Term
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Definition
Parenterally administered androgen
Highly bound to plasma proteins
Bioactivated to dihydrotestosterone by 5a-reductase |
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Term
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Definition
Promotes weight gain following extensive sgx, chronic infxn, trauma
Approved for alcoholic hepatitis, Turner's, and HIV weight loss
Not readily aromatized to estrogen |
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Term
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Definition
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Term
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Definition
Non-steroidal anti-androgen
Used in rx of prostatic cancer |
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Term
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Definition
Non-steroidal anti-androgen
Now replacing flutamide due to less hepatotoxic effects and once a day dosing |
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Term
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Definition
Inhibitor of 5a-reductase
Used to rx BPH and male pattern baldness
*Reduces incidence of prostate cancer, but cases more severe |
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Term
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Definition
Steroidal anti-andronergic
Weak partial agonist for androgen rec |
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Term
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Definition
released from the hypothalamus in a pulsatile fashion
acts on ant pituitary to stimulate FSH and LH release |
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Term
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Definition
Anti-estrogen
Fertility rx used to rx ovarian failure
Blocks estrogen-mediate inh of FSH/LH release
Can work too well! Many babies! |
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Term
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Definition
Purified FSH recovered from urine of menopausal women
Produces follicular stimulation |
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Term
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Definition
Recombinant FSH collected from urine of menopausal women
Produces follicular stimulation |
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Term
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Definition
Urofollitropin
Follitropin |
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Term
| Human chorionic gonadotropin |
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Definition
Collected from urine of pregnant women
Action similar to LH (induces ovulation)
Mimics LH surge following use of menotropin |
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Term
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Definition
Synthetic androgen used to inh FSH/LH in endometriosis in females
Atrophies ectopic endometrial tissue |
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Term
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Definition
GnRH analog
Rx of infertility due to hypothalamic amenorrhea
INTERMITTANT administration results in sustained FSH/LH release and OVULATION
FREQUENT administration desensitizes GnRH receptors and suppresses FSH/LH, cxing infertility
Used in PROSTATE CA to supress FSH/LH release |
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Term
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Definition
GnRH analog
Rx of infertility due to hypothalamic amenorrhea
INTERMITTANT administration results in sustained FSH/LH release and OVULATION
FREQUENT administration desensitizes GnRH receptors and suppresses FSH/LH, cxing infertility |
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Term
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Definition
GnRH analog
Rx of infertility due to hypothalamic amenorrhea
INTERMITTANT administration results an sustained FSH/LH release and OVULATION
FREQUENT administration desensitizes GnRH receptors and suppresses FSH/LH, cxing infertility |
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Term
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Definition
Pure GnRH Antagonist
Inh FSH/LH release w/o initial increase
Used in management of infertility to prevent premature LH surge |
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Term
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Definition
Pure GnRH Antagonist
Inh FSH/LH release w/o initial increase
Used in management of infertility to prevent premature LH surge |
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Term
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Definition
The major endogenous estrogen in humans
Weak oral potency |
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Term
| Pharmacokinetics of Steroidal Estrogens |
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Definition
Highly lipophilic, so well absorbed in GI
Extensively bound to plasma proteins
Hepatic metabolism |
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Term
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Definition
Premenopausal hypogonadism
Hormone replacement therapy
Rx breast, prostatic, and ENDOMETRIAL cancers
Oral contraceptives |
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Term
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Definition
steroidal estrogen
orally effective |
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Term
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Definition
steroidal estrogen
orally effective pro-drug, quickly demethylated to ethinyl estradiol |
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Term
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Definition
| Estradiol enters liver and binds to ER which dimerizes and binds to Estrogen Response Elements in promoter region of estrogen-activated genes |
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Term
| Metabolic effects of estrogens (7) |
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Definition
Inc bone density
inc HDL, dec LDL
vasodilation
fluid retention
inc chol secretion, dec bile secretion in GB
facilitates clot formation
Inc plasma hormone binding proteins |
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Term
| Adverse responses to estrogens (7) |
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Definition
1. Inc endometiral cancer w estrogen alone
2. Inc risk of clear-cell vaginal and cervical adenoCA after exposure in utero
3. Thromboemblic
4. Fetal abnormalities (NEVER GIVE IN PREGNANCY)
5. Inc GB dz
6. Migraines
7. N/V |
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Term
| Hormone replacement therapy effects (3) |
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Definition
Prevent osteoporosis
Rx vasomotor disturbances
Rx vaginal/vulvular atrophy |
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Term
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Definition
| Slow release oral estrogens |
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