Term
| Outline the Cholinergic Rxs? |
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Definition
Agonists - have direct acting and indirect (AchE inhibitors, NOTE the Reactivator of AChE) acting agonists.
Antagonists - are divided into muscarinic antagonists, ganglion blockers & neuromuscular blockers. Also NB the Rxs that act presynaptically |
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Term
| Outline the Adrenergic Rxs? |
|
Definition
Agonists - Direct acting (includes the endogenous catecholamines, general & specific for each receptor, also NOTE the D1 agonist), indirect acting & mixed axn
Antagonists - include the general and specific ones for each receptor, mixed ones and partial agonists (YES agonist!!!). NB that Rxs that act presynaptically |
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Term
| Cholinergic agonists - Direct acting |
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Definition
Acetylcholine
Bethanechol
Carbachol
Methacholine
Muscarine
Arecoline
Pilocarpine
Nicotine
Tetramethylammonium
DMPP
Varenicline |
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Term
| Cholinergic agonists - Indirect acting (AchE Inhibitors) |
|
Definition
Edrophonium
Physostigmine
Neostigmine
Pyridostigmine
Echothiophate
Malathion
Parathion
Tabun
Sarin
Soman
Tacrine
Donepezil
Rivastigmine
Galantamine |
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Term
| What is the Rx that reactivates AchE, and what is meant by aging? |
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Definition
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Term
| Cholinergic Antagonists - Muscarinic Antagonists |
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Definition
Atropine
Scopolamine
Ipratropium
Tiotropium
Homatropine
Cyclopentolate
Tropicamide
Benztropine
Trihexyphenidyl
Glycopyrrolate
Tolterodine |
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Term
| Cholinergic Antagonists - Ganglion Blockers |
|
Definition
Mecamylamine
Trimetaphan
Hexamethonium |
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Term
| Cholinergic Antagonists - Neuromuscular blockers |
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Definition
Tubocurarine
Succinylcholine |
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Term
| What are the cholinergic Rxs that act presynaptically? |
|
Definition
Hemicholinium
Vesamicol
Botulinum Toxin |
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Term
| Adrenergic Agonist - Direct acting |
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Definition
Endogenous catecholamines: Epinephrine,
Norepinephrine, Dopamine
D1 Agonists: Fenoldopam
α-agonists: Oxymethazoline
α1-agonists: Phenylephrine, Naphazoline, Xylomethazoline
α2-agonists: Clonidine, Methyldopa, Brimonidine
β-Agonists: Isoproterenol
β1-Agonists: Dobutamine
β2-agonists: Terbutaline, Albuterol, Salmeterol, Formoterol |
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Term
| Adrenergic Agonist - Indirect acting |
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Definition
Amphetamine
Methylphenidate
Tyramine |
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Term
| Adrenergic Agonist - Mixed axn |
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Definition
|
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Term
| Adrenergic Antagonists - General & Specific |
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Definition
α-antagonists: Phenoxybenzamine, Phentolamine
α1-antagonists: Prazosin, Terazosin, Doxazosin, Tamsulosin
α2-antagonists: Yohimbine
β-antagonists: Propranolol, Nadolol, Timolol
β1-antagonists: Atenolol, Metoprolol, Esmolol |
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Term
| Adrenergic Antagonists - Mixed axn |
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Definition
α1 & β-antagonists
Labetalol
Carvedilol |
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Term
| Adrenergic Antagonists - Partial Agonist |
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Definition
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Term
| What are the adrenergic Rxs that act presynaptically? |
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Definition
α-methyltyrosine
Reserpine
Guanethidine
Cocaine |
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