Term
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Definition
| A molecule on one cell surface that interacts with a counter molecule on another cell causing cells to ADHERE together |
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Term
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Definition
| Compliment protein fragments that bind receptors on MAST CELLS adn BASOPHILS causing their DEGRANULATION (Histamine release) |
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Term
| Antibody-dependent cell-mediated cytotoxicity (ADCC) |
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Definition
| Destruction of cells by natural killer cells followign interaction with the Fc regtion of IgG bound to the cell or microbe |
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Term
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Definition
| CIRCULATING cells that degranulate: counterpart of mast cells |
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Term
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Definition
| An inflammatory protien that acts as an OPSONIN. Secreted by HEPATOCYTES followin stimulation wiht IL-6 |
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Term
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Definition
| A COMPLIMENT protien that is central to BOTH the ALTERNATIVE and CLASSICAL pathways of compliment |
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Term
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Definition
| A proteolytic fragment of compliment - functions as an ANAPHYLATOXIN |
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Term
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Definition
| A proteolytic fragment of compliment - functions as an OPSONIN |
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Term
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Definition
| A proteolytic fragment of compliment - functions as an ANAPHYLATOXIN |
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Term
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Definition
| Molecules that serve to attract cells expressing COGNATE RECEPTORS on the cell surface |
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Term
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Definition
| Molecules that serve to attract cells expressing their cognate receptors on the cell receptors on the cell surface (e.g. chemokines) |
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Term
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Definition
| An ion that plays a role in host defense in the presence of HYDROGEN PEROXIDE |
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Term
| Chronic granulomatuous disease (clinical) |
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Definition
| A GENETIC disorder that results in an INABILITY TO DESTROY ANTIGEN IN THE PHAGOSOME |
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Term
| Diapedesis (inflammation) |
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Definition
| The process of moving from the blood vessel into a tissue |
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Term
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Definition
| Cells that play an important role in host immunity to HELMINTHS |
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Term
| Eosinophil cationic protien (ECP) |
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Definition
| Protien secreted by EOSINOPHILS - toxic to HELMINTHS |
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Term
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Definition
| RECEPTOR for IgE Fc region |
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Term
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Definition
| Receptor for IgG Fc region |
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Term
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Definition
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Term
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Definition
| molecule produced in the phagosome during biochemical cascade that follows activation of NADPH oxidase |
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Term
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Definition
| One of the reactive oxygen intermediates (ROI) produced following the activation of NADPH oxidase; play a role in destruction of microbes in the PHAGOSOME |
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Term
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Definition
| One of the reactive oxygen intermediates (ROI) produced following the activation of NADPH oxidase; play a role in destruction of microbes in the PHAGOSOME |
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Term
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Definition
| formed following interaction of hydrogen peroxide, chloride ion, proton: catalyzed by MYELOPEROXIDASE |
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Term
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Definition
| Antibody that plays a role in host defense to HELMINTHS (and allergies) Activate MAST CELLS: Prime 'em for degranulation when IgE binds to antigen |
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Term
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Definition
| Antiboy that plays important role in ADCC by NK cells and opsonin mediated phagocytosis by phagocytes. Can pass PLACENTAL BARRIER: half life about one day |
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Term
| Inducible nitric oxide synthase (iNOS) |
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Definition
| ENZYME that requires IFN(gamma)for its induction - enzyme required for the generation of NO in phagocytes |
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Term
| Interferon Gamma (IFNgamma) |
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Definition
| CYTOKINE that is secreted by HELPER T CELLS (CD4+Th1) |
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Term
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Definition
| Cytokine that is INHIBITORY for antigen presentin cell secretion of cytokines (e.g. IL-2) |
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Term
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Definition
| Cytokine that plays important role in switch from IgM to IgE antibodies on B cells |
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Term
| NK cell killer inhibitory receptors (KIR) |
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Definition
| NK cell receptors whose dominant interaction with thier cell ligands results in the PROTECTION of the cell |
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Term
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Definition
| Enzymes present in LYSOSIMES |
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Term
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Definition
| Cytoplasmic organelles that contain ENZYMES |
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Term
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Definition
| Tissue PHAGOCYTES: differentiated MONOCYTES |
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Term
| Major basic protien (MBP) |
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Definition
| Protien that is toxic to HELMINTHS: secreted by EOSINOPHILS |
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Term
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Definition
TISSUE cell that DEGRANULATES when ligand binds to receptors on the cell -
Tissue counterpart of basophils |
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Term
Membrane Attack Complex
(MAC) |
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Definition
| Complex of compliment protiens whose insertion into a cell or bacerium causes its OSMOTIC LYSIS |
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Term
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Definition
Enzyme required to initiate a cascade of biochemical changes that results in the production of
REACTIVE OXYGEN INTERMEDIATES
(ROIs) |
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Term
Natural Killer Cells
(NK cells) |
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Definition
| Cells of INNATE immunity that kill VIRALLY infected cells (and sometimes tumor cells) |
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Term
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Definition
| PHAGOCYTES that CIRCULATE. They ENTER TISSUES where there is inflammation |
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Term
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Definition
| Molecule that is toxic to microbes. It is produced following the induction of iNOS |
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Term
Nitroblue Tetrazolium Test
(NBT) |
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Definition
| A test that is performed to tell whether the NADPH oxidase complex is functional |
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Term
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Definition
| A molecule that binds to microbes and is recognized by receptors on phagocytes |
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Term
| Opsonin-mediated phagocytosis |
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Definition
| Phagocytosis resulting from the interaction of an opsonin wiht its receptor on a phagocyte |
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Term
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Definition
| refers to the presence of an opsonin on a microbe |
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Term
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Definition
| mechanism of cell destruction when a cell membrane is ruptured |
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Term
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Definition
| a molecule secreted by cytotoxic cells (NK and CD8+ T cells) |
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Term
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Definition
| A chimeric vesicle formed by the fusion of a phagosome with a lysosome |
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Term
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Definition
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Term
| Primitive Pattern Recognition Rectptors (PPRR) |
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Definition
| Receptors on phagocytes that recognize the sequences on a number of microbes or antigens |
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Term
| Reactive Nitrogen Intermediates (RNI) |
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Definition
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Term
Reactive Oxygen Intermediates
(ROI) |
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Definition
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Term
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Definition
| Molecule that is toxic; one of the reactive oxygen intermediates produced following the activation of NADPH OXIDASE |
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Term
Transforming Growth Factor Beta
(TGFB) |
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Definition
| Cytokine that inhibits iNOS |
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Term
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Definition
| Enzyme required to form HYPOCHLORITE from H2O2 and Cl ion |
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Term
| Natural killer cell activating receptor |
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Definition
| A recewptor present on NK cells; when bound to its ligand, results in ACTIVATION OF NK CELLS to KILL their target (expressing the ligand) |
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