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Skin and Adnexae
Morrow 2/14/11 lecture
219
Histology
Undergraduate 4
02/09/2011

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Cards

Term
1)protection
2)sensation
3)thermoregulation
4)metabolic functions
Definition
list the four main functions of skin
Term
Skin, 15-20%
Definition
what is the largest organ of the body and what percent body mass does it take up?
Term
epidermis, dermis, hypodermis (subcutis)
Definition
name the 3 layers of skin
Term
1)UV, 2)mechanical, 3) chemical, & 4)thermal insult. 5) Prevents dehydration 6) Barrier to microbes
Definition
what does skin protect against?
Term
skin
senses:
pressure
pain
and temperature
Definition
what is the largest sense organ in the body, what does it sense?
Term
insulation via Sub Q fat
heat loss facilitated by sweat glands & dermal capillary network
Definition
how does skin thermoregulate?
Term
energy stored in subQfat (triglycerides)
Vitamin D synth'd in skin with sunlight
maintains homeostasis
excretory fxn: sweating
immune defense
Definition
what are the metabolic functions of skin?
Term
Epidermis
Definition
consists of keratinized, stratified squamous epithelium
Term
keratinocytes
Definition
normal epidermis cells called this
Term
thickness of EPIdermis, not all 3 layers
Definition
what does thick/thin skin depend on?
Term
<1mm to 5mm
Definition
what range can skin vary in thickness from?
Term
volar soles, and palmar surfaces
Definition
where is thick skin found
Term
No
Definition
does thick skin have hair?
Term
keratinized
Definition
thick skin has a thick highly _____ layer
Term
thin, thin
Definition
most of the body is covered in _____(thick/thin) skin with _____ keratinized epidermis
Term
no
Definition
are there blood vessels in the epidermis or its basement membrane?
Term
no
Definition
are there blood vessels in the epidermis or its basement membrane?
Term
dermis (supplies the epidermis) & hypodermis
Definition
what layer are the blood vessels found in skin?
Term
dermis
Definition
layer of skin composed of dense irregular collagenous connective tissue interspersed with elastic fibers
Term
Type 1
Definition
what type of collagen is found in the dermis
Term
dermis
Definition
progressive damage to elastic fibers in this layer(from sunlight) causes aging and loss of skin tone
Term
dermis
Definition
highly vascular layer of skin with many sensory receptors
Term
papillary layer, deep reticular layer
Definition
name the 2 layers of the dermis
Term
papillary layer
Definition
relatively thin layer that interdigitates with the epidermis corrugations increase surface area for attachement and prevent shear and mechanical abrasion
Term
epidermal (rete) ridges
Definition
epidermal projections into dermis
Term
dermal ridges/papillae
Definition
dermal projections into the epidermis
Term
fingerprints
Definition
large dermal ridges in thick skin
Term
dermatoglyphics
Definition
what is the name of the study of fingerprints?
Term
reticular layer
Definition
thicker and less cellular layer of dermis
Term
reticular layer of dermis
Definition
what layer of the skin contains hair follicles, sweat, and sebaceous glands?
Term
Langer's lines
Definition
thick collagen bundles and elastin fibers in reticular layer form lines of tension called ____
Term
incisions made parallel to the lines cut between the collagen bundles and leave less scarring when they heal
Definition
what is clinically significant about Langer's lines?
Term
subpapillary plexi, cutaneous plexi, subcutaneous plexi
Definition
name the 3 vascular plexi in skin
Term
subpap-at junction or papillary and reticular dermis

cut-located at junction of reticular layer and hypodermis

sub Q-deep in hypodermis
Definition
where are the subpapillary plexi, cutaneous plexi, and subcutaneous plexi found?
Term
subcutaneous plexi, fingertips and ears
Definition
which vascular plexi of the skin is used in thermoregulation, and where in the body?
Term
glomus bodies
Definition
thickened regions of smooth muscle in wall of arterioles surrounded by CT capsule
Term
re-route blood from atrial to venous circulation by bypassing the capillary bed

=AV shunt
Definition
what do glomus bodies do?
Term
hypodermis
Definition
layer of loose, irregular CT and adipose
Term
subcutis, superficial fascia, panniculus adiposus
Definition
other names for the hypodermis
Term
25-50 days
Definition
how long does it take a skin cell to travel from the deep germinal layer, mature, and be sloughed off(desquamated)?
Term
psoriasis
Definition
what disease causes immature, irregular keratinocytes that mature in only 1 wk
Term
absence of a granular layer, abnormal keratohyaline and tonofibrils
Definition
in psoriasis, besides the lifespan of the skin cells, what is irregular about them?
Term
cuboidal
Definition
what shape are the cells of the stratum basale?
Term
BM: hemidesmosomes
dermis: anchoring filaments and microfibrils
Definition
how is the stratum germinativum anchored to the basement membrane? the dermis?
Term
stratum basale/germinativum
Definition
mitotically dividing layer of skin cells bound to the basement membrane
Term
stratum spinosum
Definition
prickle cell layer, cells look spiny
Term
stratum spinosum
Definition
thickest layer of epidermis in thin skin
Term
stratum spinosum cells
Definition
polyhedral cells with prominent intercellular bridges(desmosomes), numerous cytoplasmic processes and lateral folding of the cell membrane to help anchor the cells tight
Term
cytokeratin, forms tonofilaments which aggregates into tonofibrils that anchor onto desmosomes
Definition
what is the predominant cell product of stratum spinosum, and what does it form?
Term
stratum granulosum
Definition
characterized by cells containing basphillic keratohyaline granules
Term
keratohyaline granules
Definition
non-membrane bound electron dense granules
Term
keratinohyaline granules and tonofibrils
Definition
Keratinization of cells represents an interaction between _____ and ______
Term
rupture of lysosomal granules
Definition
initiates keratinization
Term
rupture of keratohyalin granules and polymerization of their contents
Definition
in keratinization, what does lysosomal granules rupturing cause?
Term
a matrix of tonofibrils of cytokeratin forms (rebar) which creates an amorphous mass of mature keratin
Definition
in keratinization, what happens after the keratinohyaline granules rupture?
Term
when all the other junk ruptures, so do the lysosymes and the keratinocytes die and lose their nuclei
Definition
when mature keratin is made, what happens to the cells that made it?
Term
lamellar bodies
Definition
contain glyoclipids, provide waterproofing coat for skin cells
Term
granular layer, yes membrane bound granules
Definition
where are lamellar bodies found? are the membrane bound?
Term
glycolipid
Definition
cells of the granular layer mature to form a mature layer of keratinized cells with a ______ coating on the surface of the epidermis
Term
stratum lucidum
Definition
layer only present in thick skin
Term
stratum lucidum
Definition
homogenous, COMPACT layer of enucleate cells
Term
between stratum germinativum and stratum corneum
Definition
where is the stratum lucidum found
Term
stratum corneum
Definition
thickest layer of epidermis in thick skin
Term
stratum corneum
Definition
most superficial layer of skin, contains flattened, enucleate dead cell remnants, called squames
Term
soft keratin
Definition
what is the stratum corneum composed of primarily
Term
soft keratin
Definition
acts as a hydrophobic barrier and prevents dessication of the top layer of skin
Term
desquamation
Definition
another name for exfoliation
Term
dead skin cells
Definition
component of dandruff, house dust and bath tub rings
Term
exfoliated cervical epitheilal cells ->done to detect cervical cancer
Definition
what is examined in pap smears?
Term
neuroectodermal (neural crest cells)
-dendritic cells present in the epidermis
Definition
what is the origin of melanocytes
Term
usually the basal layer
Definition
where are melanocytes found?
Term
Morrow said in lab there might be 1 every 10 dermal papilla, relatively few
Definition
how common are melanocytes
Term
stratum spinosum
Definition
where do the extensive cytoplasmic processes of melanocytes extend into?
Term
melanocytes
Definition
responsible for production of melanin-skin pigment
Term
its released from the melanocytes (so they look pale) and taken up by surrounding epidermal cells
Definition
what happens to melanin once it is made?
Term
eumalanin, pheomelanin
Definition
what are the 2 types of melanin?
Term
eumalanin
Definition
brown/black pigment found in dark haired individuals
Term
pheomelanin
Definition
red to yellow pigment found in individuals with red or blonde hair
Term
no, we just have variable rates of production and degradation by lysosomal enzymes

ex: light skinned produces less pigment or digest pigment faster.
dark skinned people produce and retain more pigment longer
Definition
do black people have more melanocytes than white people? explain.
Term
vitiligo
Definition
autoimmune disease that causes destruction of melanocytes leading to depigmentation
Term
MSH (melanocyte stimulating hormone) a petuitary hormone
Definition
what controls melanin synthesis
Term
tyrosine
Definition
what a.a. is the precursor melanin
Term
DOPA, in premelanosomes
Definition
tyrosine is oxidized to _______ by tyrosinase located in what organelles?
Term
melanosomes
Definition
where is DOPA converted to melanin
Term
tyrosinase
Definition
in albanism, what enzyme is lacking?
Term
yes but they do not mature
Definition
do premelanosomes form in albinos?
Term
tyrosinase
Definition
what can be used as a marker to differentiate melanocytes from keratinocytes containing phagocytosed melanin
Term
tyrosinase
Definition
what is used in distunguishing tumor types (melanoma vs squamous cell carcinoma)
Term
1) dna sunscreen, inhibits mutagenesis
2) uv exposure stimulates melanin synth =tanning
3) necessary for normal neural development
Definition
what are the 3 reasons melanin is made?
Term
they are deaf, they don't have melanin to direct their neurons
Definition
what is true about most cats with blue eyes? why?
Term
Langerhans cells
Definition
fixed tissue macrophages, phagocytic antigen presenting cells
Term
Langerhans cells, looks like a tennis racket, not sure what they do :)
Definition
where are birbeck granules, where are they found? what do they do?
Term
stratum spinosum
Definition
where are Langerhans cells located
Term
Langerhans cells
Definition
involved in contact allergic dermatitis, contain abundant cytoplasmic extensions
Term
Langerhans cells, eats up pigment quite proud of itself (that is not phagocytized), then dies, barfs it up, and another one eats the pigment causing the tatoo to blur/fade
Definition
what cells are involved in tatooing? how?
Term
skin appendages
Definition
embryological outgrowths of epidermis
Term
hair, nails, sebaceous glands, sweat glands, horns
Definition
list the skin appendages
Term
follicle
Definition
cyllindical downgrowth of epithelium surrounded by collagen sheats
Term
hair follicles
Definition
what is the hair shaft produced by?
Term
the hair bulb/root
Definition
where does hair growth occur?
Term
hair bulb/root
Definition
the deep terminal expansion of follicle
Term
actively dividing epithelial cells homologous to stratum basale
Definition
what lines the hair bulb?
Term
dermal papilla
Definition
what is the vascular core at the base of the bulb
Term
ridges that stick up into the epidermis, also the thing at the base of the hair shaft
Definition
what is/are dermal papilla
Term
dermis
Definition
the dermal papilla (on the hair shaft) is a finger like invagination of ____ containing blood vessels
Term
keratin filaments
Definition
in hair growth as the epithelial cells lining the hair bulb mature, they fill it with ______ arranged in parallel bundles
Term
hard k has more di-sulfide bonds and cross-linkages
Definition
what is the difference between hard and soft keratin?
Term
melanocytes nearby the hair follicle produce melanin which is incoporated into the cortex
Definition
how do hair cells get pigment?
Term
outer cortex and inner medulla
Definition
what does the hair shaft consist of? (2 parts)
Term
cuticle
Definition
what covers the shaft of the hair, made of overlapping keratin plates to prevent matting
Term
glassy membrane
Definition
separates the hair bulb from surrounding dermis
Term
internal and external root sheath
Definition
developing hair is surrounded and protected by ______ and ______ which line the hair follicle
Term
decreased melanocyte production of melanin causes air bubbles in the hair shaft and separation of the fibers
Definition
how do gray hairs happen?
Term
protection and thermoregulation
Definition
what is the purpose of hair?
Term
skin of palms and soles
Definition
where is hair not found on humans?
Term
anagen
Definition
name for the growth phase of hair
Term
catagen
Definition
name for the resting phase of hair
Term
telogen
Definition
name for follicle atrophy
Term
dormant telogen follicles (they retired and went to Florida)
Definition
what are club hairs?
Term
fine body hair in women and children, similar to soft undercoat in many mammals
Definition
what is vellus hair?
Term
guard hairs
Definition
outer hair coat of most mammals is compose of this
Term
terminal
Definition
in males at puberty, vellus hair is replaced by coarse _____ hairs similar to guard hairs or hair on scalp
Term
androgenic alopecia
Definition
most common form of hair loss, affecting 30-40% of adults--genetic and androgen dependent
Term
5-alpha-reductase
Definition
affected individuals of androgenic allopecia have high levels of _______ the enzyme that converts testosterone to dihydroxytestosterone -> follicular atrophy
Term
1)round
2)oval
3)flat
Definition
what shape are the hairs of people with:
1) straight hair
2) wavy hair
3) curly hair
Term
arrector pili
Definition
bundles of smooth muscle cells that attach to hair follicle and sheath and insert on epidermal ridges
Term
piloerection-sympathetic stimulation due to cold/fear/aggression
Definition
what causes goosebumps?
Term
primates
Definition
flattened nails are unique to ___
Term
flattened nail plate
Definition
nails consist of a _____ that rests on stratified squamous epithelium of nail bed
Term
nail root
Definition
proximal end of nail
Term
nail root
Definition
part of nail that extends into dermis, attaches to periosteum of distal phalynx
Term
proliferation and differentiation at nail root in germinative zone of nail matrix
Definition
nail growth occurs by what mechanism?
Term
nail matrix
Definition
underlies lunula, covered by superficial cuticle
Term
lunula
Definition
white crescent at base of nail
Term
eponychium
Definition
another name for cuticle
Term
nail plate
Definition
as epithelial cells mature they fill with keratin and die, forming the ______
Term
hard keratin
Definition
nail plate consists of densely packed parallel _______ _____ filaments embedded in amorphous matrix
Term
nail plate
Definition
____ slides over the underlying nail bed as it grows
Term
sebaceous glands
Definition
alveolar holocrine glands consisting of branched ascini
Term
outgrowths of the external root sheath
Definition
sebaceous glands are one or more glands associated with each hair follicle, they develop as _______ ___ ___ _______ _____ ____
Term
sebum (high lipid content and cell debris-holocrine), pilosebaceous canal
Definition
what do sebaceous glands secrete? what is the name of the duct?
Term
waterproofing, moisturizing skin and hair
Definition
what is the function of sebaceous glands
Term
non-haired transitional skin (they secrete directly on skin surface)
Definition
where else are sebaceous glands found besides hairs?
Term
each hair follicle + associated arrector pili muscle + sebaceous gland
Definition
what makes up a pilosebaceous unit?
Term
sebhorrea
Definition
excess sebaceous gland sebum production
Term
sweat glands
Definition
simpled, coiled tubular glands surrounded by myeloepithelial cells which assist in secretion
Term
merocrine/eccrine & apocrine
Definition
2 types of sweat glands
Term
follicle mites
Definition
people with good complexions have lots of ____
Term
all over most of body surface, EXCEPT lips and genitalia
Definition
location of merocrine(eccrine) sweat glands
Term
merocrine(eccrine) sweat gland
Definition
unbranched, coiled, tubular glands with 1-2 layers of cuboidal to columnar epithelium with excretory ducts
Term
merocrine/eccrine
Definition
this type of gland secretes only product
Term
apocrine
Definition
this type of gland secretes product and some cytoplasm
Term
sweat pore on epidermal ridge
Definition
sweat is secreted onto skin via a ____ ___ on ___ ____
Term
hypotonic solution of salts, ammonia, urea, uric acid
Definition
what is in merocrine/eccrine sweat?
Term
600ml/day
Definition
how much fluid is lost per day due to evaporation from lungs, skin, and mucous membranes
Term
parasympathetic
Definition
thermoregulatory sweating is (parasympathetic/cholinergic or sympathetic/adrenergic)
Term
axillae, forehead, scalp, last on hands and feet
Definition
where does thermoregulatory sweating first occur? last?
Term
palms and soles
Definition
where does emotional sweating occur first?
Term
sympathetic
Definition
emotional sweating is (parasympathetic/cholinergic or sympathetic/adrenergic)
Term
apocrine sweat gland
Definition
coiled tubular gland with large dilated lumina. secretory cuboidal epithelium, 2-3 layers thick, surround large glandular lumen
Term
apocrine sweat glands
Definition
gland located in axillae and groin, develop at puberty
Term
apocrine glands
Definition
discharge thick viscid secretions into hair follicle
Term
proteins, carbs, ammonia, lipids, and organic products
Definition
what is in apocrine sweat?
Term
yes when it's secreted, but bacterial breakdown makes the acrid odor
Definition
is apocrine sweat odorless?
Term
apocrine sweat
Definition
in mammals this serves as a sexual attractant pheremone used in scent marking and territoriality
Term
adrenergic, sympathetic
Definition
apocrine glands are (parasymp/cholergenic or symp/adrenergic)
Term
external auditory meatus (ear canal) they are modified apocrine glands that secrete earwax
Definition
where are ceruminous glands located?
Term
dogs, deer, skunks
Definition
what animals did he mention have modified anal sweat glands?
Term
mammary ridges or milk lines
Definition
mammary glands develop along paired epidermal ridges called _____ ___ which extend from the axillae to the groin
Term
only the first pair, in other mammals there are more
Definition
in humans what pair of glands along the milk line develops?
Term
mammary glands
Definition
highly modified apocrine sweat glands identical in male and female until puberty
Term
in female, the pituitary and ovarian hormones cause them to develop and produce milk following pregnancy
Definition
what causes mammary glands to develop?
Term
they atrophy and involute
Definition
what happens to mammary glands at menopause?
Term
dense, irregular, collagenous connective tissue, interspersed with lobules of adipose tissue
Definition
what is found in inactive glands?
Term
lactiferous ducts surrounded by myoepithelial cells which empty into lactiferous sinus in region of nipple
Definition
what drains mammary glands?
Term
areola
Definition
pigmented region of the epidermis surrounding the nipple
Term
stratified squamous epithelia with deep dermal ridges
Definition
what type of epithelia is the areola?
Term
areolar glands: merocrine sweat and sebaceous glands
Definition
type of glands found in the areola
Term
lactation
Definition
during _____ mammary glands enlarge due to hypertrophy of secretory cells and accumulation of secretory product
Term
colostrum-an alkalineyellowish scretion with high protein and salt, low lipid and carbohydrate

ALSO-large amount of antibodies, important in passive immunity tranfer to offspring
Definition
what is secreted the first few days after birth and what is is composed of?
Term
both!
Definition
is milk production merocrine or apocrine?
Term
protein-mostly merocrine
lipid-mostly apocrine
Definition
what glands does the protein part of milk come from? the lipid?
Term
Meissener's corpuscles
Definition
mechanoreceptors/touch receptors especially prominent in hands, feet, lips, genitalia (sensitive places)
Term
dermal ridges of papillary dermis
Definition
what layer of skin are meissner's corpuscles found?
Term
meissener's corpuscles
Definition
afferent nerve fibers associated with minimally modified Schwann cells, cylindrical in shape
Term
large ovoid structures-mechanoreceptors , in dermis and hypodermis
Definition
what are pascinian corpuscles, and where in the skin are they found?
Term
prominent in fingertips and around joints
Definition
where in the body are pacinian corpuscles
Term
pacinian corpuscles
Definition
detects mechanical and vibratory pressure
Term
pacinian corpuscles
Definition
consists of affent nerve fibers surrounded by highly modified Schwann cells-form coencentric lamellae separated by fluid filled spaces
Term
pacinian corpuscles
Definition
consists of affent nerve fibers surrounded by highly modified Schwann cells-form coencentric lamellae separated by fluid filled spaces
Term
free nerve endings
Definition
most numerous sensory receptors present in epidermis and papillary dermis-surrounds most hair follicles
Term
no
Definition
do free nerve endings have a CT capsule and/or schwann cells
Term
heat/cold, touch, pain, movement
Definition
what things do free nerve ending sense?
Term
Merkel cells
Definition
epidermal cells derived from nerual crest, located in stratum basale, contain dense core granules
Term
Merkel cells
Definition
pressure sensitive mechanoreceptors associated with free afferent nerve endings
Term
healing from a clean, surgical approximated incision
Definition
what is first intention healing?
Term
blood clots fill it
Definition
what happens to the incision immediately in first intention healing
Term
neutrofils infiltrate the clot
Definition
what happens in 3-24 hours in first intention healing?
Term
24-48 hours, epithelial cells of stratum basale begin mitosis
Definition
how long does it take for the epithelia to close(reapproximate)? how does it happen?
Term
neutrophils are replaced by macrophages (transition from acute to subacute phase)
Definition
what happens in days 3-7 of first intention healing?
Term
1)neovascularization (blood vessel growth)
2) fibroplasia(fibroblasts come in with collagen)
3) re-epithelialization(epithelial proliferation & production of granulation tissue)
Definition
in first intention healing, when the cells transition from acute to subacute phase what 3 processes occur?
Term
the incision is filled with granulation tissue
Definition
what happens on day 5 of first intention healing?
Term
continued fibroplasia and collagen accumulation with decreased inflammation ->mature granulation tissue
Definition
in week 2 of fist intention healing, what happens?
Term
week 2, presence of inflammatory cells and their cell products
Definition
when do scabs start to itch and why?
Term
there is a CT scar without inflammation covered by intact epithelium
Definition
what happens in month 2 of first intention healing?
Term
collagen breaks down and old scars can re-open and bleed
Definition
what happens to scars with a vit. C deficiency?
Term
second intention healing
Definition
occurs with more extensive loss of tissue where wound edges do not approximate (infarct, ulcer, abcess)
Term
0.5 mm/day
Definition
what is the rate of migration of epithelial cells of the stratum basale from the edge of the wound?
Term
3 weeks
Definition
how long does it take to fill a 1cm wide cut?
Term
haired skin->migration of cells from external root sheath of hair follicles
Definition
what helps speed up re-epithelialization in second intention healing?
Term
keratinocytes
Definition
in second intention healing, simultaneous proliferation/maturation of ______ behind migrating front slowly restores multilayered, stratified epidermis
Term
25 days
Definition
how long does it take cells to mature from stratum basale to stratum corneum?
Term
keratinization of new cells
Definition
what causes desquamation and lifting of scab from the periphery (at 3 wks)
Term
myofibroblasts
Definition
what causes wound contraction?
Term
grafting
Definition
in a full thickness abrasion or 3rd degree burns, re-epithelialization is limited by size of wound, ____ is generally necessary
Term
it clears blocked ducts/vessels and stimulates a second wave of migration, and new granulation tissue

also minimizes scarring
Definition
why is picking your scabs good?
Term
bullous pemphigoid
Definition
disease where antibodies jack up antigens in hemidesmosomes in lamina lucida, causing separation of the dermis and epidermis ->blisters
Term
moles or naevi
Definition
benign accumulation of melanocytes in the dermis
Term
they are all things that assist with waterproofing skin
Definition
what do lamellar bodies, sebaceous glands, and keratinization have in common?
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