Term
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Definition
INFLAMMATION
Activate Mphage to secrete IL-1,6,12,TNF
and
Chemokines IL-8, MCP-1
Chemokine denovo expess ICAM-1, VCAM-1, E-Selectin and enhance ICAM-2 adn secrete chemokines IL-8 and MCP-1 |
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Term
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Definition
Enhances NADPH oxidase activity
Activates iNOS with 2nd signal |
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Term
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Definition
Growth factor for T cells
Enhances NK cytotoxicity
Helps pCTL-->CTL
Inhibitory for Th17 |
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Term
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Definition
Hematopoesis:
need for BOTH myeloid and lymphoid progenitor cell development |
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Term
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Definition
Required to switch to IgE
Downregulates Th1
Downregulates iNOS (nt as gud as TFGB)
Shifts Th0 response --> Th2 |
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Term
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Definition
EOSINOPHILs !
Hematopoesis: differentiation of eosin.
Chemotactic for eosinophile
Activation of eosinophils |
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Term
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Definition
Stimulates secretion of CRP from hepatocytes (inflammation)
With TGFB leads to diff of Th0-->Th17 (pro-inflammatory!) |
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Term
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Definition
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Term
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Definition
Downregulation of IL-12 by dendritic cells and m-phages
Th1 cytokines
Downregulates iNOS (not as gud as TGFB) |
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Term
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Definition
| Activates NK cells to secrete IFNgamma |
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Term
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Definition
Activaes iNOS
Enhances activation of NADPH oxidase
Downregulates Th2
Critial for Th0-->Th1
With IL-2 promotes pCTL-->CTL
Enhances expression of MHC I and II |
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Term
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Definition
Triggers production of enzmes that interfere with replication of some viruses
Inhibition of T cell proliferation
Increase expression of Class I MHC
(2'5'oligoadenylate synthetase) |
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Term
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Definition
Downregulates iNOS
Critical for Th0 --> Tregs
WHEN PRESENT WITH IL-6
Differntiates Th0 --> Th17 |
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Term
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Definition
Induce expr. of PROinflammatory cytokines and chemokines frm wide range of cells (IL-6, IL-8, GM-CSF, G-CSF, metlloproteinases from mphages and others
Autoimmune disorders if Th17 cells not specific for self antigen
Chemotacti for Neutrophils |
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Term
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Definition
With TGFB diferentiates Th0 -->Th17
Growth factor (amplification) of Th17 cells |
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Term
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Definition
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Term
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Definition
Hematopoesis
Diferentiation of myeloid progenitor to GM progenitor |
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Term
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Definition
Hematopoesis
Differentiation of GM progenitor to granulocyte/neutrophil |
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Term
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Definition
Hematopoesis
GM progenitor --> monocyte |
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