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SGU Pharmacology
Antimicrobials - Penicillins Part 2
7
Medical
Professional
08/29/2010

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Term
Penicillin G
Definition
Natural, not gastric stable, used against gm+ve and -ve cocci, gm+ve bacilli, spirochetes + anaerobes
Term
Penicillin G benzathine
Definition
Natural, IM, T 1/2 3-4 wks, painful at injection site, Tx: syphilis, rheumatic fever prophylaxis, streptococcal pharyngitis
Term
Penicillin G procaine
Definition
Natural, IM not IV (risk of procaine toxicity), T 1/2 12-24 hrs, seldom used
Term
Penicillin V
Definition
Natural, given orally, higher MBC (less potent)
Term
Dicloxacillin, Methicillin, Nafcillin, Oxacillin
Definition
Antistaph, penicillinase resistant
Term
Carbenicillin, Piperacillin (most potent), Ticarcillin
Definition
Antipseudomonal, active against P. aeruginosa, effective against many gm-ve bacilli, combined w/ beta-lactamase inhibitor
Term
Amoxicillin & Ampicillin
Definition
Extended-Spectrum, similar to penicillin G, more effective against gm-ve bacilli, Ampicillin is the Rx of choice for Listeria monocytogenes (gm+ve bacilli), widely used to Tx RTs, plasmid mediated resistance is a big prob, combined w/ beta-lactamase inhibitor
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