hair follicle, they develop as _______ ___ ___ _______ _____ ____ |
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Term
sebum (high lipid content and cell debris-holocrine), pilosebaceous canal |
|
Definition
what do sebaceous glands secrete? what is the name of the duct? |
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|
Term
waterproofing, moisturizing skin and hair |
|
Definition
what is the function of sebaceous glands |
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|
Term
non-haired transitional skin (they secrete directly on skin surface) |
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Definition
where else are sebaceous glands found besides hairs? |
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|
Term
each hair follicle + associated arrector pili muscle + sebaceous gland |
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Definition
what makes up a pilosebaceous unit? |
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Term
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Definition
excess sebaceous gland sebum production |
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Term
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Definition
simpled, coiled tubular glands surrounded by myeloepithelial cells which assist in secretion |
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Term
merocrine/eccrine & apocrine |
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Definition
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|
Term
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Definition
people with good complexions have lots of ____ |
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Term
all over most of body surface, EXCEPT lips and genitalia |
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Definition
location of merocrine(eccrine) sweat glands |
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|
Term
merocrine(eccrine) sweat gland |
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Definition
unbranched, coiled, tubular glands with 1-2 layers of cuboidal to columnar epithelium with excretory ducts |
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Term
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Definition
this type of gland secretes only product |
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Term
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Definition
this type of gland secretes product and some cytoplasm |
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Term
sweat pore on epidermal ridge |
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Definition
sweat is secreted onto skin via a ____ ___ on ___ ____ |
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|
Term
hypotonic solution of salts, ammonia, urea, uric acid |
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Definition
what is in merocrine/eccrine sweat? |
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Term
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Definition
how much fluid is lost per day due to evaporation from lungs, skin, and mucous membranes |
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Term
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Definition
thermoregulatory sweating is (parasympathetic/cholinergic or sympathetic/adrenergic) |
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|
Term
axillae, forehead, scalp, last on hands and feet |
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Definition
where does thermoregulatory sweating first occur? last? |
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Term
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Definition
where does emotional sweating occur first? |
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Term
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Definition
emotional sweating is (parasympathetic/cholinergic or sympathetic/adrenergic) |
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Term
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Definition
coiled tubular gland with large dilated lumina. secretory cuboidal epithelium, 2-3 layers thick, surround large glandular lumen |
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Term
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Definition
gland located in axillae and groin, develop at puberty |
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|
Term
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Definition
discharge thick viscid secretions into hair follicle |
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|
Term
proteins, carbs, ammonia, lipids, and organic products |
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Definition
what is in apocrine sweat? |
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|
Term
yes when it's secreted, but bacterial breakdown makes the acrid odor |
|
Definition
is apocrine sweat odorless? |
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Term
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Definition
in mammals this serves as a sexual attractant pheremone used in scent marking and territoriality |
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Term
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Definition
apocrine glands are (parasymp/cholergenic or symp/adrenergic) |
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|
Term
external auditory meatus (ear canal) they are modified apocrine glands that secrete earwax |
|
Definition
where are ceruminous glands located? |
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Term
|
Definition
what animals did he mention have modified anal sweat glands? |
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|
Term
mammary ridges or milk lines |
|
Definition
mammary glands develop along paired epidermal ridges called _____ ___ which extend from the axillae to the groin |
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|
Term
only the first pair, in other mammals there are more |
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Definition
in humans what pair of glands along the milk line develops? |
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Term
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Definition
highly modified apocrine sweat glands identical in male and female until puberty |
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|
Term
in female, the pituitary and ovarian hormones cause them to develop and produce milk following pregnancy |
|
Definition
what causes mammary glands to develop? |
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|
Term
they atrophy and involute |
|
Definition
what happens to mammary glands at menopause? |
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|
Term
dense, irregular, collagenous connective tissue, interspersed with lobules of adipose tissue |
|
Definition
what is found in inactive glands? |
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|
Term
lactiferous ducts surrounded by myoepithelial cells which empty into lactiferous sinus in region of nipple |
|
Definition
what drains mammary glands? |
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|
Term
|
Definition
pigmented region of the epidermis surrounding the nipple |
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|
Term
stratified squamous epithelia with deep dermal ridges |
|
Definition
what type of epithelia is the areola? |
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|
Term
areolar glands: merocrine sweat and sebaceous glands |
|
Definition
type of glands found in the areola |
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|
Term
|
Definition
during _____ mammary glands enlarge due to hypertrophy of secretory cells and accumulation of secretory product |
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|
Term
colostrum-an alkalineyellowish scretion with high protein and salt, low lipid and carbohydrate
ALSO-large amount of antibodies, important in passive immunity tranfer to offspring |
|
Definition
what is secreted the first few days after birth and what is is composed of? |
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Term
|
Definition
is milk production merocrine or apocrine? |
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|
Term
protein-mostly merocrine lipid-mostly apocrine |
|
Definition
what glands does the protein part of milk come from? the lipid? |
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|
Term
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Definition
mechanoreceptors/touch receptors especially prominent in hands, feet, lips, genitalia (sensitive places) |
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|
Term
dermal ridges of papillary dermis |
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Definition
what layer of skin are meissner's corpuscles found? |
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Term
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Definition
afferent nerve fibers associated with minimally modified Schwann cells, cylindrical in shape |
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|
Term
large ovoid structures-mechanoreceptors , in dermis and hypodermis |
|
Definition
what are pascinian corpuscles, and where in the skin are they found? |
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|
Term
prominent in fingertips and around joints |
|
Definition
where in the body are pacinian corpuscles |
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Term
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Definition
detects mechanical and vibratory pressure |
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|
Term
|
Definition
consists of affent nerve fibers surrounded by highly modified Schwann cells-form coencentric lamellae separated by fluid filled spaces |
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|
Term
|
Definition
consists of affent nerve fibers surrounded by highly modified Schwann cells-form coencentric lamellae separated by fluid filled spaces |
|
|
Term
|
Definition
most numerous sensory receptors present in epidermis and papillary dermis-surrounds most hair follicles |
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|
Term
|
Definition
do free nerve endings have a CT capsule and/or schwann cells |
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|
Term
heat/cold, touch, pain, movement |
|
Definition
what things do free nerve ending sense? |
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|
Term
|
Definition
epidermal cells derived from nerual crest, located in stratum basale, contain dense core granules |
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|
Term
|
Definition
pressure sensitive mechanoreceptors associated with free afferent nerve endings |
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|
Term
healing from a clean, surgical approximated incision |
|
Definition
what is first intention healing? |
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|
Term
|
Definition
what happens to the incision immediately in first intention healing |
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|
Term
neutrofils infiltrate the clot |
|
Definition
what happens in 3-24 hours in first intention healing? |
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|
Term
24-48 hours, epithelial cells of stratum basale begin mitosis |
|
Definition
how long does it take for the epithelia to close(reapproximate)? how does it happen? |
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|
Term
neutrophils are replaced by macrophages (transition from acute to subacute phase) |
|
Definition
what happens in days 3-7 of first intention healing? |
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|
Term
1)neovascularization (blood vessel growth) 2) fibroplasia(fibroblasts come in with collagen) 3) re-epithelialization(epithelial proliferation & production of granulation tissue) |
|
Definition
in first intention healing, when the cells transition from acute to subacute phase what 3 processes occur? |
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|
Term
the incision is filled with granulation tissue |
|
Definition
what happens on day 5 of first intention healing? |
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|
Term
continued fibroplasia and collagen accumulation with decreased inflammation ->mature granulation tissue |
|
Definition
in week 2 of fist intention healing, what happens? |
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|
Term
week 2, presence of inflammatory cells and their cell products |
|
Definition
when do scabs start to itch and why? |
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|
Term
there is a CT scar without inflammation covered by intact epithelium |
|
Definition
what happens in month 2 of first intention healing? |
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|
Term
collagen breaks down and old scars can re-open and bleed |
|
Definition
what happens to scars with a vit. C deficiency? |
|
|
Term
|
Definition
occurs with more extensive loss of tissue where wound edges do not approximate (infarct, ulcer, abcess) |
|
|
Term
|
Definition
what is the rate of migration of epithelial cells of the stratum basale from the edge of the wound? |
|
|
Term
|
Definition
how long does it take to fill a 1cm wide cut? |
|
|
Term
haired skin->migration of cells from external root sheath of hair follicles |
|
Definition
what helps speed up re-epithelialization in second intention healing? |
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|
Term
|
Definition
in second intention healing, simultaneous proliferation/maturation of ______ behind migrating front slowly restores multilayered, stratified epidermis |
|
|
Term
|
Definition
how long does it take cells to mature from stratum basale to stratum corneum? |
|
|
Term
keratinization of new cells |
|
Definition
what causes desquamation and lifting of scab from the periphery (at 3 wks) |
|
|
Term
|
Definition
what causes wound contraction? |
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|
Term
|
Definition
in a full thickness abrasion or 3rd degree burns, re-epithelialization is limited by size of wound, ____ is generally necessary |
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Term
it clears blocked ducts/vessels and stimulates a second wave of migration, and new granulation tissue
also minimizes scarring |
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Definition
why is picking your scabs good? |
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Term
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Definition
disease where antibodies jack up antigens in hemidesmosomes in lamina lucida, causing separation of the dermis and epidermis ->blisters |
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Term
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Definition
benign accumulation of melanocytes in the dermis |
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Term
they are all things that assist with waterproofing skin |
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Definition
what do lamellar bodies, sebaceous glands, and keratinization have in common? |
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