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SGU Immuno Vocab 4
SGU Immunology vocab list 4 Fall 2009
29
Health Care
Graduate
10/05/2009

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Term
AB system
Definition
Blood group polysaccaride antigens
Term
Affinity
Definition
The force between molecules that impels them to bind to one another (NON-COVALENT)
Term
Allotype
Definition
Antigenic differences within a given class of Ig
between members of the same species
Term
Allotypic
Definition
Pertaining to an allotype
(duh!)
Term
Am
Definition
The IgA allotypes
Term
Anti-idiotypeic antibodies
Definition
Antibodies that are specific for a set of idiotopes
Term
Avidity
Definition
The sum of the affinities when two molecules are interacting
Term
Class of antibody
Definition
Antibody isotypes
Term
Complemantary determing region (CDR)
Definition
That part of the variable region which is HYPERVARIABLE between antibodies
Term
Constant Region
Definition
That art of the Ab molecule that is the same for all Ab of one class within an isotype
Term
Crossreactive
Definition
Refers to the fact that some antibodies will bind to antigens that are closely related
Term
Gm
Definition
The IgG allotypes
Term
half-life
Definition
The period during which the number of antibody molecules is halved
Term
HAMA
(Human Anti-Mouse Antibodies)
Definition
Human responses to mouse antibodies injected for theraputic value
Term
Hybridoma
Definition
Cell that is the result of fusion of a tumor cell with a normal cell
Term
Idiotope
Definition
One component within the antibody hypervariable region that is unique
Term
Idiotype
Definition
The sum of the idiotopes
Term
Isohemagglutinin
Definition
IgM

antibodies that are specific for the A, B antigens on red blood cells
Term
J-chain
Definition
Th joining chains of the IgM and IgA antibodies
Term
Kappa
Definition
One of the two LIGHT CHAIN antibody CONSTANT regions (the other is lambda)
Term
Km
Definition
The kappa chain allotypes
Term
Lambda
Definition
One of the two LIGHT chain antibody CONSTANT regions (the other is lambda)
Term
Papain
Definition
an enzyme that cleaves the IgG antibody molecule ABOVE the disulfide bond
Term
Pepsin
Definition
An enzyme that cleaves the IgG antibody molecule BELOW the disulfide bond
Term
Proteolysis
Definition
Cleavage of proteins by enzymes
Term
Reaginic
Definition
Related to allergies and IgE antibodies
Term
Secretory component
Definition
The component of the IgA dimer that is retained when dimeric IgA is secreted into the lumen
Term
Subclass
Definition
Subclass within the class of antibodies (e.g. IgG1, IgG2, IgG3, IgG4)
Term
Variable region
Definition
The region of antibodies that varies from one antibody to another, even within one class
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